Oral EPA(Eicoeapentaenoic acid) O/W type nanoemulsion and preparation method thereof

Abstract

The invention relates to an oral EPA(Eicoeapentaenoic acid) O / W type nanoemulsion and a preparation method thereof. The product disclosed by the invention is used as a nutritional strengthener. The oral EPA O / W type nanoemulsion is prepared from EPA, EPA ethyl ester or EPA glyceryl ester as well as an oil phase, surfactant, cosurfactant, antioxidant, metal salt and water, wherein the purity of the EPA, EPA ethyl ester or EPA glyceryl ester is greater than or equal to 90wt%, and the EPA, EPA ethyl ester or EPA glyceryl ester accounts for 0.2%-20% of the nanoemulsion in mass percent. The EPA nanoemulsion produced by the method disclosed by the invention has the advantages of high oil content, small particle size distribution, good stability and high transparency, is favorable for digestion and absorption of a human body and can be applied but not limited to beverages, yoghourt, health care oral liquids and medicinal oral liquids.

Description

technical field [0001] The invention relates to an oral EPAO / W nanoemulsion and a preparation method thereof. The product of the present invention is used as a nutrition fortifier. Background technique [0002] EPA (Eicoeapentaenoic acid, eicosapentaenoic acid) belongs to the omega-3 series of long-chain polyunsaturated fatty acids. Current studies have proved that EPA has the following effects: (1) assist obese patients, patients with high blood pressure and hyperlipidemia to maintain high blood fluidity, inhibit abnormal blood coagulation, and effectively prevent stroke, myocardial infarction and thrombosis; (2) ) Help remove cholesterol and hardened plaque attached to the blood vessel wall, reduce blood cholesterol content, maintain good elasticity and permeability of blood vessels; (3) assist people with poor fat metabolism, reduce triglycerides, and avoid fat accumulation , and then prevent the occurrence of arteriosclerosis, peripheral vascular obstruction and damage...

AI Technical Summary

Problems solved by technology

Malondialdehyde produced after EPA oxidation can cross-link proteins, thereby causing muscle loss of elasticity and increasing melanin; free radicals produced by EPA oxidation have carcinogenic effects; lipid oxides produced by EPA oxidation can also cause cardiovascular atherosclerosis, Loss of the lining of blood vessels, making them brittle, which can lead to high blood pressure and cerebral hemorrhage

[0005] At present, most of the EPA-containing medicines, foods, and health products on the market are in the form of capsules or viscous emulsions, and due to the content of EPA, they need to be taken several times a day, which is inconvenient to use

In addition, capsules are difficult to swallow for special groups of people; the taste of viscous emulsion needs to be improved, and the compliance is not good

[0006] Chinese patent CN1345588 discloses "non-pissy fish oil composite microcapsules and its preparation method", which improves the stability of EPA through the form of microcapsules, but due to the use of more auxiliary materials, the EPA content does not increase significantly, and the high-temperature spray drying in the preparation process accelerates Oxidation of EPA

[0007] Chinese patent CN101991534 discloses "EPA ester fat emulsion intravenous injection and manufacturing method", which improves the stability of EPA through high-pressure homogeneous emulsification, but due to the limitations of the injection itself and the possible incompatibility to patients, such as Local redness, swelling, pain, etc., greatly restricting the scope of use

[0008] Chinese patent CN104000212 discloses "a kind of EPA nano-liposome and its preparation method", which makes a liquid oil phase through emulsifiers and lipid materials, and uses lipid nanoparticles to load EPA to protect it from oxidation, but the use of auxiliary materials is relatively low. Many, and the oil phase used in lipid materials increases the burden of liver metabolism

The fish oil used in this patent is "any kind of fish oil sold on the market", and there is also the problem of low content of effective components EPA and DHA. It is unknown whether DHA and EPA can play the expected effect

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