The invention discloses an audio-video multiplexing device. The multiplexed video ES (Elementary Stream) and audio PES (Packetized Elementary Stream) both are obtained from an external memory, the video ES is generated by a video encoder in an encoding manner, and an audio PES packet is formed by an audio encoder in a manner of encoding and packaging; a CPU (Central Processing Unit) part packages the program specific information (PSI) and the program clock reference (PCR) into a TS (Transmission Stream) packet according to the syntax rules of the transmission stream (TS) in the standard, and simultaneously generates a video PES head and the configuration information needed for other multiplexer hardware accelerators; and the multiplexer hardware accelerator part selects to multiplex the TS packet and a padding packet into the transmission stream with constant output rate according to a multiplexing strategy, wherein the TS packet is formed by packaging of the PSI, the PCR and the audio-video PES. The invention provides an audio-video multiplexing device, which can process high-definition video in real time, and is high in flexibility, simple in hardware structure, small in delay, constant in multiplexing rate and small in PCR jitter.