Hydrogel wound dressing and preparation method and application thereof

Abstract

The invention relates to a hydrogel wound dressing and a preparation process thereof. The finished product of the hydrogel wound dressing is prepared by using gel, a cross-linking agent, a chelating agent, pH regulator, a thickening agent, humectant and a bacteriostatic agent as raw materials, and conducting pH regulation, mixing, secondary pH regulation, drying and other processes. The hydrogel wound dressing and the preparation process have the advantages that cross-linking and curing are conducted on the basis of traditional hydrogel to form the hydrogel wound dressing, and the preparation method is simple and convenient to operate; the prepared hydrogel wound dressing overcomes the defect that water absorption of a hydrogel dressing is insufficient, the mechanical strength of hydrogel is improved, and practicability and the experience feeling are enhanced; the prepared hydrogel wound dressing can provide a wet heal environment and can also absorb a large amount of seepage; a macromolecule hydrophilic material is adopted for hydrogel, no fiber is left when the dressing is replaced, the dressing does not adhere to wound surfaces, pain is relieved, and meanwhile hydrogel is good in biocompatibility and free of toxic and side effects.

Description

technical field [0001] The invention belongs to the field of medical devices, and in particular relates to a hydrogel wound dressing mainly used for treating daily flame burns, hot oil burns, and hot water burns, as well as its preparation method and application. Background technique [0002] The wound dressings currently on the market are generally divided into three categories. The first type is traditional dressings, such as gauze, cotton pads, etc., and the second type is natural biological dressings, including natural collagen dressings and various animal skins, autologous skins or the same. Allogeneic skin, etc., and then synthetic dressings: including films, foams, sprays and hydrogels. Traditional dressings are relatively simple to make, and the price is relatively cheap, but traditional dressings cannot maintain the moisture of the wound surface, resulting in delayed wound healing, and the frequency of traditional dressing replacement is relatively high, and the dre...

AI Technical Summary

Problems solved by technology

Although film-type hydrogel wound dressings have obvious advantages in the therapeutic effect of wound dressings, the viscosity of general film-type hydrogel wound dressings is poor, and a second layer of fixation is needed to ensure its fixation on the wound surface

Jing Xiabin, Yu Haijun and others invented a polyvinyl alcohol hydrogel dressing containing drugs and chitosan and its preparation method. The authorized announcement number is CN1320931C. This method is a relatively common polyvinyl alcohol hydrogel in the market. The preparation method adopts electron beam, ultraviolet, and cobalt-60 gamma ray irradiation hydrogel preparation method. Compared with chemical crosslinking, the irradiation method reduces the use of chemical reagents such as crosslinking agents and chelating agents, and is used as a medical dressing , the irradiation method reduces the reagent toxicity of the dressing, and the polyvinyl alcohol hydrogel greatly improves the mechanical strength of the hydrogel, but the swelling property is poor. In the case of burns, a large amount of exudate will appear on the wound surface. Gel wound dressings are not suitable for such wounds

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