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32 results about "Informed choice" patented technology

Use of FKBPL gene to identify a cause of infertility

Fertility problems affect (1 in 10) couples in Western society, making it one of the most common serious health issues. Despite this, little is known about the causes of infertility, and thus patient counseling and treatment are suboptimal. With infertility being such a common problem, identification of any cause would impact on a large number of patients, allowing better counseling, clearer diagnoses and the possibility of making more informed choices (e.g. adoption vs. IVF treatment). The present invention provides methods to identify a cause of infertility in a subject based on the genotype of the subject, in particular, by evaluating the status of the gene encoding FK506 binding protein-like (FKBPL). In particular, the present invention relates to use of the status of the gene encoding FK506 binding protein-like for identification of a cause of an infertile phenotype in a subject. Also provided, are methods method for identifying an infertile phenotype in a subject, and identifying a cause of an infertile phenotype in a subject. This diagnostic tool finds wide clinical utility in the identification of a cause of infertility, resultantly impacting on a large number of patients. Further aspects of the present invention relate to the targeting of FKBPL in order to temporarily and reversibly induce infertility in a subject. Such aspects of the present invention find utility in the development of a male contraceptive pill. Moreover, due to the high degree of homology between the human and mouse FKBPL gene, FKBPL can be targeted in order to induce infertility in mice (or other species) as a form of pest control or animal husbandry.
Owner:UNIVERSITY OF ULSTER

Application of Chinese medicine balloonflower as in-vitro spermaticide and method for preparing the medicament

The invention discloses an application of the traditional Chinese medicine platycodon grandiflorum as an in vitro spermicidal medicine and a method for preparing the medicine. The Chinese medicine platycodon grandiflorum is used as a raw material for in vitro spermicidal medicine, and its extract is prepared into an emulsion or a suppository for vaginal contraceptive medicine. The preparation method of the medicine is to grind the bellflower raw material of traditional Chinese medicine, soak it in 0.9% normal saline, the ratio of the bellflower raw material to the normal saline is 100 grams: 900-1200 milliliters, place it in a metal bath at 100°C and heat it, take it out After filtering to remove slag, the extract of Platycodon grandiflora is obtained, and the extract of Platycodon grandiflorum is made into emulsion or suppository, which is used for killing sperm in vitro. Experiments of the present invention show that the extract of Platycodon grandiflorum has no stimulation and burning phenomenon on the vaginal mucosa, and has no destructive effect on the vaginal flora, is absorbed by the human body through the vaginal mucosa without any toxic and side effects on human organs, can be used for a long time, and has the advantages of convenient use Advantages, provide a non-toxic, cheap, easy to use, reliable contraceptive effect informed choice method for family planning.
Owner:SHANDONG PROVINCIAL FAMILY PLANNING INST OF SCI & TECH
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