Preparation method of strontium doping hydroxyapatite composite film

A technology of hydroxyapatite and composite film, which is applied in prosthesis, tissue regeneration, medical science, etc., can solve the problems of poor biological activity of bone materials, achieve good biological activity, stimulate osteoblast differentiation, and inhibit reproduction

Inactive Publication Date: 2018-08-24
SHENZHEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The invention provides a method for preparing a strontium-doped hydroxyapatite composite film, aiming to solve the problem of poor biological activity of existing bone materials

Method used

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  • Preparation method of strontium doping hydroxyapatite composite film
  • Preparation method of strontium doping hydroxyapatite composite film
  • Preparation method of strontium doping hydroxyapatite composite film

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preparation example Construction

[0015] The preparation method of the strontium-doped hydroxyapatite composite film provided by the invention mainly includes the following steps:

[0016] Step 1. Mix the strontium salt solution with the calcium salt solution according to the molar ratio of [Sr] / [Sr+Ca] of 0.1~5:100, and according to the molar ratio of P / [Sr+Ca] of 1:1~2 Add the phosphate solution until a precipitate is formed, let stand and age for at least 12 hours, filter with suction, take the filter cake to dry, and place it at 600-1000°C for 2-5 hours to calcinate to obtain strontium-doped hydroxyapatite powder;

[0017] Step 2, mixing chitosan with acetic acid solution, adding strontium-doped hydroxyapatite powder into the chitosan mixture, and stirring to obtain a hydroxyapatite / chitosan suspension;

[0018] Wherein, the mass ratio of chitosan to hydroxyapatite powder is 1-3:3.

[0019] Step 3: Spin-coat the hydroxyapatite / chitosan suspension on the metal substrate and dry to obtain a strontium-doped ...

Embodiment 1

[0037] 1. Substrate pretreatment

[0038] A titanium metal substrate with a size of 10mm×10mm×1mm was polished on any side with 800#, 2000# and 5000# SiC water sandpaper in sequence, and then ultrasonically cleaned with acetone, absolute ethanol and deionized water for 15 minutes each, and then placed in the Dry at 50°C for 2.5 hours.

[0039] 2. Preparation of hydroxyapatite powder

[0040] Mix strontium nitrate solution and calcium nitrate solution according to the molar ratio of [Sr] / [Sr+Ca] at 0.5:100, and titrate and mix with disodium hydrogen phosphate solution according to the molar ratio of P / [Sr+Ca] at 1:1.67 Liquid, utilize sodium hydroxide solution to adjust the pH of the system to be 10.5-11 in the reaction process. Precipitate for 24 hours, filter with suction, take the filter cake, dry it at 60°C for 2 hours, and place it at 700°C for 3 hours to calcinate to obtain strontium-doped hydroxyapatite powder.

[0041] 3. Preparation of hydroxyapatite / chitosan suspen...

Embodiment 2

[0046] 1. Substrate pretreatment

[0047] A titanium metal substrate with a size of 10mm×10mm×1mm was polished on any side with 800#, 2000# and 5000# SiC water sandpaper in sequence, and then ultrasonically cleaned with acetone, absolute ethanol and deionized water for 15 minutes each, and then placed in the Dry at 50°C for 2.5 hours.

[0048] 2. Preparation of hydroxyapatite powder

[0049] Mix strontium nitrate solution and calcium nitrate solution according to the molar ratio of [Sr] / [Sr+Ca] of 1:100, and titrate and mix with disodium hydrogen phosphate solution according to the molar ratio of P / [Sr+Ca] of 1:1.67 Liquid, utilize sodium hydroxide solution to adjust the pH of the system to be 10.5-11 in the reaction process. Precipitate for 24 hours, filter with suction, take the filter cake, dry it at 60°C for 2 hours, and place it at 700°C for 3 hours to calcinate to obtain strontium-doped hydroxyapatite powder.

[0050] 3. Preparation of hydroxyapatite / chitosan suspensi...

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Abstract

The embodiment of the invention provides a preparation method of a strontium doping hydroxyapatite composite film, and relates to the technical field of biological material preparation. The method comprises the following steps of mixing a strontium salt solution and a calcium salt solution according to the mol ratio of [Sr]/[Sr+Ca] being (0.1 to 5):100; adding a phosphate solution according to themol ratio of P/[Sr+Ca] being 1:(1 to 2) until precipitates are generated; performing still standing aging for at least 12h; performing suction filtering; taking filter cake; drying the filter cake; putting the filter cake at the temperature of 600 to 1000 DEG C for calcination for 2 to 5h to obtain strontium doping hydroxylapatite powder; mixing chitosan and an acetic acid solution; adding the strontium doping hydroxylapatite powder into the chitosan mixed solution; performing stirring to obtain hydroxylapatite/chitosan suspension, wherein the mass ratio of the chitosan to the hydroxylapatitepowder is (1 to 3):3; rotationally coating the a metal substrate with hydroxylapatite/chitosan suspension; performing drying to obtain the strontium doping hydroxyapatite composite film.

Description

technical field [0001] The invention belongs to the technical field of biological material preparation, in particular to a method for preparing a strontium-doped hydroxyapatite composite thin film. Background technique [0002] There are more than two million bone grafting operations worldwide every year. Bone implant materials are increasingly used in the medical field. Due to the limited availability of natural bone, people's demand for synthetic bone substitutes is also increasing. For bone surgery, the phase composition, microstructure and biomechanical properties of implant materials are the key to its success. However, not only the above, but also the data of bioactivity and chemical stability of materials are also compared in clinical research. lack. [0003] In clinical practice, bioceramics such as hydroxyapatite (HA) or β-tricalcium phosphate (β-TCP) are widely used. During surgery, if there is no suitable autologous bone graft, hydroxyapatite can be used alone o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/20A61L27/12A61L27/04A61L27/50A61L27/58
CPCA61L27/047A61L27/12A61L27/20A61L27/50A61L27/58A61L2430/02C08L5/08
Inventor 袁秋华张自强徐安平陈泽汇万磊石鑫
Owner SHENZHEN UNIV
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