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Method for preparing intra-operative hemostatic material by cross emulsification of plant starch

A plant starch and hemostatic material technology, applied in the field of hemostatic materials, can solve the problems of unsatisfactory hemostasis effect, unsatisfactory active bleeding effect, rebleeding, etc., so as to promote tissue wound healing, not easily change physical and chemical properties, and promote tissue healing effect

Active Publication Date: 2013-07-17
杜宝堂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the preparation process, epichlorohydrin was used as a cross-linking agent, which is a colorless oily liquid, toxic and narcotic, and potentially harmful to the human body; from the perspective of hemostatic effect, the water absorption rate is low and the water absorption speed is low. slow, and the hemostatic effect is not ideal, especially for active bleeding; the gel formed after absorbing water has poor viscosity and cannot effectively block damaged tissues and blood vessels. In active bleeding, hemostatic powder is difficult Attached to the bleeding site, it is easy to be washed away by the blood flow. If the auxiliary material is pressed on the hemostatic powder, the auxiliary material is easily adhered by the blood clot, and it is easy to cause re-bleeding when the auxiliary material is uncovered. Therefore, the effect on active bleeding is not ideal. and expensive
[0008] CN1947800A discloses a hemostatic microparticle and its preparation method. The hemostatic microparticle is made of potato starch, emulsified with liquid paraffin and span80, then cross-linked with epichlorohydrin, extracted with ethyl acetate and ethanol, and heated and dried. The modified starch prepared by this method is only dried by ordinary methods, and the obtained microspheres have different particle sizes, and their water absorption and adhesion properties are low, and they have no microporous structure. Modified starch, no clinical value
[0009] CN101559235A discloses a compound microporous starch powder hemostatic agent and a preparation method thereof. The method uses potato starch and sweet potato starch as raw materials, first gelatinizes, then punctures holes with enzymes, cross-links with sodium trimetaphosphate, and then uses Drying by freeze-drying method, the obtained compound microporous modified starch, because the process does not adopt the emulsified microsphere preparation step, the obtained modified starch is mostly ellipsoidal, with low mechanical strength, easy to break due to water absorption and swelling, and poor adhesion

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The method for preparing intraoperative hemostatic material through cross-emulsification by using vegetable starch comprises the following steps:

[0037] (1) Gelatinization: Dissolve raw potato starch in distilled water to prepare a wet starch solution with a weight percentage of 12%, and then add it to the extrusion extruder, and the starch will be rubbed and extruded by the screw shaft to generate heat and then gelatinized , at 120°C, it is extruded through a small hole with a diameter of 3mm on the extruder under high pressure, and the material is expanded and dried after entering the atmosphere, and then crushed and screened to obtain gelatinized starch;

[0038] (2) Enzymolysis: the gelatinized starch that has been gelatinized and pretreated as described in step (1) is prepared into an emulsion with a weight percentage of 25%, and then an enzyme solution prepared with a buffer is added to it, Among them, the mass ratio of enzyme to starch is 0.05:1, the temperatur...

Embodiment 2

[0045] The method for preparing intraoperative hemostatic material through cross-emulsification by using vegetable starch comprises the following steps:

[0046] (1) Gelatinization: Dissolve raw sweet potato starch in distilled water to prepare a wet starch solution with a weight percentage of 20%, and then add it to the extrusion extruder, and the starch will be rubbed and extruded by the screw shaft to generate heat and then gelatinized , at 160°C, it is extruded through a small hole with a diameter of 8mm on the extruder under high pressure, and the material is expanded and dried after entering the atmosphere, and then crushed and screened to obtain gelatinized starch;

[0047] (2) Enzymolysis: the gelatinized starch that has been gelatinized and pretreated as described in step (1) is prepared into an emulsion with a weight percentage of 40%, and then an enzyme solution prepared with a buffer is added to it, Among them, the mass ratio of enzyme to starch is 0.1:1, the tempe...

Embodiment 3

[0054] The method for preparing intraoperative hemostatic material through cross-emulsification by using vegetable starch comprises the following steps:

[0055] (1) Gelatinization: Dissolve cassava raw starch in distilled water to prepare a wet starch solution with a weight percentage of 16%, and then add it to the extruder, and the starch will be rubbed and extruded by the screw shaft to generate heat and then gelatinized , at 140°C, it is extruded through a small hole with a diameter of 7 mm on the extruder under high pressure, and the material is expanded and dried after entering the atmosphere, and then crushed and screened to obtain gelatinized starch;

[0056] (2) Enzymolysis: the gelatinized starch that has been gelatinized and pretreated as described in step (1) is prepared into an emulsion with a weight percentage of 30%, and then an enzyme solution prepared with a buffer is added to it, Among them, the mass ratio of enzyme to starch is 0.06:1, the temperature is con...

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PUM

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Abstract

The invention discloses a method for preparing an intra-operative hemostatic material by cross emulsification of plant starch. The method comprises the following steps of: taking plant starch as a raw material; gelatinizing; carrying out enzymolysis; emulsifying and cross-linking; carrying out solvent extraction; washing; spray-drying; sieving; sterilizing; and packaging to obtain the hemostatic material. The hemostatic material prepared by adopting the method disclosed by the invention has excellent biological barrier properties and tissue compatibility, can directly act on a hemorrhagic wound surface, and is especially convenient for organs and tissues with complex shapes. The selected material is plant starch which has the advantages of no toxicity, no irritation, rich sources, low price, simple and feasible production processes, high water absorption speed, short hemostatic time, good using effect and wide clinical application prospect.

Description

technical field [0001] The invention relates to a method for preparing a microporous polysaccharide hemostatic material, in particular to a method for preparing a microporous polysaccharide hemostatic material through cross-emulsification using plant starch, and belongs to the technical field of hemostatic materials. Background technique [0002] Both surgical operations and trauma will form blood wounds, and a large amount of blood will be lost during the period. Good hemostasis technology is the key to ensure the success of the operation and the healing of the trauma. According to statistics, more than 10% of the wounded who died in the first aid of wounds in battlefields and peacetimes died due to excessive blood loss. The use of biocompatible absorbable hemostatic materials to act on bloody wounds is a common method of hemostasis at present, and there is an urgent need in medical aspects such as surgical hemostasis, trauma, and first aid hemostasis. To provide a safe and...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28C08J3/24
Inventor 杜宝堂
Owner 杜宝堂