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Nano-fibers with drug two-grade pulse releasing function and preparation method thereof

A pulse release and nanofiber technology, applied in the field of materials science, can solve the problem that nanofibers cannot effectively control the secondary pulse controlled release of drugs, and achieve the effects of safe and effective drug controlled release, uniform diameter distribution, and simple preparation process

Inactive Publication Date: 2017-06-20
UNIV OF SHANGHAI FOR SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the above-mentioned technical problems in the prior art, the present invention provides a nanofiber with a secondary pulse release function of a drug and a preparation method thereof, the nanofiber with a secondary pulse release function of a drug and a preparation method thereof To solve the technical problem that nanofibers in the prior art cannot effectively control the secondary pulse controlled release of drugs

Method used

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  • Nano-fibers with drug two-grade pulse releasing function and preparation method thereof
  • Nano-fibers with drug two-grade pulse releasing function and preparation method thereof
  • Nano-fibers with drug two-grade pulse releasing function and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1: Implementation of coaxial electrospinning process and preparation of core-sheath nanofibers

[0029] Co-dissolve 1 gram of ibuprofen and 7 grams of polyvinylpyrrolidone K60 in 100 ml of absolute ethanol to prepare the sheath working fluid.

[0030] 1 gram of drug ibuprofen and 9 grams of fiber-forming polymer hydroxypropyl methylcellulose phthalate are co-dissolved in 100ml of absolute ethanol and methylene chloride mixed solvent (volume ratio 1:1), and the preparation into the core working fluid.

[0031] Put the above-mentioned working fluid into the syringes of the working fluid of the inner core and the outer sheath respectively, install them on the corresponding syringe pumps, and connect them to the two inlets of the coaxial spinning head respectively, connect the high-pressure spinning head and the high-pressure Static generator.

[0032] The injection rate of the core-sheath solution into the coaxial spinneret was controlled by two syringe pumps, th...

Embodiment 2

[0035] Example 2: Structural and Morphological Characterization of Core-Sheath Nanofibers for Secondary Pulse Release of Drugs

[0036] Field scanning electron microscopy (FESEM) was used to observe the surface of the fiber prepared in Example 1 after spraying gold, and the results were as follows image 3 shown. The prepared fiber exhibits a good linear state, no beading structure occurs, the fiber surface is smooth, and the fiber accumulation is uniform. The diameter is 640±90 nm, the distribution is relatively uniform, and the diameter distribution is relatively concentrated.

[0037] The internal structure of the prepared fiber was observed by high-resolution transmission electron microscopy (TEM), and the results were as follows: Figure 4 As shown, the inner and outer layers of the core-sheath nanofiber have a clear structure, and the internal structure of the fiber is as follows Figure 5 As shown, the drug 33 is uniformly distributed in the outer sheath part 11 of t...

Embodiment 3

[0038] Example 3: Functional Analysis of Drug Controlled Release of Core Sheath Nanofibers with Secondary Pulse Release of Drugs

[0039] According to the 2015 edition of Chinese Pharmacopoeia Appendix ⅩD Release Test Method 2, the RCZ-8A intelligent dissolution tester was used to conduct the in vitro dissolution test on the drug-loaded nanofibers obtained above. The control speed is 50rpm, and the temperature is 37±0.1°C. In the first 2 hours, 900 mL of artificial gastric juice without enzymes was used as the dissolution medium, followed by 900 mL of artificial intestinal juice (pH6.8 phosphate buffer solution) without enzymes as the dissolution medium to investigate the drug release properties of nanofibers in vitro. Sampling 5mL at the scheduled time, filtered through a 0.22 µm microporous membrane to obtain the eluate sample, and immediately replenished with the same volume of isothermal fresh medium. After diluting the sample appropriately, at λ=257 nm, UV-Vis spectropho...

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Abstract

The invention provides nano-fibers with a drug two-grade pulse releasing function. Each nano-fiber comprises an inner core part and an sheath part, wherein the sheath part covers the inner core part; the inner core part and the sheath part extend along the length direction; the inner core part is composed of a drug and a polymer pharmaceutical excipient; the sheath part is composed of a drug and a pharmaceutical excipient which is easily dissolved into water. The invention further provides a preparation method of the nano-fibers; the preparation method comprises the following steps: blending the polymer pharmaceutical excipient and the drug of the inner core part to form a co-dissolved solution, and taking the blended solution as working fluid of the inner core part; blending the pharmaceutical excipient which is easily dissolved into the water and the drug of the sheath part to prepare a co-dissolved solution and taking the co-dissolved solution as working fluid of the sheath part; controlling speeds of injecting core and sheath solutions into a coaxial spinning head through two sets of injection pumps respectively; starting up a high-voltage generator and preparing the nano-fibers under the action of high voltage and static electricity. According to the nano-fibers provided by the invention, the sheath part and the inner core part of each nano-fiber adopt polymer matrixes with different dissolving performances, and the carried drugs can be regulated and controlled and be released in a two-grade pulse manner under the supporting of the structure.

Description

technical field [0001] The invention belongs to the field of material science, and relates to a drug sustained and controlled release nanometer material, specifically a nanofiber with a secondary pulse release function of a drug and a preparation method thereof. Background technique [0002] High-voltage electrospinning technology (electrospinning) is a top-down nano-manufacturing technology. The jet is formed by overcoming the liquid surface tension and viscoelastic force of the droplets at the tip of the nozzle by applying an electric field force. Under the joint action of Coulomb force and surface tension, the atomized liquid jet is bent, stretched, and split by high frequency, and is stretched tens of millions of times within tens of milliseconds. After solvent volatilization or melt cooling, nanometer particles are obtained at the receiving end. grade fiber. This technology has simple process, convenient operation, wide selection of materials, and strong controllabilit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K47/32A61K47/38A61K31/192D01F8/10D01F1/02D01D5/00
CPCA61K9/7007A61K9/0002A61K31/192A61K47/32A61K47/38D01D5/0015D01F1/02D01F8/10
Inventor 余灯广王庆李海鹏李娇娇吴迪
Owner UNIV OF SHANGHAI FOR SCI & TECH
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