Docetaxel-loaded nanoporous network fibers prepared by high-voltage electrospinning and their applications

Abstract

The invention discloses a loaded docetaxel nano-pore containing network fiber prepared through high-voltage electrostatic spinning. The loaded docetaxel nano-pore containing network fiber is prepared by mixing polypropylene carbonate, polycaprolactone and docetaxel in a mass ratio of (45-98):(1-40):(1-15), and a conductive metal salt which accounts for 0.2-0.5% of the total mass of the three above materials in a high-voltage electrostatic spinning manner. An electron microscope image shows that the fiber consists of a great amount of nano-pore networks which are communicated with one another, and the specific surface area of the fiber is 130-211m<2> / g. The invention further discloses application of the loaded docetaxel nano-pore containing network fiber in chemotherapy after gliomas operation. The nano-pore networks which are communicated with one another are formed on the surface and inside the fiber disclosed by the invention, the specific surface area of the fiber is greatly increased, the release velocity and the accumulation release amount of a loaded medicine DOC can be also increased, the infiltration depth of the medicine in tumor is remarkably increased, a relatively good anti-tumor effect can be achieved, and furthermore, due to good biocompatibility and biodegradability, and the fiber can be used as a partial slow-release chemotherapeutic medicine in chemotherapy after malignant brain glioma operation, and the preparation method is simple and controllable.

Description

technical field [0001] The invention belongs to the technical field of high-voltage electrospinning fiber and its application, and in particular relates to a docetaxel-loaded nanopore fiber prepared by high-voltage electrospinning and its application. Background technique [0002] More than 60% of primary brain tumors in adults are gliomas. This is a very harmful malignant tumor with high morbidity and mortality. The survival period calculated from the initial diagnosis is only 9-9. 12 months. During the survival period, patients will also lose various functions, such as movement disorders, epilepsy, visual disorders, language disorders, etc., and their quality of life is extremely poor. Although the patients were treated with surgery, radiotherapy and chemotherapy, tumor recurrence occurred almost without exception in the patients. In the past 20 years, there has been no significant progress in the treatment of glioma. At present, the main treatment options are surgical ...

AI Technical Summary

Problems solved by technology

At present, the dosage form on the market in China is injection. Although the curative effect of clinical medication is remarkable, the adverse reactions are also obvious at the same time. The solvent system can cause adverse reactions such as allergic reactions, and gastrointestinal reactions such as nausea, vomiting, or diarrhea may occur; due to the non-selective distribution of the drug, it will cause adverse reactions such as neurotoxicity, musculoskeletal toxicity, and neutropenia. In addition, Tween-80 also has slight hemolytic property and high viscosity. It needs pre-administration of antihistamines and glucocorticoids for clinical medication, which will bring great pain to patients, and it is inconvenient for clinical medication and the safety of medication Low

Images