Oral EPA(Eicoeapentaenoic acid) O/W type nanoemulsion and preparation method thereof

A nano-emulsion and nano-emulsion technology, applied in dairy products, applications, milk preparations, etc., can solve the problems of loss of the inner wall of blood vessels, use of many auxiliary materials, hardening, etc. Effect

Inactive Publication Date: 2016-07-06
WUHAN OMEGA BIOMEDICINE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Malondialdehyde produced after EPA oxidation can cross-link proteins, thereby causing muscle loss of elasticity and increasing melanin; free radicals produced by EPA oxidation have carcinogenic effects; lipid oxides produced by EPA oxidation can also cause cardiovascular atherosclerosis, Loss of the lining of blood vessels, making them brittle, which can lead to high blood pressure and cerebral hemorrhage
[0005] At present, most of the EPA-containing medicines, foods, and health products on the market are in the form of capsules or viscous emulsions, and due to the content of EPA, they need to be taken several times a day, which is inconvenient to use
In addition, capsules are difficult to swallow for special groups of people; the taste of viscous emulsion needs to be improved, and the compliance is not good
[0006] Chinese patent CN1345588 discloses "non-pissy fish oil composite microcapsules and its preparation method", which improves the stability of EPA through the form of microcapsules, but due to the use of more auxiliary materials, the EPA content does not increase signific

Method used

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  • Oral EPA(Eicoeapentaenoic acid) O/W type nanoemulsion and preparation method thereof
  • Oral EPA(Eicoeapentaenoic acid) O/W type nanoemulsion and preparation method thereof
  • Oral EPA(Eicoeapentaenoic acid) O/W type nanoemulsion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] (1) Accurately weigh 30g of EPA glyceride with a purity of 92%, control the temperature of the heating medium at 25°C, and mix with 4.1g ethyl linolenate, 0.2g ethyl oleate, 0.150g polyoxyethylene 40 under the conditions of inert gas and 200rpm rotation speed Stir hydrogenated castor oil (RH-40), 100g Tween-80, 70g polyethylene glycol 400, and 0.2g ascorbic acid for 20 minutes to make it fully mixed, then slowly raise the temperature to 55°C to obtain a uniformly dispersed oil phase component, and set aside ;

[0044] (2) Accurately weigh 30g of polyethylene glycol and 1.5g of sodium sulfate into 618g of water, and control the temperature of the heating medium at 50°C. At this time, the stirring speed should be controlled at 300rpm, and the mixing time should be 10 minutes. After mixing evenly, heat up to the pasteurization temperature for pasteurization, and cool down to 40°C to obtain uniformly dispersed water phase components;

[0045] (3) Under an inert gas environ...

Embodiment 2

[0047] (1) Accurately weigh 15g of EPA ethyl ester with a purity of 92%, control the temperature of the heating medium at 25°C, and mix with 3.1g of ethyl linolenate, 0.4g of ethyl palmitoleate, 150g of polyoxyethylene 40 under the conditions of inert gas and 250rpm Stir hydrogenated castor oil (RH-40), 50g Tween-80, 70g ethylene glycol, 30g 1,2-propanediol, 0.25g natural vitamin E, 0.25g tert-butyl hydroquinone for 10 minutes to fully mix Slowly heat up to 55°C to obtain evenly dispersed oil phase components, set aside;

[0048] (2) Accurately weigh 35g of ethylene glycol, 15g of 1,2-propanediol, 1.5g of sodium sulfate, and 1.5g of potassium chloride into 667g of water, and control the temperature of the heating medium at 58°C. At this time, the stirring speed should be controlled at 450rpm. for 8 minutes. After mixing evenly, heat up to the pasteurization temperature for pasteurization, and cool down to 45°C to obtain uniformly dispersed water phase components;

[0049] (3...

Embodiment 3

[0051] (1) Accurately weigh 67g of EPA glyceride with a purity of 96%, control the temperature of the heating medium at 35°C, and mix with 0.32g ethyl palmitoleate, 4.6g ethyl linoleate, 170g lecithin, 110g Tween-20, 107g ethylene glycol, 85g glycerin and 0.78g dibutyl hydroxytoluene were stirred for 25 minutes to make them fully mixed, then slowly heated to 55°C to obtain uniformly dispersed oil phase components, which were set aside;

[0052] (2) Accurately weigh 11g of ethylene glycol, 25g of glycerol, and 9.3g of sodium citrate into 468.2g of water, and control the temperature of the heating medium at 60°C. At this time, the stirring speed should be controlled at 200rpm, and the mixing time should be 15 minutes . After mixing evenly, heat up to the pasteurization temperature for pasteurization, and cool down to 50°C to obtain uniformly dispersed water phase components;

[0053] (3) Under an inert gas environment, stir the oil phase components obtained in step (1) at a sti...

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Abstract

The invention relates to an oral EPA(Eicoeapentaenoic acid) O/W type nanoemulsion and a preparation method thereof. The product disclosed by the invention is used as a nutritional strengthener. The oral EPA O/W type nanoemulsion is prepared from EPA, EPA ethyl ester or EPA glyceryl ester as well as an oil phase, surfactant, cosurfactant, antioxidant, metal salt and water, wherein the purity of the EPA, EPA ethyl ester or EPA glyceryl ester is greater than or equal to 90wt%, and the EPA, EPA ethyl ester or EPA glyceryl ester accounts for 0.2%-20% of the nanoemulsion in mass percent. The EPA nanoemulsion produced by the method disclosed by the invention has the advantages of high oil content, small particle size distribution, good stability and high transparency, is favorable for digestion and absorption of a human body and can be applied but not limited to beverages, yoghourt, health care oral liquids and medicinal oral liquids.

Description

technical field [0001] The invention relates to an oral EPAO / W nanoemulsion and a preparation method thereof. The product of the present invention is used as a nutrition fortifier. Background technique [0002] EPA (Eicoeapentaenoic acid, eicosapentaenoic acid) belongs to the omega-3 series of long-chain polyunsaturated fatty acids. Current studies have proved that EPA has the following effects: (1) assist obese patients, patients with high blood pressure and hyperlipidemia to maintain high blood fluidity, inhibit abnormal blood coagulation, and effectively prevent stroke, myocardial infarction and thrombosis; (2) ) Help remove cholesterol and hardened plaque attached to the blood vessel wall, reduce blood cholesterol content, maintain good elasticity and permeability of blood vessels; (3) assist people with poor fat metabolism, reduce triglycerides, and avoid fat accumulation , and then prevent the occurrence of arteriosclerosis, peripheral vascular obstruction and damage...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K31/202A61P7/02A61P25/00A61P9/10A61P3/06A23L33/12A23C9/13A23L2/52
CPCA61K9/1075A23C9/1315A23L2/52A23V2002/00A61K31/202A61K47/26A61K47/44A23V2250/187
Inventor 刘成广高尚段建利陈澍张志海孙玉洁王颖赵小曼郑昊鲁志鹏卫乐红罗晓刚
Owner WUHAN OMEGA BIOMEDICINE CO LTD
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