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Ginger and garlic enteric-coated tablet and preparation method thereof

A ginger garlic sausage and tablet-dissolving technology is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, plant raw materials, etc., and can solve the problems of unstable storage of soft capsules and capsules, low content of garlic powder tablets, and easy deterioration. and other problems, to achieve the effect of high active ingredients, overcoming low content of active ingredients and strong antibacterial effect.

Active Publication Date: 2013-03-13
江西中天医药生物有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The original ginger and garlic products have some disadvantages. Both soft capsules and capsules have disadvantages such as unstable storage and easy deterioration; garlic powder tablets have the disadvantages of low content of limited ingredients and strong garlic flavor.

Method used

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  • Ginger and garlic enteric-coated tablet and preparation method thereof
  • Ginger and garlic enteric-coated tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Among them, the garlic essential oil is peeled, cleaned, and crushed to a particle size of 6-7mm, loaded into the material cylinder, placed in the extraction kettle to start the extraction device, according to the set extraction and separation conditions: extraction temperature 35 ° C, pressure 25Mpa, static soaking The extraction time was 60min, the cycle time was 160min, and the separation temperature was 45°C. The test was carried out; the extract garlic essential oil was collected from the separation kettle.

[0020] Among them, the ginger essential oil is freshly cut ginger added with appropriate amount of water, crushed for 10 minutes, adjusted to pH 6, added with 2.2% ginger weight cellulase, and enzymolyzed at 46°C for 2 hours, then suction filtered, and the filtrate was used Petroleum ether extraction, vacuum distillation, recovery of solvent, collection of oil with strong aroma, drying with anhydrous sodium sulfate, that is.

[0021] The preparation method of ...

Embodiment 2

[0026] The preparation method of ginger and garlic enteric-coated tablets is as follows: mix the garlic essential oil, ginger essential oil and 95% ethanol evenly in the formula, add β-cyclodextrin for inclusion, pass the inclusion compound through a 18-mesh sieve, and then refill the inclusion compound powder. Add povidone, low-substituted hydroxypropyl cellulose, crospovidone, carboxymethyl starch sodium, microcrystalline cellulose, hydroxypropyl methyl cellulose, magnesium stearate, mix well, press into tablets, The tablets are then enteric-coated with enteric-coated Opadry.

[0027] Among them: the inclusion method of ginger and garlic volatile oil is colloidal milling method: weigh β-cyclodextrin: water weight ratio 1:12, put water into the colloidal grinding hopper, stir continuously, slowly add β-cyclodextrin, Grind for 20 minutes, slowly add volatile oil according to the volume ratio of volatile oil: β-cyclodextrin inclusion aqueous solution 1:10, grind for 2 hours, re...

Embodiment 3

[0032] The preparation method of ginger garlic enteric-coated tablets is as follows: mix the garlic essential oil, ginger essential oil and 95% ethanol evenly in the formula, add β-cyclodextrin for inclusion, pass the inclusion compound through a 20-mesh sieve, and refill the inclusion compound powder. Add povidone, low-substituted hydroxypropyl cellulose, crospovidone, carboxymethyl starch sodium, microcrystalline cellulose, hydroxypropyl methyl cellulose, magnesium stearate, mix well, press into tablets, The tablets are then enteric-coated with enteric-coated Opadry.

[0033] Among them: the inclusion method of ginger and garlic volatile oil is ultrasonic method: mix according to β-cyclodextrin: water weight ratio of 1:20, shake well, heat and dissolve in water bath, let cool to room temperature, according to the inclusion of volatile oil: β-cyclodextrin The volume ratio of the aqueous solution is 1:20, slowly add volatile oil, ultrasonic treatment for 120 minutes, refrigera...

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Abstract

The invention provides a ginger and garlic enteric-coated tablet and a preparation method thereof. The ginger and garlic enteric-coated tablet is prepared from ginger and garlic essence as raw materials by a beta-cyclodextrin inclusion process, has broad-spectrum antibacterial action, and also the functions of reducing blood fat and blood sugar, resisting atherosclerosis, resisting tumor, improving the organism immunity, and the like, and is high in technical content, high in inclusion rate, accurate in product drug release position, and high in bioavailability, so that the medicine is high in effective ingredient content, and strong in antibacterial action, thus overcoming the shortcomings that the previous product is low in effective ingredient content, has unpleasant odor, is inconvenient to carry and the like, and ensuring the quality of the product.

Description

technical field [0001] The invention relates to a ginger garlic enteric-coated tablet and a preparation method thereof, belonging to the field of pharmaceutical preparations. Background technique [0002] In today's world, with the continuous improvement of people's material living standards and the aging population structure, various diseases caused by overnutrition and malnutrition have always plagued us and seriously threatened human health. Such as high blood pressure, high blood fat, high cholesterol and so on. The whole world is very concerned about the cause of health. Therefore, the research and development of nutritional and health food that can regulate human body functions, prevent diseases and promote health has attracted more and more attention and attention from the scientific and industrial circles of various countries. In recent years, people study garlic and ginger and find that they are not only rich in nutrition, but also have great medicinal value; there...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61K9/36A61K47/40A61P31/04
Inventor 高国文
Owner 江西中天医药生物有限公司
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