Capsaicin liquid crystal nano-spray preparation for promoting skin wound healing and preparation method thereof

Abstract

The invention discloses a capsaicin liquid crystal nano spray preparation for promoting skin wound healing and a preparation method thereof. The capsaicin liquid crystal nano spray preparation is prepared from, by weight, 0.1-0.5% of capsaicin, 50-70% of a liquid crystal material, 5-10% of chitosan, 5-10% of a surfactant, 10-15% of a cosolvent and the balance water. The liquid crystal material isformed by mixing phosphatidyl glycerol and glyceryl dioleate in the weight ratio of 1:(1-3). The preparation method of the spray preparation comprises the steps that the capsaicin, the liquid crystalmaterial and the chitosan are dissolved and dispersed to form drug-loaded liquid crystal nanoparticles under the action of the cosolvent, the stability of the drug-loaded liquid crystal nanoparticlescan be greatly improved through the above operation, and the slow-release effect is obvious. The chitosan is combined with cysteine in the body to form a film on an affected part, the chitosan also has an antibacterial effect, the effects of isolating and protecting the affected part are achieved, and the action time of the medicine is prolonged, so that the local medicine concentration is obviously increased, the medicine takes effect easily, and wound healing is promoted.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a capsaicin liquid crystal nano-spray preparation for promoting skin wound healing and a preparation method thereof. Background technique [0002] Skin wound healing has always been a research hotspot in skin and plastic surgery at home and abroad. Skin wound healing is a complex biological process, including three stages: inflammatory response phase, cell proliferation phase, wound maturation and reconstruction phase; among them, the inflammatory response phase: Inflammatory factors such as TNF-α can induce inflammatory cells, fibroblasts and keratinocytes to migrate to the wound site and start wound repair; cell proliferation: fibroblasts, epidermal keratinocytes and endothelial cells promote wound re-epithelialization through migration and proliferation fibroblasts are the main effector cells in skin wound healing; wound maturation and reconstruction period...

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Problems solved by technology

[0003] At present, the main methods of prevention and treatment of hypertrophic scar after trauma repair include the application of compression, silicone products, surgical resection, radiation, freezing, laser, hormone injection and other therapies, but all of them are prone to recurrence or have serious adverse effects

[0004] Capsaicin (capsaicin, CAP) is the main biologically active ingredient in peppers. It is a natural fat-soluble plant alkaloid containing vanillylamide, and its chemical structure is 8-methyl-N-vanillyl-6-nonene Amide (C 18 h 27 NO 3 ), in the form of monoclinic rectangular flaky colorless crystals. Studies have reported that capsaicin has a significant anti-fibrosis effect, which can inhibit the proliferation and collagen synthesis of proliferative fibroblasts; followed by the depletion of neuropeptide P substance, which exerts an anti-scarring effect. Proliferation; Substance P (SP) is an important regulator of tissue repair. SP released from sensory nerve endings when skin is damaged can not only initiate neurogenic inflammatory responses, but also induce a variety of cytokines in fibroblasts (such as TGF -β, EGF, TNF) expression increase, directly or indirectly promote fibroblast proliferation; capsaicin, as a SP depletion agent, exerts the effect of anti-scar hyperplasia; in addition, capsaicin also has another typical clinical effect of inhibiting hypertrophic scars. Symptom-pruritus; However, in the prior art, there are reports in the literature that directly using capsaicin will delay wound healing and produce skin burning pain, which may be related to the local microenvironmental changes at the wound site and the strong irritation of capsaicin; in addition, animal experiments It has been confirmed that the direct application of capsaicin is highly irritating to the skin of rats, leading to suppuration, redness and swelling at the injured part of the skin, enlarging the wound area, and slowing down the wound healing

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