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Semen-coicis extract with function of reducing blood uric acid and method for preparing same

A coix seed extract and coix seed technology, applied in the field of application and preparation of traditional Chinese medicine extracts in the treatment of patients with hyperuricemia and gouty diseases, can solve the problem of lowering blood uric acid with less side effects, and achieve good blood uric acid reduction , The effect of simple preparation process

Inactive Publication Date: 2013-10-30
ZHEJIANG UNIV CITY COLLEGE +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no drug that has a good effect of lowering blood uric acid, has few side effects, and is suitable for long-term medication.

Method used

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  • Semen-coicis extract with function of reducing blood uric acid and method for preparing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Capsule preparation

[0019] Add 6 times the amount of ethyl acetate to coix seed and ultrasonically extract twice, 1.5 hours each time, concentrate the extract, mix the extract and microcrystalline cellulose at a mass ratio of 1:2, dry, crush, and add 1% sucrose ester , 0.5% magnesium stearate, and filled into hard capsules.

Embodiment 2

[0021] tablet preparation

[0022] Coix seed is added with 10 times the amount of 80% ethanol and heated under reflux to extract twice, 1 hour each time, the extract is concentrated, the coix seed extract and microcrystalline cellulose are mixed according to the mass of 1:2, dried, crushed, added to disintegrate Agent and other auxiliary materials such as micro-powder silica gel are mixed evenly, granulated and pressed into tablets.

Embodiment 3

[0024] Study on the effect of coix seed extract on lowering blood uric acid

[0025] 1. Experimental animals and materials

[0026] 1.1 Animals

[0027] Sixty adult male quails were purchased from a vegetable market in Hangzhou. The animals were kept in a clean animal breeding room and had free access to food and water. Light and dark alternated for 12 hours. The room temperature is 24-26°C and the relative humidity is 70%.

[0028] 1.2 Materials and Instruments

[0029] Uric acid (LOT: STB7849V, Sigma-Aldrich Co.Ltd.); olive oil; coix seed; allopurinol (lot number: 090102, Chongqing Qingyang Pharmaceutical Co., Ltd.); Tween-80 (lot number: 20090901, Wenzhou Qingming Chemical Co., Ltd.); ethanol, sucrose ester, microcrystalline cellulose (Huadong Pharmaceutical Co., Ltd. Chemical Agent Branch); sodium carboxymethylcellulose (batch number: 010923, Shanghai Celluloid Factory) rotary evaporator; water bath; round bottom flask ; Alcohol meter.

[0030] 1.2 Experimental meth...

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Abstract

The invention relates to a novel pharmacological action of an extract of the semen coicis which is a Chinese herbal medicine, and particularly relates to an application of the extract of the semen coicis to the reduction of the blood uric acid of a patient with hyperuricemia or gout. The extract of the semen coicis has the function of significantly reducing the level of the blood uric acid of a quail with the uric-acid induced hyperuricemia. A process for preparing an oral preparation from the semen coicis comprises the following steps: heating the semen coicis, extracting the semen coicis repeatedly for 1-3 times by taking the effective components including the ethyl acetate and the aqueous ethanol as extracting solvents, removing the dregs of a decoction, removing the solvents at normal pressure or reduced pressure, and adding auxiliary materials. The method for preparing the traditional Chinese medicine from the semen coicis is simple, the extract of the semen coicis can be prepared into various preparations, and the traditional Chinese medicine prepared from the extract of the semen coicis is effective in reducing the blood uric acid.

Description

Technical field [0001] The invention relates to a coix seed extract with the effect of lowering blood uric acid, in particular to the application and preparation method of the traditional Chinese medicine extract in the treatment of patients with hyperuricemia and gouty diseases. Background technique [0002] Coix seed is the dry mature seed kernel of Coix lacryma-jobi L.var.ma-yuen (Roman.) Stapf, a grass plant. Coix seed is a cereal product with both medicine and food, which has been included in the Chinese Pharmacopoeia. Yang Shuang and others published the article "Review of Coix Seed Chemical Constituents and Their Activities" in "Chinese Medicinal Materials", Volume 34, No. 8, 2011, summarizing the research results on the chemical components and pharmacological activities of Coix Seed in recent years: Kernel contains protein, amino acid, mineral element, fatty acid and lipid compound, sterol, polysaccharide, triterpene, alkaloid and other active ingredients, which hav...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8994A61P19/06A61K131/00
Inventor 傅旭春刘二刚白海波
Owner ZHEJIANG UNIV CITY COLLEGE
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