Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of synthetic method of tazobactamic acid

A technology of tazobactam acid and a synthesis method, applied in directions such as organic chemistry, can solve the problems of long synthesis process steps, many by-products, complicated processes, etc., and achieves the advantages of improving yield and quality, improving quality and reducing reaction temperature. Effect

Active Publication Date: 2019-01-01
SHIJIAZHUANG WANYE CHEM IND CO LTD
View PDF11 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The purpose of the present invention is to provide a kind of synthetic method of tazobactam, to solve the problems of long steps, complicated process, many by-products and low yield in the existing synthetic process

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of synthetic method of tazobactamic acid
  • A kind of synthetic method of tazobactamic acid
  • A kind of synthetic method of tazobactamic acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The synthesis of embodiment 1 compound C

[0032] Put 300mL water, 100mL acetone, 21.63g (0.10mol) 6-APA, 3.82g (0.01mol) hexadecyl trimethylammonium hydrogen sulfate into a 1000mL four-necked flask, stir and cool down to 0~5 ℃, time-consuming Add 33.81g (0.055mol) Oxone (2KHSO) in batches for 30min 5 ·KHSO 4 ·K 2 SO 4 Compound salt), react at 0-5° C. for 2 h, and when HPLC detects that the 6-APA residue is less than 1%, the reaction is terminated to obtain compound A.

[0033] Cool the above reaction system to -20~-10℃, add 50g hydrochloric acid with a mass fraction of 36%, add dropwise 26.4g hypophosphorous acid aqueous solution with a mass fraction of 50% (hypophosphorous acid is 0.20mol), and then dropwise add 46.0 mol of hypophosphorous acid. g 30% aqueous sodium nitrite solution (0.20 mol of sodium nitrite) was dripped, and incubated for 2 hours. When the residual compound A was detected by HPLC to be less than 1%, the reaction was terminated to obtain compoun...

Embodiment 2

[0037] The synthesis of embodiment 2 compound F

[0038] Install a water separator on the 500mL four-neck bottle with a serpentine condenser tube, install a vacuum tube connected to the vacuum pump and a valve for adjusting the air volume on the upper part of the serpentine condenser tube, and put 200mL into the four-neck bottle. Toluene, 38.35g (0.10mol) of compound C, 16.73g (0.10mol) of 2-mercaptobenzothiazole, by adjusting the suction volume, controlling the internal temperature to be 70-80°C, and refluxing under reduced pressure for 3h, to be detected by HPLC that the residue of compound C is less than At 1%, the reaction was terminated. Concentrate to dryness under reduced pressure, add 200 mL of tetrahydrofuran and stir to dissolve, filter off insoluble matter, and concentrate the filtrate to dryness under reduced pressure to obtain Compound D as a white foam.

[0039] Dissolve compound D with 200 mL of dichloromethane, insert an ultrasonic vibrating rod into the react...

Embodiment 3

[0050] The synthesis of embodiment 3 tazobactam acid

[0051] Put 100mL dichloromethane, 50mL acetone, 43.45g (0.10mol) compound F, 16.33g mass fraction of 50% hydrogen peroxide into a 500mL four-neck flask (hydrogen peroxide is 0.24mol), 0.024g sodium polyphosphate (50 % 0.15% of the weight of hydrogen peroxide), cooled to -5~0°C, added 24.50g (0.24mol) acetic anhydride dropwise, exothermic, temperature controlled at 0~5°C, dripping completed, kept for 4h, to be detected by HPLC that the residue of compound F was less than At 1%, the reaction was terminated. 200 mL of 5% sodium sulfite aqueous solution was added to the reaction system, stirred for 10 min, left to stand for layers, the aqueous layer was extracted with 100 mL of dichloromethane, and about 300 mL of the dichloromethane layers were combined to obtain a solution of compound G in dichloromethane.

[0052] Transfer the methylene chloride solution of compound G of the previous step into a 1000mL four-necked flask, a...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a synthetic method of tazobactam acid, comprising the steps of (a) using 6-APA (6-aminopenicillanic acid) as a starting material and cetyltrimethylammonium hydrogensulfate as a catalyst to oxidize with oxone to obtain compound A; subjecting the compound A to deamination reaction to obtain compound B; esterifying the compound B to obtain compound C; (b) subjecting the compound C and 2-mercaptobenzothiazole to reduced pressure backflow to obtain compound D; ultrasonically vibrating the compound D and copper bromide to obtain compound E; reacting the compound E and 1H-1,2,3-triazole to obtain compound F; (c) allowing hydrogen peroxide and acetic anhydride to act on the compound F to obtain compound G; reacting the compound G with anisole to obtain tazobactam acid. Amino groups in 6-APA are diazotized directly, diazo groups are then removed, reduced pressure backflow and ultrasonic vibration are performed, hydrogen peroxide and acetic anhydride are used as oxidants, less byproducts are generated, and the yield and quality of tazobactam acid are effectively increased.

Description

technical field [0001] The invention relates to a method for synthesizing a beta-lactamase inhibitor, in particular to a method for synthesizing tazobactam acid. Background technique [0002] The chemical name for tazobactam acid is: (2S,3S,5R)-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)- 4-Thio-1-azabicyclo[3.2.0]heptane-2-carboxylic acid-4,4-dioxide, molecular formula: C 10 H 12 N 4 O 5 S, molecular weight: 300.29, CAS number: 89786-04-9, structure as follows: [0003] [0004] Tazobactam is a new penicillane sulfone beta-lactamase inhibitor developed by Japan's Dapeng Pharmaceutical Company. In 1992, the combination of tazobactam sodium / piperacillin sodium (1:8) was first listed in France for the treatment of various bacterial infections. Tazobactam has the characteristics of good stability, low toxicity and strong enzyme inhibitory activity, and is the most promising β-lactamase inhibitor in clinical evaluation. Due to the excellent properties of tazobacta...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07D499/87C07D499/04C07D499/08
CPCC07D499/04C07D499/08C07D499/87
Inventor 李宝才潘光荣周强
Owner SHIJIAZHUANG WANYE CHEM IND CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products