94results about How to "Improve the circumference" patented technology

A device for removing obstructions from vessels or small openings in the body, comprising a rotatable ablator tip which is guided to the obstruction in a reduced diameter configuration, expanded and rotated to remove the obstruction, and contracted to remove the device from the body. The variably expandable abrasive tip coil in one embodiment of the invention is actuated by a piston means disposed within the coil. A pair of collars is attached to the ends of the coil, and the piston effects relative longitudinal axial movement of the collars and, hence, the respective ends of the coil tip. When the ends of the coil tip are so moved with respect to one another, expansion and contraction of the diameter of the coil tip results. In another embodiment of the invention, the expansion tip coil is actuated by an expandable and contractible bellows means disposed within the coil, instead of the piston means. In another embodiment of the invention, the expansion and contraction of the coil tip are effected by longitudinal axial movement of an internal coil attached to one end of the coil tip, within an outer coil attached to the other end of the coil tip. In another embodiment of the invention, expansion and contraction of the coil tip are effected by an inflatable balloon disposed within the coil tip. The balloon expansion means enlarges preferably at the central portion of the coil to make a bulge. +RR The questions raised in reexamination request No. 90 / 003,360, filed Mar. 15, 1994, and 90 / 003,723 filed Feb. 14, 1995, have been considered and the results thereof are reflected in this reissue patent which constitutes the reexamination certificate required by 35 U.S.C. 307 as provided in 37 CFR 1.570(e).

A urological balloon catheter has electrodes in a region of its shaft proximally adjoining the balloon, which electrodes lie uncovered on the outer surface of the shaft and can be connected to a high-frequency generator via lines which run through the shaft in the proximal direction.

A multi-sectional utility pole includes at least two sections of straight pipe, which are joined and connected by a slip joint connection. The slip joint preferably consists of two mating conical sections, with one attached to each section of the pole. The slip joint is compressed with the aid of rings, which are attached to the pipe, and a key and slot. The two conical sections are fastened together with bolts that pass through the female conical section and thread into the male conical section of the slip joint. The pole is easily assembled on the ground and the pole sections are fungible with other sections of the same diameter. The sections are also inexpensively manufactured. The conical sections can be swaged from the ends of the pipe, or can be fabricated separately and welded on to the ends of the pipe.

An apparatus and method for identifying the flexor retinaculum of the carpal tunnel, injecting an effective amount of an agent into at least a portion of flexor retinaculum or tissue adjacent thereto, wherein the agent is configured to weaken the flexor retinaculum. The system may further include means for increasing the tensile stress in the flexor retinaculum post-injection using hand exercises, thereby weakening its structural integrity and decreasing the pressure within the carpal tunnel that impairs median nerve function.

A screen panel retainer system is useable to retain a plurality of screen panels to a separatory machine. Retainer bars are attached to the screen stringer rails of the separatory machine by an expanding of spaced plugs that are received in holes in the stringer rails. The retainer bars each include a plurality of ears that are receivable in pockets that are situated on the inner faces of screen panel edge strips. A plurality of dams, each of which is securable to the screen edge strip ends of two adjacent screen panels, serve to further secure the screen panels in place. Screen panel removal is easily accomplished and the system is adaptable to various machine configurations.

The invention relates to an ankle stabilizing apparatus for minimizing inversion and eversion of the foot, and more specifically, to a body member having at least one cuff member positioned against a cuff portion of the body member, wherein the cuff member defines at least one opening for receiving at least one stabilizing strap such that the cuff and stabilizing strap dynamically apply a variable force against the body member and ankle. The invention promotes variable compression against the ankle upon application and during wear. The invention also resists distal migration of the apparatus during wear.

Methods and formulations for treating metabolic disorders in humans using epimetabolic shifters, multidimensional intracellular molecules or environmental influencers are described.

