The invention relates to an automatic infusion device, a control system and a control method. The control device comprises a drug placement mechanism, a first drug grabbing mechanism, a drug cover opening mechanism, a disinfection mechanism, a second drug grabbing mechanism, an extraction mechanism, a third drug grabbing mechanism, and a fourth drug grabbing mechanism. The control method comprisesthe steps that: 1, a nurse places drugs in the drug placement mechanism according to doctor's advice; 2, an infusion preparation drug sequence is input; 3, a drug identification mechanism identifiesrequired drugs in the drug placement mechanism according to the infusion preparation drug sequence; 4, the drug grabbing mechanisms grab the required drugs; 5, the drug cover opening mechanism opens drug packages according to types of the drugs; 6, the extraction mechanism extracts the drugs; 7, whether the preparation of an infusion drug is completed is judged, if so, a step 8 is entered, otherwise, the step 3 is entered; 8, and the drug grabbing mechanisms transfer the prepared drug to an infusion control mechanism, and an input end of the infusion control mechanism is communicated with an infusion bag or an infusion bottom to carry out infusion.