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A kind of compound probiotic lactic acid bacteria powder and its preparation method and application

A lactic acid bacteria powder and probiotic technology, applied in the biological field, can solve problems such as increased content of Bacteroidetes, different strains and contents of probiotics, and reduced diversity of intestinal flora, so as to protect nasal cavity infection and improve the body's immunity , Improve the effect of gastrointestinal symptoms

Active Publication Date: 2021-07-27
BEIJING SCITOP BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in recent years, studies have found that the intestinal flora of patients with irritable bowel syndrome has deviated, and the ratio of Firmicutes to Bacteroidetes has increased, including Ruminococcus, Clostridium, Proteus Proteobacteria, Escherichia Coli, Enterococcus, Enterobacter, Prevotella, Dorea, etc. Sex is reduced, in which the number of beneficial bacteria such as Bifidobacterium, Lactobacillus, Bacteroides and Faecalibacterium decreases
From the perspective of regulating intestinal flora, probiotic therapy has made significant progress in recent years, but the curative effect varies due to the different strains and contents of probiotics

Method used

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  • A kind of compound probiotic lactic acid bacteria powder and its preparation method and application
  • A kind of compound probiotic lactic acid bacteria powder and its preparation method and application
  • A kind of compound probiotic lactic acid bacteria powder and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1 Blueberry taste compound probiotic lactic acid bacteria powder

[0035] A method for preparing Lactobacillus plantarum C2 bacterium powder, Lactobacillus casei bacterium powder, Lactobacillus plantarum P-8 bacterium powder, animal Bifidobacterium V9 bacterium powder, comprising the steps:

[0036] (1) Separately carry out high-density fermentation of Lactobacillus plantarum C2, Lactobacillus casei Zhang, Lactobacillus plantarum P-8, and Bifidobacterium animalis V94 strains for high-density fermentation: respectively take a ring of activated Lactobacillus plantarum C2, cheese The slant cells of Lactobacillus Zhang, Lactobacillus plantarum P-8, and Bifidobacterium animalis V9 were respectively inoculated into MRS medium, and cultured at the same temperature of 33-37°C and the same speed of 50-100rpm for 18-24h. Obtain the primary seed solution respectively;

[0037] (2) Transfer the cultivated primary seed liquid into the MRS medium for secondary activation acc...

Embodiment 2

[0048] Example 2 Preparation of Strawberry Taste Compound Probiotic Lactic Acid Bacteria Powder

[0049] Components by weight: 6 grams of Lactobacillus casei bacteria powder, 5 grams of Bifidobacterium animalis V9 bacteria powder, 4 grams of Lactobacillus plantarum P-8 bacteria powder, 5 grams of Lactobacillus plantarum C2 bacteria powder, fructooligosaccharides 50 grams, 30 grams of strawberry powder;

[0050] Select Lactobacillus casei bacteria powder, Bifidobacterium animalis V9 bacteria powder, Lactobacillus plantarum P8 bacteria powder and Lactobacillus plantarum C2 bacteria powder. 9 CFU / g, the number of viable Bifidobacterium animalis V9 6.0×10 9 CFU / g, the number of live bacteria of Lactobacillus plantarum P-8 3.0×10 9 CFU / g, the number of viable Lactobacillus plantarum C2 2.0×10 9 CFU / g;

[0051] Bacteria powder is mixed in advance by weight;

[0052] Select the corresponding weight of lacto-oligosaccharide and strawberry powder to pass through an 80-mesh sieve, ...

Embodiment 7

[0056] Example 7 Effect of Compound Probiotic Lactic Acid Bacteria Powder on Treatment of Irritable Bowel Syndrome

[0057] 1. Research object

[0058] A total of 120 patients with IBS who met the Rome III diagnostic criteria and met the Rome III diagnostic criteria were selected as research objects, aged 18-80 years, regardless of gender. All patients have completed blood and urine routine, liver and kidney function, abdominal ultrasound, chest plain film, gastrointestinal endoscopy, and capsule endoscopy, and no obvious organic changes were found. Exclusion criteria: accompanied by other gastrointestinal lesions, heart, liver and kidney insufficiency, malignant tumors, diabetes, patients with a history of abdominal surgery, pregnant or breastfeeding women, taking drugs that affect the observation of this test within 4 weeks before the test (antibiotics, Traditional Chinese medicine, etc.), autoimmune diseases and those who cannot be followed up on time.

[0059] 2. Experim...

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Abstract

The application provides a compound probiotic lactic acid bacteria powder and its preparation method and application. The compound probiotic lactic acid bacteria powder is composed of Lactobacillus casei bacteria powder, Bifidobacterium animal V9 bacteria powder, Lactobacillus plantarum P‑8 bacteria powder, Lactobacillus plantarum C2 bacteria powder is compounded with prebiotics and fruit and vegetable powder. Compound probiotic lactic acid bacteria powder has a significant protective effect on irritable bowel syndrome, oral infection and nasal infection, and has a significant preventive effect on upper respiratory tract infection. At the same time, it can improve gastrointestinal symptoms, regulate intestinal flora, and improve the body's immunity .

Description

technical field [0001] The invention belongs to the field of biotechnology, and in particular relates to a compound probiotic lactic acid bacteria powder and its preparation method and application. Background technique [0002] The intestine is the largest digestive organ in the human body and plays an important role in digesting food and absorbing nutrients. In the past 15 years, with the rapid development of high-volume sequencing technology and in-depth research on the intestinal tract, the term intestinal flora has appeared more and more frequently in people's sight. Gut flora has been recognized as another important organ of the human body. The human intestinal flora attaches and grows in the nutrient-rich intestine, and plays an important role in metabolizing food for the host, providing energy and nutrients, and inhibiting the growth of pathogenic microorganisms. The intestinal flora has been formed after the host is born, and the intestinal flora participates in th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N1/20A61K35/747A61K36/88A61K36/87A61K36/815A61K36/736A61K36/732A61K36/73A61K36/725A61K36/45A61K36/42A61K36/33A61K36/23A61K36/22A61K36/185A61K9/14A61P1/00A61P11/00A61P1/02A61P11/02A61P37/04C12R1/25C12R1/01C12R1/245A61K35/745A61K31/716A61K31/702A61K31/733
CPCA61K9/14A61K31/702A61K31/716A61K31/733A61K35/745A61K35/747A61K36/185A61K36/22A61K36/23A61K36/33A61K36/42A61K36/45A61K36/725A61K36/73A61K36/732A61K36/736A61K36/815A61K36/87A61K36/88C12N1/20A61K2300/00A61K9/0095A61P31/00A61P1/00A61P11/00
Inventor 张建军马晨王记成
Owner BEIJING SCITOP BIO TECH CO LTD
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