An adjustable collar having a vertical fabric strip hole through which a fabric strip passes unimpeded. The fabric strip is secured to a free end of an elastic strip, which is secured to a shirt band at a first end of the elastic strip. A button is secured to a free end of the fabric strip and the button passes through a horizontal buttonhole defined in an end of an outer portion of a neckband of the shirt. The fabric strip is retracted and hidden when the collar is open. The button is larger than a diameter of the fabric strip hole to prevent the fabric strip from retracting completely through the vertical fabric strip hole.

The all-in-one prophy angle for cleaning teeth contains a self dispensing solid core prophy paste which allows the operator to perform an entire prophylaxis of the teeth with the efficiency of not having to remove the handpiece from the mouth, further, cross contamination from splatter is minimal to none. The prophy cup and solid core paste are in a changeable cartridge form allowing the prophy handpiece to be reusable. The cartridge in another preferred embodiment is integral with a disposable prophy angle.

A screen panel retainer system is useable to retain a plurality of screen panels to a separatory machine. Retainer bars are attached to the screen stringer rails of the separatory machine by an expanding of spaced plugs that are received in holes in the stringer rails. The retainer bars each include a plurality of ears that are receivable in pockets that are situated on the inner faces of screen panel edge strips. A plurality of dams, each of which is securable to the screen edge strip ends of two adjacent screen panels, serve to further secure the screen panels in place. Screen panel removal is easily accomplished and the system is adaptable to various machine configurations.

The present invention relates to piperazinone-substituted tetrahydro-carboline derivatives of formula (I):having the substituents as described herein which are melanin-concentrating hormone (MCH-1) receptor antagonists. The present invention also relates to pharmaceutical compositions including these compounds, and methods of preparation and use thereof.

The present invention provides methods and compositions for modulating certain metabolic processes and for treating a variety of disorders associated with metabolic syndrome, including insulin related disorders, ischemia, oxidative stress, atherosclerosis, hypertension, obesity, abnormal lipid metabolism, and stroke by administering an effective dose of a chloroquine compound. The invention also provides methods and compositions relating to administering an effective dose of a chloroquine compound in combination with at least a second pharmaceutically active ingredient or compound including an antihyperglycemic diabetes treatment, an antihypertensive agent, an antithrombotic agent, and / or an inhibitor of cholesterol synthesis or absorption.

Novel MCH-1 receptor antagonists are disclosed. These compounds are used in the treatment of various disorders, including obesity, anxiety, depression, non-alcoholic fatty liver disease, and psychiatric disorders. Methods of making these compounds are also described in the present invention.

An ankle stabilizing apparatus for minimizing inversion and eversion of the foot, and more specifically, a body member having at least one cuff member positioned against a cuff portion of the body member, wherein the cuff member defines at least one opening for receiving at least one stabilizing strap such that the cuff and stabilizing strap dynamically apply a variable force against the body member and ankle. The apparatus promotes variable compression against the ankle upon application and during wear. The apparatus also resists distal migration during wear.

The present invention relates to piperazinone-substituted tetrahydrocarboline derivatives of formula (I):having the substituents as described herein which are melanin-concentrating hormone (MCH-1) receptor antagonists. The present invention also relates to pharmaceutical compositions including these compounds, and methods of preparation and use thereof.

An injection or grouting body for the transfer of mechanical stresses in structures in above-ground or below-ground construction, and for insertion into a borehole, in slits or similar openings, has a centrally-arranged filling tube and at least one fabric stocking surrounding the filling tube. The filling tube is embodied as a fabric stocking and one or a plurality of reinforcing wires and / or rods, and / or pipes and / or ridged sheet metal strips are arranged on site so as to be adaptable, axis-parallel between the fabric stockings. An outer closed fabric stocking is arranged along the axis of the injection body about its inner filling tube (Fabric tube) that is open at its lower end. The reinforcing wires or rods are arranged on the outside of the inner fabric stocking and are attached to the fabric of the outer stocking in such a way that it can be ensured that, following filling or grouting, the reinforcement will remain in position.

