Oral probiotic composition

A composition and technology of probiotics, applied in the field of biomedicine, to achieve the effect of inhibiting Helicobacter pylori

Inactive Publication Date: 2015-03-11
NANJING CANCHEN MICROBIAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Oral probiotic products in the international market mainly use this strain, and its safety and effectiveness have been fully verified

Method used

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  • Oral probiotic composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] 1.1 Preparation of Streptococcus salivarius K12 bacterial powder

[0043] Streptococcus salivarius K12 solid culture uses MRS medium: 2g casein peptone, 2g beef extract, 1g yeast extract, 1g glucose, 1g sodium acetate, 0.4g diamine citrate, 0.2g Tween-80, 0.4g dipotassium hydrogen phosphate , magnesium sulfate 0.04g, manganese sulfate 0.001g, calcium carbonate 4g, agar 3g, distilled water 200ml, pH7.2, the culture condition is 37℃ in 5% CO 2 cultured in an incubator.

[0044] Liquid culture of Streptococcus salivarius K12 strain, according to lactose 7g, sucrose 3.5g, glucose 3.5g, tryptone 14g, soybean peptone 7g, yeast extract 7g, dipotassium hydrogen phosphate / potassium dihydrogen phosphate 0.02mol / L, magnesium sulfate 200mg / L, manganese sulfate 100mg / L, calcium chloride 60mg / L, VitB1 10mg / L, distilled water 1L to prepare a liquid medium, adjust the pH to 7.2, and contain 5% CO at 37°C 2 cultured in an incubator. The bacterial strain is cultivated in the liquid fo...

Embodiment 2

[0049] 2.1 Preparation of Streptococcus salivarius K12 bacterial powder

[0050] Streptococcus salivarius solid culture was prepared by using 4g of beef extract, 2g of peptone, 4g of starch, 3g of agar, and 200mL of distilled water. The pH was 7.2, and the culture conditions were 37°C and 5% CO. 2 cultured in an incubator.

[0051] 2.2 Preparation of composition buccal tablets

[0052] According to the mass percentage final concentration in buccal tablets, add traditional Chinese medicine extracts, tea polyphenols 0.1~0.5%, glycyrrhizic acid 0.1~1.0%, menthol 0.1~1.0%, eugenol 0.01~0.10%; add xylitol 1 %~9%, 0.1%~1% magnesium stearate. Compressed into oral probiotic lozenges.

[0053] Liquid culture of Streptococcus salivarius K12 strain, according to lactose 7g, sucrose 3.5g, glucose 3.5g, tryptone 14g, soybean peptone 7g, yeast extract 7g, dipotassium hydrogen phosphate / potassium dihydrogen phosphate 0.02mol / L, magnesium sulfate 200mg / L, manganese sulfate 100mg / L, calciu...

Embodiment 3

[0055] Preparation of Composition Tablets

[0056] prescription:

[0057]

[0058] 3.1 Granulation

[0059] 3.1.1 Dry mixing: Add the prescribed amount of Streptococcus salivarius K12 bacteria powder, plant extracts, xylitol, and microcrystalline cellulose into the wet granulator, at a stirring speed of 150r / min and a granulating speed of 1500r / min Mix for 5 min.

[0060] 3.1.2 Granulation: add an appropriate amount of purified water at a mixing speed of 200r / min and a granulation speed of 1500r / min, and the granulation time is 3 to 4 minutes. Observe the particle formation and stop the machine in due course.

[0061] 3.1.3 Wet whole grain

[0062] Use 8mm×8mm aperture screen for wet sizing.

[0063] 3.2 Drying

[0064] Measure the moisture after the material temperature at the drying end is 50°C, if the moisture content is less than 2.0%, the drying is over, otherwise continue to dry.

[0065] 3.3 Whole grain - unloading

[0066] The sieve diameter of the granulato...

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Abstract

The invention relates to an oral probiotic composition, which contains Streptococcus salivarius K12, and one or more of the Chinese herb extract effective ingredients eugenol, tea polyphenol, glycyrrhizic acid, menthol, radix scrophulariae total glycoside, hericium erinaceus polysaccharide, Pachymaran, a dark plum water extract, and pueraria isoflavone. The composition can adjust oral flora balance, clean the oral cavity and improve oral air, and also has the efficacy of diminishing inflammation and relieving sore swollen throat.

Description

technical field [0001] The invention belongs to the field of biomedicine, in particular to a composition containing oral probiotic Streptococcus salivarius K12 and active ingredients of traditional Chinese medicine extracts. Background technique [0002] Type the technical field description paragraph here. Streptococcus salivarius K12 ( Streptococcus salivarius K12) is Streptococcus salivarius ( Streptococcus salivarius Andrews and Horder), the serial number is ATCC Number: BAA1024. [0003] Probiotics are active microorganisms that are beneficial to the host. They mainly exist in the gastrointestinal tract, oral cavity and reproductive system of the host, and can improve the micro-ecological environment in the host, thereby promoting the health of the host. The World Health Organization defines probiotics as microorganisms that, when properly ingested, can have beneficial effects on the body. The concept of probiotics originated from the Greek, meaning "good for life"...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/741A61K36/736A61K36/808A61K36/488A61P1/02A61P11/04A61P29/00A61P31/04A61K31/353A61K31/704A61K31/085A61K31/045A61K31/715
CPCA61K36/82A61K9/2018A61K9/28A61K31/045A61K31/085A61K31/704A61K31/715A61K35/744A61K36/488A61K36/736A61K36/808A61K2300/00
Inventor 陈向东汪辉刘晓雯
Owner NANJING CANCHEN MICROBIAL TECH
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