Preparation method of decarbamyl cefuroxime

A technology of carbamoyl cephalosporins and nitroxides, applied in the field of medicines, can solve problems such as hidden dangers of safety and restricting the development of enterprises

Active Publication Date: 2021-09-10
GUANGDONG LIGUO PHARMACY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] The main feature of the furan ammonium salt synthesis process is to use a strong acid such as concentrated sulfuric acid to carry out the oxidation reaction in the presence of sodium nitrite, followed by oximation reaction with methoxyamine, and add ammonia to precipitate furan ammonium salt. Explosive ammonium sulfate and other salt slags pose significant safety hazards
[0009] The synthesis of SMIF-Cl(V) requires the

Method used

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  • Preparation method of decarbamyl cefuroxime
  • Preparation method of decarbamyl cefuroxime
  • Preparation method of decarbamyl cefuroxime

Examples

Experimental program
Comparison scheme
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Embodiment 1

[0029] Add water (40ml), palladium chloride (0.02mmol), sodium acetate (30mmol), NaI (0.5mmol), 2-bromofuran (10mmol), D-7-ACA (10mmol), nitrogen into 100ml autoclave successively After the replacement, stir the reaction under 1 atmosphere of carbon monoxide at 5-10°C. When HPLC shows that the D-7-ACA residue is less than 0.5%, exhaust the gas and dilute it with nitrogen, and then add dichloromethane to quench the reaction. Stir at 10°C for 30 minutes, stand still for 10 minutes to separate the liquid, collect the water phase, add dichloromethane, stir at 5-10°C for 30 minutes, stand still for 10 minutes, separate the liquid, collect the water phase, and combine the two water phases.

[0030] Under the condition of 5-10°C, add sodium bicarbonate (15mmol) and methoxyamine hydrochloride (11mmol) to the above water phase, and stir the reaction at 5-10°C, when HPLC shows that the residual product of the previous step is less than 0.5%. , add hydrochloric acid to adjust the pH of t...

Embodiment 2

[0032] Add polyethylene glycol, water mixture (40ml, volume ratio 1:2), palladium chloride (0.02mmol), sodium carbonate (20mmol), NaI (0.5mmol), 2-bromofuran ( 10mmol), D-7-ACA (10mmol), after nitrogen replacement, stir the reaction under 2 atmospheres of carbon monoxide at 5-10°C, when HPLC shows that the residual D-7-ACA is less than 0.5%, exhaust the gas and dilute with nitrogen After discharge, add dichloromethane to quench the reaction, stir at 5-10°C for 30 minutes, stand still for 10 minutes to separate the liquid, collect the water phase, add dichloromethane, stir at 5-10°C for 30 minutes, stand still for 10 minutes, separate the liquid, and collect water box.

[0033] Under the condition of 5-10°C, add sodium bicarbonate (15mmol) and methoxyamine hydrochloride (10mmol) to the above water phase, and stir the reaction at 5-10°C, when HPLC shows that the residual product of the previous step is less than 0.5%. , add hydrochloric acid to adjust the pH of the system to 1-...

Embodiment 3

[0035] Add water (40ml) successively in 100ml autoclave, palladium chloride (0.02mmol), sodium hydroxide (20mmol), NaI (0.5mmol), 2-bromofuran (10mmol), D-7-ACA (10mmol), After nitrogen replacement, stir the reaction under 2 atmospheres of carbon monoxide at 5-10°C. When HPLC shows that the D-7-ACA residue is less than 0.5%, exhaust the gas and dilute it with nitrogen, then add dichloromethane to quench the reaction. Stir at ~10°C for 30 minutes, stand still for 10 minutes to separate the liquid, collect the water phase, add dichloromethane, stir for 30 minutes at 5-10°C, stand still for 10 minutes, separate the liquid, and collect the water phase.

[0036] Under the condition of 5~10 DEG C, add sodium carbonate (15mmol), methoxylamine hydrochloride (10mmol) to above-mentioned water phase, stir reaction under 5~10 DEG C, when HPLC shows that the residual product of the previous step is less than 0.5%, Add hydrochloric acid to adjust the pH of the system to 1-5, and crystals ar...

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Abstract

The invention provides a preparation method of decarbamoyl cefuroxime. According to the method, 7-ACA or D-7-ACA is taken as a starting material and is subjected to one-step reaction with carbon monoxide and a compound I under the catalysis of metal palladium to obtain a decarbamoyl cefuroxime intermediate ketoamide, and the intermediate reacts with methoxyamine hydrochloride to obtain a product decarbamoyl cefuroxime, wherein the HPLC purity is 98.0% or above. The method has the characteristics of short route, high yield, high purity, less three wastes and suitability for industrial production.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to a preparation method of decarbamyl cefuroxime. Background technique [0002] Decarbamyl cefuroxime is an important intermediate of cefuroxime. Cefuroxime is a second-generation cephalosporin antibiotic developed by GSK. It was launched in the UK in 1978, in the United States in 1988, and in China in 1998. It is listed on the market and is suitable for upper and lower respiratory tract infections, urinary tract infections, skin and soft tissue infections caused by sensitive bacteria. It has the characteristics of broad antibacterial spectrum, clear curative effect, and less toxic and side effects. It belongs to the varieties included in the national basic drug list. [0003] Patents US3966717 and US3974153 reported that 7-ACA diphenylmethyl ester was used as a starting material to obtain carbamoyl cefuroxime diphenylmethyl ester through acylation reaction with SMIF-Cl. After rem...

Claims

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Application Information

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IPC IPC(8): C07D501/34C07D501/04
CPCC07D501/34C07D501/04
Inventor 王宝李亮邓德福陈剑明何菁华
Owner GUANGDONG LIGUO PHARMACY
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