Ferroferric oxide nano-composite particle and preparation method and applications thereof

A ferric tetroxide and nanocomposite technology, applied in the directions of iron oxide/iron hydroxide, nanotechnology, ferrous oxide, etc., can solve the problems of difficult to use in the microenvironment, calcium loss, liver and kidney damage, etc.

Inactive Publication Date: 2013-08-14
HEFEI INSTITUTES OF PHYSICAL SCIENCE - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are deficiencies in both the magnetic microspheres and their preparation methods. First, although the final product has good fluorescent and magnetic properties, as well as biological stability and water solubility, and can be further functionally modified , to be applicable to the field of biomedicine, but it cannot be used to detect a variety of heavy metal ions that widely exist in related fields such as drinking water, environment, food and medicine; and excessive copper content in the human body will cause gastrointestinal disorders, and It can cause damage to liver, kidney and other organs. If the zinc content exceeds the standard, symptoms such as nausea, vomiting, acute abdominal pain, diarrhea and fever will occur, which is the so-called zinc poisoning. Cadmium is a carcinogen that can cause prostate cancer. Cadmium poisoning It will cause calcium loss, osteomalacia, etc. Excessive mercury content will cause respiratory failure, liver and kidney damage and other serious consequences
Second, the particle size of the final product is too large to be conveniently used in microenvironments, such as the intracellular environment
Finally, the preparation method not only cannot produce the target products for detecting four heavy metal ions of copper, zinc, cadmium and mercury, but also needs to coat the surface of ferric oxide nanoparticles with silicon dioxide to make the surface aminated. In addition to making the process complicated, it also increases the cost of production

Method used

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  • Ferroferric oxide nano-composite particle and preparation method and applications thereof
  • Ferroferric oxide nano-composite particle and preparation method and applications thereof
  • Ferroferric oxide nano-composite particle and preparation method and applications thereof

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Effect test

Embodiment 1

[0028] The concrete steps of preparation are:

[0029] Step 1, first according to the weight ratio of ferric chloride hexahydrate, sodium acetate, 1,6-hexanediamine and ethylene glycol is the ratio of 0.8:2.2:8:32, ferric chloride hexahydrate, sodium acetate and 1,6-hexanediamine were added to ethylene glycol and stirred until a clear solution was formed. Then put the transparent solution in a closed state, react at 180°C for 8 hours, and then perform solid-liquid separation, washing and drying; wherein, the solid-liquid separation treatment is magnetic separation, and the washing treatment is sequentially using ethanol and deionized Washed with water once, and dried at 20° C. to obtain ferric oxide nanoparticles.

[0030] Step 2, first according to the weight ratio of 1,4-dihydroxyanthraquinone, chloroacetyl chloride and N,N-dimethylformamide is 0.22:0.6:38 ratio, 1,4-dihydroxyanthraquinone and chlorine Acetyl chloride was added to N,N-dimethylformamide and kept at 0°C for ...

Embodiment 2

[0033] The concrete steps of preparation are:

[0034] Step 1, first according to the weight ratio of ferric trichloride hexahydrate, sodium acetate, 1,6-hexanediamine and ethylene glycol is the ratio of 0.9:2.1:9:31, ferric trichloride hexahydrate, sodium acetate and 1,6-hexanediamine were added to ethylene glycol and stirred until a clear solution was formed. Then put the transparent solution in an airtight state, and after reacting at 190°C for 7.5 hours, it is subjected to solid-liquid separation, washing and drying; wherein, the solid-liquid separation treatment is magnetic separation, and the washing treatment is sequentially using ethanol and dehydration. The ion water was washed twice, and the drying treatment was to dry at 28° C. to obtain ferric oxide nanoparticles.

[0035] Step 2, first according to the weight ratio of 1,4-dihydroxyanthraquinone, chloroacetyl chloride and N,N-dimethylformamide is 0.23:0.5:39 ratio, 1,4-dihydroxyanthraquinone and chlorine Acetyl c...

Embodiment 3

[0038] The concrete steps of preparation are:

[0039] Step 1, first according to the weight ratio of ferric chloride hexahydrate, sodium acetate, 1,6-hexanediamine and ethylene glycol is the ratio of 1:2:10:30, ferric chloride hexahydrate, sodium acetate and 1,6-hexanediamine were added to ethylene glycol and stirred until a clear solution was formed. Then put the transparent solution in a closed state, react at 200°C for 7 hours, and then perform solid-liquid separation, washing and drying; wherein, the solid-liquid separation treatment is magnetic separation, and the washing treatment is sequentially using ethanol and deionized Washed with water for 3 times, and dried at 35° C. to obtain ferric oxide nanoparticles.

[0040]Step 2, first according to the weight ratio of 1,4-dihydroxyanthraquinone, chloroacetyl chloride and N,N-dimethylformamide is 0.24:0.4:40 ratio, 1,4-dihydroxyanthraquinone and chlorine Acetyl chloride was added to N,N-dimethylformamide and kept at 0°C f...

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Abstract

The invention discloses a ferroferric oxide nano-composite particle and a preparation method and applications thereof. The composite particle is a ferroferric oxide nano-composite particle with the particle size of 10-30nm, and 1,4-dihydroxy anthraquinone and fluorenylmethoxycarbonyl are modified on the surface of the ferroferric oxide nano-composite particle. The preparation method comprises the steps of: firstly, carrying out a hydrothermal method on ferric trichloride hexahydrate, sodium acetate, 1,6-hexanediamine and ethanediol to obtain the ferroferric oxide nano-composite particle, then producing 1,4-dihydroxy anthraquinone, chloroacetyl chloride, and N,N-dimethylformamide into dyes, then adding the ferroferric oxide nano-composite particle, sodium carbonate and the dyes into acetonitrile to carry out a reflux reaction, carrying out solid-liquid separation, washing and drying on the obtained reaction liquor to obtain an intermediate product, then dispersing the intermediate product into the N,N-dimethylformamide, adding dispersion liquid into the fluorenylmethoxycarbonyl, stirring for 2 hours, and carrying out solid-liquid separation, washing and drying to obtain a target product. The ferroferric oxide nano-composite particle can be used for fast detecting four heavy metal ions, namely copper, zinc, cadmium and mercury in an aqueous solution.

Description

technical field [0001] The invention relates to a composite particle, its preparation method and application, in particular to a ferric oxide nanocomposite particle, its preparation method and application. Background technique [0002] Based on the superparamagnetism of ferroferric oxide nanoparticles which are different from conventional magnetic materials, it is easy to separate and recycle them by using an external magnetic field. , protein separation, drug loading and release, early diagnosis and treatment of cancer and magnetic storage and other fields have great application value. Recently, people have made some attempts and efforts in order to explore and expand the application range of ferric oxide nanoparticles, such as a "multifunctional core" disclosed in the Chinese invention patent application document CN 102120168A published on July 13, 2011. Fluorescence-encoded magnetic microspheres with shell structure and its preparation method". The magnetic microspheres...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01G49/08B82Y40/00G01N21/64
Inventor 王美玲孟国文黄青鲁逸林谷瑶
Owner HEFEI INSTITUTES OF PHYSICAL SCIENCE - CHINESE ACAD OF SCI
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