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Bioactivity surface modification method of biological medical degradable magnesium alloy

A bioactive, biomedical technology, applied in the fields of medical science, prosthesis, coating, etc., can solve the problems of insufficient degradation speed, large surface roughness, difficult process control, etc., and achieve the improvement of degradation speed and biological activity. , the effect of improving biological activity and improving the success rate of implantation

Active Publication Date: 2013-03-13
INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The invention provides a method for bioactive surface modification of biomedical degradable magnesium alloys, which can control the degradation rate of magnesium alloys and obtain bioactive surface coatings to solve the problem of bioactive coatings prepared directly on magnesium alloy substrates. The layer has the disadvantages of poor bonding force, low density, large surface roughness, insufficient control of the degradation rate of the magnesium alloy matrix, and difficult process control.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Firstly, a phosphate-based conversion coating is prepared in a conversion liquid from pure magnesium with a purity of 99.99%, the temperature is 20-60°C, and the soaking time is 3-10 minutes; the composition of the conversion liquid is as follows:

[0019] Sodium phosphate: 100g / L;

[0020] Potassium permanganate: 10-50g / L;

[0021] the rest is water;

[0022] Phosphoric acid adjusts pH=3.0-4.0;

[0023] In this example, a phosphate-based conversion coating was prepared, with magnesium phosphate as the main component, and a thickness of 90 μm.

[0024] Then, wash and dry with deionized water, and use the sol-gel method to prepare a hydroxyapatite coating on the outer layer of the phosphate-based conversion film. The specific preparation process is: according to the molar ratio of Ca / P=1.67, respectively prepare Ca(NO 3 ) 2 4H 2 O and P 2 o 5 ethanol solution. Then Ca(NO 3 ) 2 4H 2 O alcohol solution was added dropwise to P 2 o 5 The alcohol solution was st...

Embodiment 2

[0027] AZ31 (Mg-Al series) magnesium alloy in Ce(NO 3 ) 3 The rare earth conversion film is prepared in the conversion liquid as the main component; the composition of the conversion aqueous solution is: Ce(NO 3 ) 3 : 11g / L, KMnO 4 : 4g / L, the pH value is 2, the temperature is 35°C, and the time is 20min.

[0028] The composition of the rare earth conversion film prepared in this example is CeO 2 and MgO with a thickness of 120 μm.

[0029] Then, vacuum plasma spraying process (Ar, H 2 It is plasma gas, the vacuum chamber pressure is 150mbar, the powder feeding rate is 20g / min, the current: 650A, the voltage is 60V), and the hydroxyapatite powder with a particle size range of 10-100μm is used to prepare hydroxyapatite on the outer surface. The thickness of the resulting hydroxyapatite coating was 130 μm.

[0030] After coating, the AZ31 magnesium alloy was immersed in simulated body fluid at 37°C for 3 days, and a new Ca-P layer was observed on the surface under an elec...

Embodiment 3

[0032] Anodic oxidation is used on the surface of AE42 (Mg-Al series) magnesium alloy (the electrolyte composition is, NaOH: 50-60g / l, Na 2 SiO 3 : 30-40g / l, H 3 BO 3 : 20-25g / l, Na2 CO 3 : 30-35g / l, the rest is water; voltage: 90-100V, time 20-35min) to prepare magnesium alloy surface oxide film, its thickness is 10 μ m; then, adopt bionic method (bionic solution composition is: Na 2 HPO 4 12H2O: 20-60g / l, Ca(NO 3 ) 2 : 30-50g / l, the rest is water; temperature: 25-90°C, time: 2-48h) Prepare a β-TCP coating on the outer surface with a thickness of 100μm.

[0033] The cytotoxicity of the samples was detected by the MTT method. The results showed that the toxicity of the coated magnesium alloy was level 1, which met the requirements for the use of biomedical materials, while the toxicity of untreated magnesium alloys was level 3, which could not meet the requirements of biomedical materials on cells. Toxicity requirements, indicating that magnesium alloy surface coating c...

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Abstract

The invention relates to the technical field of biomaterial, is particularly applicable to the field of surface modification of a biological medical material, in particular to a biological activity surface modification method for a biological medical degradable magnesium alloy. The method is to prepare a surface coating on magnesium or a magnesium alloy, and comprises the following steps that: an intermediate chemical conversion film is prepared on the surface of the magnesium or the magnesium alloy; and then a ceramic layer with biological activity is prepared on the outer layer. The surface coating not only can control the degradation speed of a matrix of the magnesium or the magnesium alloy, but also has surface activity. The surface coating comprises the intermediate chemical conversion film and the outer biological activity ceramic layer, wherein the intermediate chemical conversion film not only can control the degradation speed of the matrix of the magnesium matrix, but also can improve the preparation performance and bonding force with the matrix of the outer biological activity ceramic layer; and the outer biological activity ceramic layer improves the biological activity of an implanting body, and enhances bonding strength of the implanting body and an organism so as to improve the success ratio of implantation. The invention aims to solve the problems of fast degradation and low surface biological activity of a degradable biological medical magnesium alloy.

Description

technical field [0001] The invention relates to the technical field of biomaterials, and is particularly suitable for the field of surface modification of biomedical materials; specifically, it relates to a method for bioactive surface modification of biomedical degradable magnesium alloys. Background technique [0002] In recent years, magnesium alloys have attracted great attention due to their good biomechanical properties, biocompatibility and in vivo degradability, and are expected to become a new generation of degradable implant materials. Magnesium alloy has high specific strength and specific stiffness, and its strength can exceed 200Mpa; the density of pure magnesium is about 1.74g / cm3, which is equivalent to the compact bone density of human bone (1.75g / cm3); Young's modulus is about 45GPa , which is closer to the elastic modulus of human bone (about 20GPa), which can significantly reduce the stress shielding effect. [0003] Magnesium alloys are very active in th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/42A61L27/04A61L27/32
Inventor 谭丽丽耿芳杨柯张炳春
Owner INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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