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Preparation method of magnetic fluorescence dual functional thermo-sensitive nano particle

A nanoparticle and fluorescent nanotechnology, which is applied in the field of preparing magnetic and fluorescent bifunctional temperature-sensitive nanoparticles, can solve the problems of poor polymer designability, uncontrollable molecular weight and distribution, and unstable use, so as to reduce the quenching effect, Non-toxic toxicity, avoiding the effect of agglomeration

Inactive Publication Date: 2010-07-14
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

As we all know, the main disadvantages of conventional free radical polymerization are poor designability, uncontrollable molecular weight and distribution of the polymers obtained; while living polymerization overcomes these shortcomings, it makes it possible to accurately synthesize polymers with various topological structures.
[0005] However, there has not been any report at home and abroad that directly connects compounds with fluorescent groups to the surface of magnetic nanoparticles by living free radical polymerization; Unstable during use, therefore, a stable method for preparing magnetic and fluorescent bifunctional nanoparticles is needed

Method used

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  • Preparation method of magnetic fluorescence dual functional thermo-sensitive nano particle
  • Preparation method of magnetic fluorescence dual functional thermo-sensitive nano particle
  • Preparation method of magnetic fluorescence dual functional thermo-sensitive nano particle

Examples

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Embodiment 1

[0044] Example 1: Immobilization of RAFT reagents on the surface of magnetic nanoparticles

[0045] Synthesis of Magnetic Fe by Co-precipitation 3 o 4 nanoparticles, and then use Hydrolysis of Tetraethyl Orthosilicate to Magnetic Fe 3 o 4 Nanoparticles are encapsulated to form Fe 3 o 4 @SiO 2 core-shell structure.

[0046] Take 1.0g Fe 3 o 4 @SiO 2 Add 0.5 mL of 4-chloromethylphenyltrimethoxysilane to 20 mL of toluene that has been dehydrated and dried at 95 ° C, flow argon for 20 min, reflux for 24 h, and collect by centrifugation. With a large amount of toluene and acetone for multiple ultrasonic dispersion-centrifugal washing, the chloromethylated product Fe 3 o 4 @SiO 2 -Cl was vacuum-dried at room temperature for use.

[0047] In DMSO (20mL) solution with 0.13g KOH dissolved, add 0.39g carbazole, after stirring for 1h, slowly add 0.2mL C 2 S, after the resulting red solution was stirred at room temperature for 12 hours, the chloromethylated product Fe of t...

Embodiment 2

[0048] Example 2: Using N-isopropylacrylamide (NIPAM) as a monomer to synthesize temperature-sensitive nanoparticles with dual functions of magnetism and fluorescence.

[0049] Take monomer (NIPAM) 0.5g, Fe 3 o 4 @SiO 2 - BCBD 100mg (~0.014mmol RAFT), sacrificial RAFT reagent (BCBD) 2.7mg, AIBN 0.21mg, isopropanol 2.5mL in a 5ml ampule bottle, and replace the oxygen in the system with Ar gas, seal the ampule bottle and place Carry out the reaction (12-70h) according to the predetermined time in an oil bath at a constant temperature (60°C);

[0050] After the reaction, take out the sealed tube, cool it with cold water immediately, open the sealed tube, dissolve and dilute with tetrahydrofuran, then disperse-centrifuge 4 times, pour the supernatant into petroleum ether to precipitate, and the obtained polymer is characterized by GPC; and magnetic bifunctional temperature-sensitive nanoparticles (Fe 3 o 4 @SiO 2 -PNIPAM).

[0051] From figure 1 It can be seen that after g...

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Abstract

The invention discloses a preparation method of a magnetic fluorescence dual functional thermo-sensitive nano particle. The preparation method comprises the following steps: (1) preparing a nano particle core by a routine method, then packing the magnetic nano particle with a layer of silicon dioxide, performing cholromethylation on the silicon dioxide by utilizing a chloromethyl silane coupling agent, and leading benzyl chloride wrapped on the surface of the nano particle to react with carbon disulfide in the dimethylsulfoxide solution of potassium hydroxide so as to obtain a magnetic fluorescence nano particle the surface of which is modified with an RAFT reagent; and (2) utilizing the magnetic fluorescence nano particle obtained in step (1), a thermo-sensitive monomer, a sacrificed RAFT reagent and an initiating agent to form a polymerizing system and dissolving in solvent, carrying out reversible addition-fragmentation chain transfer (RAFT) living radical polymerization, and then performing separating to obtain the magnetic fluorescence dual functional thermo-sensitive nano particle with a nuclear shell structure. RAFT polymerization is directly carried out on the surface of the magnetic silicon oxide nano particle, thus facilitating the magnetic fluorescence dual functional nuclear shell structure to keep the stability of the structure and performance in the actual application process.

Description

technical field [0001] The present invention relates to a preparation method of magnetic fluorescent bifunctional core-shell structure nanoparticles, in particular to a method of using magnetic nano-silica hybrid particles modified with fluorescent groups as macromolecular RAFT reagents to break chains through reversible addition The transfer (Reversible addition-fragmentation chain transfer, RAFT) living radical polymerization method is a method for the controllable preparation of magnetic fluorescent bifunctional temperature-sensitive nanoparticles. Background technique [0002] Nanoparticles with magnetic and fluorescent dual functions have broad application prospects in biomedical fields such as magnetic resonance imaging (MRI) and biomarkers. According to the structure of different magnetic / fluorescent nanomaterials, their preparation strategies can be divided into the following eight types: (1) the magnetic core is encapsulated by a silica shell containing fluorescent ...

Claims

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Application Information

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IPC IPC(8): C08F292/00C08F220/54C09K11/06
Inventor 程振平李强朱秀林张丽芬张正彪
Owner SUZHOU UNIV
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