Preparation method of ceftriaxone sodium

A technology of ceftriaxone sodium and sodium acetate, which is applied in the direction of organic chemistry, can solve the problems of restricting product development prospects, multiple allergies, and high production costs, and achieve the effects of improving overall quality, extraction efficiency, and quality
CN104876948AInactive Publication Date: 2015-09-02NORTH CHINA PHARMA HEBEI HUAMIN PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NORTH CHINA PHARMA HEBEI HUAMIN PHARMA
Publication Date
2015-09-02
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a preparation method of ceftriaxone sodium. The preparation method includes steps of (1) cooling dichloromethane, methyl alcohol and water mixed solvent, adding 7-ACT and AE (active ester) and trimethylamine, controlling the temperature and timing to react; (2) sequentially adding sodium hydrogen sulfite, sodium acetate and sodium hydroxide and stirring; adding extractant, stirring, standing and splitting phase; extracting extractant by water and splitting phase, and combining water phase; (3) adding extractant under water-phase stirring, transferring to and filling in a pressure container, removing air bubbles and vibrating hermetically, and taking out after freezing with temperature controlled; (4) removing organic phase, adding activated carbon after solids are melted, stirring to decolorize, and filtering in a decarbonized and aseptic manner; adding filtrate into solvent to crystalize, filtering, washing, drying and packaging. The preparation method is low in technique cost, moderate and safe in reaction conditions, convenient to operate and facilitates industrial production, and the obtained product conforms to quality requirements and has the advantages of few impurities and good crystal forms.
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Description

technical field

[0001] The invention relates to a preparation method of ceftriaxone sodium, which belongs to the field of medicinal chemistry. Background technique

[0002] Ceftriaxone sodium, also known as ceftriaxone, the original research product name: Rocephine, is a new, long-acting, broad-spectrum third-generation semi-synthetic cephalosporin, belonging to β-lactam antibiotics, by inhibiting the synthesis of bacterial cell walls And play a bactericidal effect. It has strong antibacterial activity against most Gram-positive and negative bacteria. The antibacterial spectrum includes Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Haemophilus influenzae, Enterobacter aerogenes, Proteus, Diococcus and Staphylococcus aureus Wait. Clinically, it is mainly used for meningitis, pneumonia, skin and soft tissue infection, peritonitis, urinary system infection, gonorrhea, liver and gallbladder infection, surgical trauma, sepsis and genital infection of sensitiv...

Claims

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