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Surface-modified iron oxide magnetic nano-particle and surface modification method thereof

A magnetic nanoparticle and surface modification technology, which is applied in the field of iron oxide magnetic nanoparticle and its surface modification, to achieve the effects of easy promotion and industrial production, simple process and good dispersibility

Inactive Publication Date: 2009-12-02
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Although at present there are literatures reporting multiple methods of preparing surface-functionalized iron oxide magnetic nanoparticles by chemical modification (such as the Chinese patent applications with publication numbers CN 1990528 and CN 101269844), they are far from meeting the needs. Therefore, the development It is still an important issue to develop a variety of surface modification methods for iron oxide magnetic nanoparticles and to obtain iron oxide magnetic nanoparticles with different surface functionalization.

Method used

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  • Surface-modified iron oxide magnetic nano-particle and surface modification method thereof
  • Surface-modified iron oxide magnetic nano-particle and surface modification method thereof
  • Surface-modified iron oxide magnetic nano-particle and surface modification method thereof

Examples

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Effect test

Embodiment 1

[0028] This embodiment prepares iron oxide magnetic nanoparticles with oleic acid, and the process steps are as follows:

[0029] (1) Add 1000mg of iron triacetylacetonate to 50ml of octyl ether containing 5% (volume percent) oleic acid under nitrogen protection, heat to 300°C and reflux for 0.5 hours, wait for the reaction mixture to cool to room temperature, and use a syringe Extract 2% (volume percentage) of the reaction mixture from the system for preservation.

[0030] (2) Add trimethylamine oxynitride to the reaction mixture, the amount of trimethylamine oxynitride is 10% of the volume of the reaction mixture, and after being heated to 120°C for 1 hour under the protection of nitrogen, the temperature is raised to 10°C / min. Reflux at 300°C for 2 hours, then lower the temperature of the system to 100°C, inject the reaction mixture taken out in step (1) into the system, heat to 300°C and reflux for 2 hours, cool to room temperature, add 50ml of ethanol and ultrasonically s...

Embodiment 2

[0032] In this embodiment, the iron oxide magnetic nanoparticles with oleic acid prepared in Example 1 are surface-modified, and the process steps are as follows:

[0033] (1) Surface aldylation of iron oxide magnetic nanoparticles with oleic acid

[0034] 50 mg of iron oxide magnetic nanoparticles with oleic acid prepared in Example 1, 10 ml of cyclohexane, 0.05 mg of osmium tetroxide (prepared into an aqueous solution with a mass concentration of 1% with deionized water), and 10 mg of sodium perchlorate.

[0035] Disperse the iron oxide magnetic nanoparticles with oleic acid in cyclohexane at room temperature and normal pressure, then add osmium tetroxide aqueous solution and sonicate for 10 minutes, then add sodium perchlorate and sonicate for 0.5 hours, followed by magnetic stirring After 3 hours, the magnetic separation was carried out after the magnetic stirring was completed, and the magnetic iron oxide magnetic nanoparticles on the surface obtained by the magnetic sepa...

Embodiment 3

[0040] In this embodiment, the iron oxide magnetic nanoparticles with oleic acid prepared in Example 1 are surface-modified, and the process steps are as follows:

[0041] (1) Surface aldylation of iron oxide magnetic nanoparticles with oleic acid

[0042] 200 mg of iron oxide magnetic nanoparticles with oleic acid prepared in Example 1, 40 ml of hexane, 2 mg of chromium trioxide (prepared as an aqueous solution with a mass concentration of 10% with deionized water), and 50 mg of potassium periodate.

[0043] Disperse the iron oxide magnetic nanoparticles with oleic acid in hexane at room temperature and normal pressure, then add chromium trioxide aqueous solution and sonicate for 50 minutes, then add potassium periodate and sonicate for 2 hours, then magnetically stir for 5 minutes hour, magnetic separation is carried out after the magnetic stirring ends, and the iron oxide magnetic nanoparticles on the surface of the magnetic separation obtained are washed 4 times with deion...

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Abstract

The invention provides a surface-modified iron oxide magnetic nano-particle. The surface of the surface-modified iron oxide magnetic nano-particle is bonded to amino and hydroxyl, or amino and carboxyl, or amino, hydroxyl and carboxyl functional groups. A surface modification method for iron oxide magnetic nano-particles comprises the following: (1) a process step of aldehyde-grouping the surfaces of the iron oxide magnetic nano-particles, which is to disperse the iron oxide magnetic nano-particles with oleic acids in organic solvent, add oxidant and supply ultrasound for 10 to 50 minutes, add inorganic salt and supply ultrasound for 0.5 to 3 hours, magnetically stir for at least 3 hours, magnetically separate surface aldehyde-grouped iron oxide magnetic nano-particles and wash the nano-particles with water; and (2) a process step of performing surface multifunctional modification on the iron oxide magnetic nano-particles, which is to add the surface aldehyde-grouped iron oxide magnetic nano-particles and multifunctional-group organic molecules at least containing amino groups to sodium dihydrogen phosphate / potassium hydroxide buffer solution and supplying ultrasound for 10 to 30 minutes, magnetically stir for at least 1 hour, magnetically separate obtained nano-particles, wash the obtained nano-particles with water and dry the obtained nano-particles in vacuum.

Description

technical field [0001] The invention belongs to the field of surface modification of iron oxide magnetic nanoparticles, and relates to iron oxide magnetic nanoparticles with multiple functional groups on the surface and a surface modification method thereof. Background technique [0002] With the rapid development of materials science and engineering, nanotechnology, biotechnology and modern medicine, iron oxide magnetic nanoparticles are widely used in the field of biomedicine, especially in high-resolution nuclear magnetic resonance imaging (MRI), anticancer drug magnetically controlled targeted release system, The research and application of rapid cell separation and purification, early diagnosis of cancer, etc. are attracting more and more attention. However, whether it is used in vivo or in vitro, the more prominent common problems involve the following aspects: First, how to reduce the self-aggregation of iron oxide magnetic nanoparticles and the adsorption of plasma p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01F1/26B22F1/02
Inventor 顾忠伟于长江何斌吴尧聂宇李莉王刚
Owner SICHUAN UNIV
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