Flat objects are distributed by a device which includes a transport section that is used to transport a stream of flat objects to be distributed, and a plurality of sequentially arranged paddle wheels or delivery fans, each of which has at least one component that is configured to receive an object from the transport section. Each paddle wheel delivers its object to a distribution point. The paddle wheels can be rotated, with respect to each other, to provide a phase shift which permits each of a number of objects, which corresponds to the number of paddle wheels in the sequence, to be received by a compartment of a different one of the number of paddle wheels.

Novel MCH-1 receptor antagonists are disclosed. These compounds are used in the treatment of various disorders, including obesity, anxiety, depression, non-alcoholic fatty liver disease, and psychiatric disorders. Methods of making these compounds are also described in the present invention.

The present invention is directed to a method of treating a metabolic disorder or key elements of a metabolic disorder such method comprising the use of an agent(s) that increases central dopaminergic activity plus a first-phase insulin secretagouge.

The present invention is directed to a method of treating a metabolic disorder or key elements of a metabolic disorder such method comprising the use of an agent(s) that increases central dopaminergic activity plus a first-phase insulin secretagouge.

Novel MCH-1 receptor antagonists are disclosed. These compounds are used in the treatment of various disorders, including obesity, anxiety, depression, non-alcoholic fatty liver disease, and psychiatric disorders. Methods of making these compounds are also described in the present invention.

A 3D hand-shaped glove includes a performance-enhancing layer laminated to a fabric glove shell. A flat, solid laminate preform can be prepared with printed graphics, fabric layers, oriented films, dense and / or concentrated fillers, and other features. The 3D hand-shaped glove shell is placed on a 3D laminating form, and the preform is laminated thereto while preserving the 3D shape. In embodiments, the laminating form includes opposing flat surfaces, and a platen or roller press is used. In other embodiments, a bladder or vacuum bag press is used to laminate the preform to a curved or otherwise shaped surface of the laminating form. In embodiments, edge peel resistance is enhanced by extending the perimeter of a low modulus upper layer beyond underlying layers and bonding it directly to the glove shell. Recovery of the glove shell after deformation by the laminating form can provide a warping deformation of the laminate preform.

A system, apparatus and methods for facilitating personal safety monitoring via an apparatus with multiple sensors are disclosed. The sensors may include a number of biometric sensors including a body temperature sensor, a pulse rate sensor and a blood oxygen sensor and / or any other sensors. The apparatus may be configured to generate various alerts in response to signals generated by the sensors. For example, the apparatus may generate a variety of biometric stress alerts corresponding to different biometric stress signatures associated with the biometric sensors. The alerts generated by the apparatus may be transmitted to a server or a client device associated with the apparatus for further processing, which may include generating a notification for presentation on the client device in response to an alert being received from the apparatus.

The invention relates to a magnet valve, having a valve insert and a tappet guided movably in the valve insert via a tappet guide, which tappet is braced on a valve body via a restoring spring resting a contact face of the tappet, and the restoring spring is guided radially from inside on one end by a spring guide of the tappet, the spring guide adjoining the contact face. According to the invention, centering means are present, which are disposed on the tappet in such a way that the restoring spring is centered and radially guided from inside over a substantial portion of its length.

An adjustable suit is provided which includes an optional torso section having front and back portions and a torso circumference, a waist section having a front portion and a back portion and a waist section circumference, and a leg section including a pair of legs. Each of the legs has a leg opening therein, and each of the leg openings has a leg opening circumference. The suit includes at least one adjustable member which extends generally along at least one of the optional torso, waist, and leg sections. The at least one adjustable member is adapted to increase or decrease at least one of the optional torso, waist, and leg opening circumferences to reduce the time and effort needed to don and take off the suit. The adjustable features of the suit also permit the wearer to tighten one or more sections of the suit to accommodate the different physiques of wearers while providing a snug fit and support during athletic or work activities.

A method of mounting a light emitting diode (LED) module (100) to a heat sink (102), the method comprising the steps of placing the LED module (100) in a hole (120) in the heat sink (102); and expanding a portion of the LED module (100) such that the LED module (100) is secured to the heat sink (102). The method provides a cost efficient way of securing an LED module to a heat sink where the mount has a high reliability over time.