The present invention relates to novel compounds and formulations. In addition, the present invention relates to novel compounds and formulations useful in pneumococcal and pneumococcal conjugate vaccines. More specifically, the present invention relates to compositions comprising a pneumococcal conjugate and one or more compounds of Formula I, Ia, II, IIa, III, IIIa, IV, or IVa, or a pharmaceutically acceptable salt thereof, which are prepared as stable nanoemulsions (referred to herein as "SNE
adjuvant compositions" or "SNE").