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Multifunctional hydrogel and preparation method thereof

A hydrogel and multi-functional technology, which is applied in the fields of pharmaceutical formulation, medical science, and drug delivery, can solve the problems of destroying bacterial biofilm, weak tissue adhesion, and poor anti-infection ability, so as to promote wound healing and anti-infection. Infected wound healing, low cost effect

Pending Publication Date: 2022-03-04
GUANGZHOU MEDICAL UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although many hydrogel wound dressings have appeared clinically, such as: Kangweier, Tegaderm 3M , Aifuning and polyurethane gel, etc., but they are expensive, and they cannot effectively solve the key problems of destroying bacterial biofilm, improving wound microenvironment, poor anti-infection ability, weak tissue adhesion and poor healing when used in the treatment of infected wounds.

Method used

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  • Multifunctional hydrogel and preparation method thereof
  • Multifunctional hydrogel and preparation method thereof
  • Multifunctional hydrogel and preparation method thereof

Examples

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Effect test

Embodiment 1

[0039] Embodiment 1 multifunctional hydrogel and preparation method thereof

[0040] The multifunctional hydrogel of the present embodiment comprises 5 μL alcohol-cationic polymer aqueous solution (glycerol-polylysine polymer GEPL, 20wt%), 90 μL formylated biomedical polymer aqueous solution (F127 - p-Hydroxybenzaldehyde FCHO, 20 wt%) and 5 μL of DTPH (3,3'-dithiobis(propionyl hydrazide)) aqueous solution (10 wt%).

[0041] The preparation method of the multifunctional hydrogel of the present embodiment comprises the following steps:

[0042] (1), preparation of Pluronic F127-tosylate (F127-OTs)

[0043] Dissolve 6.2g of Pluronic F127 in 60mL of anhydrous chloroform, then add 0.42mL of triethylamine and 0.57g of p-toluenesulfonyl chloride successively, and react at room temperature for 24h. After the reaction was completed, the organic phase was washed with dilute hydrochloric acid and saturated sodium bicarbonate solution, respectively. After removing excess organic solven...

Embodiment 2

[0056] Embodiment 2 multifunctional hydrogel and preparation method thereof

[0057] The multifunctional hydrogel of the present embodiment comprises 30 μL alcohol-cationic polymer aqueous solution (polyethylene glycol-polylysine polymer PEPL, 10wt%), 120 μL formylated biomedical polymer aqueous solution ( F127-p-hydroxybenzaldehyde FCHO, 20wt%) and 20 μL of DTPH (3,3'-dithiobis(propionylhydrazide)) aqueous solution (5wt%) were prepared.

[0058] The preparation method of the multifunctional hydrogel of the present embodiment comprises the following steps:

[0059] (1), preparation of Pluronic F127-tosylate (F127-OTs)

[0060] With embodiment 1 step (1).

[0061] (2), preparation of F127-p-hydroxybenzaldehyde (FCHO)

[0062] With embodiment 1 step (2).

[0063] (3), preparation of polyethylene glycol-p-toluenesulfonate (PEG-Ots)

[0064] Dissolve 5g of polyethylene glycol (molecular weight: 2000) in 100mL of dichloromethane, then add 1.4mL of triethylamine and 1.9g of p-t...

Embodiment 3

[0070] Embodiment 3 multifunctional hydrogel and preparation method thereof

[0071] The multifunctional hydrogel of the present embodiment is composed of 10 μL alcohol-cationic polymer aqueous solution (pentaerythritol-polylysine polymer TEPL, 10 wt%), 80 μL formylated biomedical polymer aqueous solution (formylated Prepared by hyaluronic acid (HA-CHO, 5wt%) and 10 μL of DTPH (3,3'-dithiobis(propionylhydrazide)) aqueous solution (10wt%).

[0072] The preparation method of the multifunctional hydrogel of the present embodiment comprises the following steps:

[0073] (1), preparation of aldylated hyaluronic acid (HA-CHO)

[0074] Dissolve 1 g of hyaluronic acid (HA) in 100 mL of distilled water, add 210 mg of sodium periodate (NaIO 4 ) in the dark for 3 h at room temperature. After the reaction was completed, 500 μL of ethylene glycol was added to quench the reaction. Then, the reaction solution was dialyzed in distilled water for 3 days with a dialysis bag with a molecular...

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Abstract

The invention discloses a multifunctional hydrogel and a preparation method thereof, and the multifunctional hydrogel is prepared from an aqueous solution of an alcohol-cationic polymer, an aqueous solution of an aldehyde biomedical polymer and an aqueous solution of 3, 3 '-dithiobis (propionyl hydrazide). The multifunctional hydrogel disclosed by the invention can realize self-healing and rapid hemostasis, has redox responsiveness and relatively low cytotoxicity, has relatively strong antibacterial property on escherichia coli, staphylococcus aureus and methicillin-resistant staphylococcus aureus, can effectively resist a bacterial biofilm, and can be used for quickly stopping bleeding. The hemostatic material is simple in preparation method, low in cost, environment-friendly and low in toxicity, can effectively promote healing of mouse bacterial biofilm infectious skin wounds, is expected to become a novel multifunctional biological material capable of achieving hemostasis, infection resistance and wound healing promotion at the same time, and has a good application prospect in clinical treatment of chronic infectious skin wounds.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and more specifically, the invention relates to a multifunctional hydrogel and a preparation method thereof. Background technique [0002] Bacterial infection is the most common problem in skin wound healing and regeneration. The severe inflammatory response caused by infection not only significantly increases the number of diseases induced by wound infection, but also prolongs the normal inflammatory period due to the release of harmful enzymes, oxygen free radicals and inflammatory cells , eventually lead to tissue destruction, further deterioration of the wound, and it is difficult to heal. In addition, bacterial biofilms are easily formed on wounds infected by bacteria, and the bacteria in the biofilm wrap themselves in an extracellular polymeric (EPS) shielding matrix. The EPS matrix can act as a protective barrier, not only protecting bacteria from host innate immune cells, bu...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/008A61L26/0066A61L26/0061A61L26/0019A61L26/0023A61L2300/412A61L2400/04A61L2300/404C08L77/04C08L5/08C08L71/02C08L5/00
Inventor 周丽杨作婷郑华张秋禹张宝亮刘金保
Owner GUANGZHOU MEDICAL UNIV
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