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Fe/Mn double-metal-doped dual-mode light-emitting MOFs (Metal-Organic Frameworks) as well as preparation method and application thereof

A bimetallic, dual-mode technology, applied in the direction of luminescent materials, chemical instruments and methods, preparations for in vivo experiments, etc.

Active Publication Date: 2022-04-22
NORTHEAST FORESTRY UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The object of the present invention is to provide a kind of Fe / Mn bimetal doped dual-mode imaging MOFs, preparation method and application thereof, thereby solving the aforementioned problems existing in the prior art

Method used

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  • Fe/Mn double-metal-doped dual-mode light-emitting MOFs (Metal-Organic Frameworks) as well as preparation method and application thereof
  • Fe/Mn double-metal-doped dual-mode light-emitting MOFs (Metal-Organic Frameworks) as well as preparation method and application thereof
  • Fe/Mn double-metal-doped dual-mode light-emitting MOFs (Metal-Organic Frameworks) as well as preparation method and application thereof

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Embodiment 1

[0039] This embodiment provides a kind of Fe / Mn dual-metal doped dual-mode imaging MOFs, preparation method and application thereof, comprising the following steps:

[0040] (1) Preparation of core-shell structure nanocrystals: first step, first synthesize core nanocrystals, first add 270mg erbium chloride, 2.75mg thulium chloride, 6mL oleic acid and 15mL octadecene into a round bottom flask and mix together . Under vacuum conditions, magnetically stirred and heated to 100 °C for 30 min, then the mixture was placed under N 2 Heated to 150°C under protection for 30min, then cooled to room temperature. Afterwards, 10 mL of methanol solution containing 0.1 g of sodium hydroxide and 0.14 g of ammonium fluoride was slowly added into the flask, and stirred at room temperature for about 1 h. Subsequently, the mixed solution was slowly heated to 100° C. under vacuum state and kept for 30 min, and then the mixed solution was heated to 300° C. and kept for 1 h under nitrogen atmospher...

Embodiment 2

[0045] The present embodiment provides a kind of Fe / Mn dual-metal doped dual-mode imaging MOFs, preparation method and application thereof, including the following steps: (1) Preparation of core-shell structure nanocrystals: the first step is to synthesize core nanocrystals Crystal, 270.5mg of erbium chloride, 2.8mg of thulium chloride, 7mL of oleic acid and 16mL of octadecene were added to the round bottom flask and mixed together. Under vacuum conditions, magnetically stirred and heated to 110 °C for 40 min, then the mixture was placed under N 2 Heated to 155°C under protection for 40min, then cooled to room temperature. Afterwards, 11 mL of methanol solution containing 0.11 g of sodium hydroxide and 0.15 g of ammonium fluoride was slowly added into the flask, and stirred at room temperature for about 1 h. Subsequently, the mixed solution was slowly heated to 110° C. under vacuum state and kept for 35 min, and then the mixed solution was heated to 305° C. and kept for 1.1 h...

Embodiment 3

[0049] The present embodiment provides a kind of Fe / Mn dual-metal doped dual-mode imaging MOFs, preparation method and application thereof, including the following steps: (1) Preparation of core-shell structure nanocrystals: the first step is to synthesize core nanocrystals To crystallize, first add 271mg of erbium chloride, 2.85mg of thulium chloride, 8mL of oleic acid and 17mL of octadecene into a round bottom flask and mix them together. Under vacuum conditions, magnetically stirred and heated to 120 °C for 50 min, then the mixture was placed under N 2 Heated to 160°C under protection for 50min, then cooled to room temperature. Afterwards, 12 mL of methanol solution containing 0.12 g of sodium hydroxide and 0.16 g of ammonium fluoride was slowly added into the flask, and stirred at room temperature for about 1 h. Subsequently, the mixed solution was slowly heated to 120° C. under vacuum state and kept for 40 min, and then the mixed solution was heated to 310° C. and kept f...

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Abstract

The invention provides Fe / Mn double-metal-doped dual-mode imaging MOFs, a preparation method and application thereof.The Fe / Mn double-metal-doped dual-mode imaging MOFs are prepared by the steps that rare earth nanocrystals serve as cores, the cores are coated with a layer of rare earth nanocrystal shells through an epitaxial growth method, then the surfaces of the rare earth nanocrystals are subjected to PVP modification, double-metal-doped ZIF-8 grows on the surfaces of the rare earth nanocrystals, and the Fe / Mn double-metal-doped dual-mode imaging MOFs are obtained. The nanocrystal with the structure has obviously enhanced up-down conversion luminescence performance, and can realize in-vivo up-conversion fluorescence imaging and near-infrared two-region imaging. After laser irradiation, a semiconductor can be excited to generate active oxygen and oxygen, Fe < 2 + > and Mn < 2 + > doped in the outermost shell layer can generate a Fenton-like effect with hydrogen peroxide in a tumor in a free state to realize chemical kinetic treatment, and glutathione in the tumor can also be consumed. Therefore, the nano composite material not only can realize in-vivo dual-mode optical imaging, but also has a photodynamic and chemical kinetics synergistic treatment effect on tumor cells, and has better application in the aspects of cancer diagnosis and treatment.

Description

technical field [0001] The invention relates to the technical field of preparation of luminescent MOFs, in particular to a dual-mode luminescent MOF doped with Fe / Mn double metals, a preparation method and an application thereof. Background technique [0002] Lanthanide-doped nanoparticles (LDNPs) are known for their outstanding optical properties and have been widely used in biological applications, especially bioanalysis and medical imaging. In recent years, the near-infrared (NIR) wavelength range has attracted considerable attention due to its fast feedback, high spatial resolution, and deep tissue penetration ability. LDNPs also have great potential in realizing multimodal imaging based on optical imaging. In terms of optical imaging, due to the significant suppression of photon scattering and autofluorescence, the current research focus has shifted from the traditional short-wavelength window to the second near-infrared window (NIR-II, 1000-1700nm). Compared with flu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G83/00C09K11/06A61K47/34A61K49/00
CPCC08G83/008C09K11/06A61K47/34A61K49/0054C09K2211/14
Inventor 徐加廷李春生付玉杰叶金王军吕武斌王强张志永刘志国
Owner NORTHEAST FORESTRY UNIVERSITY
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