Method for preparing sinomenine hydrochloride by using non-organic solvent

Abstract

The invention provides a preparation method of sinomenine hydrochloride. The method comprises the steps of: A) extraction: wetting caulis sinomenii coarse powder by using hydrochloric acid (HCl), installing a percolator, adding HCl for impregnation and percolation to obtain percolate; B) eluting treated cation exchange resin or 152 resin on the percolate by using ammonia water-ethanol solution or HCl with concentration being 3-10 percent, desalting, condensing and drying to obtain sinomenine hydrochloride crude products; and C) taking the sinomenine hydrochloride crude products, heating the crude products in ethanol or purified water for back flowing, condensing filtrate, cooling, crystallizing, filtering and using ethanol to wash a filter cake to obtain the sinomenine hydrochloride. Since the method adopts an absorbing process through the cation exchange resin or large-pore absorbing resin to replace the traditional extraction process through high-toxicity benzene and chloroform, the extraction rate is high, the method is simpler and convenient to operate, the harm and the pollution caused by high quantity of high-toxicity organic solvent to operator health and the environment can be avoided, the treatment process of the organic solvent is reduced, the environmental protection is further facilitated, the investment in environmental protection facilities of a factory is reduced and the environmental-friendly production is facilitated. The sinomenine hydrochloride prepared by adopting the method through extraction and separation can be used as a raw material for pharmaceutical preparations, the purity is higher, solvent residue does not exists and the potential harm to human bodies is reduced.

Description

technical field [0001] The invention relates to a preparation method of sinomenine hydrochloride, in particular to a method for extracting the active ingredient sinomenine hydrochloride in Caulis chinensis by non-organic solvent. Background technique [0002] Qingfengteng is a traditional Chinese medicine commonly used in traditional Chinese medicine. It is the dry cane of Fangjiaceae plants Qingteng and Ivy twig. Meridian, urination effect, used to treat rheumatic arthralgia, joint swelling, numb itching, anti-arrhythmia and antihypertensive effects. [0003] The main components in C. chinensis are alkaloids. The components that have been found so far are Sinomenine, Igoginomenine, SinoAcutine, Acutumidine, and Acutumine. Sinaetine and Diginomenine, Ethylsinomenine, Sinactine, Tetrahydroepiperberine, Bat Pueroline, Bat Ge Ning, Tetrahydropalmatine et al. [0004] Sinomenine (Sinomenine) is an alkaloid monomer extracted from Teng chinensis. It is the main active ingredien...

AI Technical Summary

Problems solved by technology

(Chen Yukun's "Chinese Medicine Extraction Technology", 1992), the existing methods all use very toxic benzene or chloroform as the extraction solvent, and benzene is a first-class toxic solvent with a high carcinogenesis rate, which has been banned in the pharmaceutical industry, and in The recovery and treatment of solvents requires a very complicated process to meet environmental protection requirements, and chloroform is a secondary toxic reagent, so benzene and chloroform solvents should be avoided as much as possible in the extraction of traditional Chinese medicine

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