Preparation method and application of cloxacillin molecular composite membrane based on click chemistry imprinting

A technology of cloxacillin and click chemistry, applied in chemical instruments and methods, membrane technology, semi-permeable membrane separation, etc., can solve the problems of lower thermal stability requirements of basement membrane, long and shortened preparation time of molecularly imprinted membranes, etc. , to achieve significant adsorption effect, obvious imprinting effect, and short polymerization reaction time

Active Publication Date: 2019-12-13
JIANGSU UNIV
View PDF9 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the deficiencies in the above-mentioned prior art, the purpose of the present invention is to overcome the technical defects in the prior art, solve the problems of long preparation time, high temperature, and low selectivity of traditional molecularly imprinted membranes, and make the thermal stability of the basement membrane The requirements are greatly reduced, the preparation time is greatly shortened, and the selective separation efficiency of the target molecule (o-cloxacillin) is greatly improved

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method and application of cloxacillin molecular composite membrane based on click chemistry imprinting
  • Preparation method and application of cloxacillin molecular composite membrane based on click chemistry imprinting
  • Preparation method and application of cloxacillin molecular composite membrane based on click chemistry imprinting

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] S1. Preparation of dopamine-modified PVDF basement membrane:

[0057] Dissolve 5g of PVDF powder and 0.1g of polyvinylpyrrolidone in 25mL of organic solvent N,N-dimethylacetamide, stir at 60°C for 12h to obtain a casting solution, let it stand for 20h, and scrape off 0.05mm of Put the PVDF blank membrane into the dopamine hydrochloride aqueous solution with a concentration of 0.5g / L for phase inversion for 18h, take it out and put it into a tris(hydroxymethyl)aminomethane hydrochloride aqueous solution with a pH value of 8 and a concentration of 1g / L for oscillation 3h, after washing with water and drying, the dopamine-modified PVDF basement membrane was obtained;

[0058] S2. SiO 2 Preparation of modified PVDF hydrophilic membrane:

[0059] First prepare a mixed solution of 30mL ethanol and 5mL water, then add 1mL tetraethyl silicate, then add three pieces of dopamine-modified PVDF basement membrane prepared by S1, shake for 3min, then add 0.5mL ammonia water, shake ...

Embodiment 2

[0072] S1. Preparation of dopamine-modified PVDF basement membrane:

[0073] Dissolve 5g of PVDF powder and 0.1g of polyvinylpyrrolidone in 25mL of organic solvent N,N-dimethylacetamide, stir at 80°C for 24 hours to obtain a casting solution, let it stand for 24 hours, and scrape off 0.05mm of Put the PVDF blank membrane into the dopamine hydrochloride aqueous solution with a concentration of 1g / L for phase inversion for 24h, take it out and put it into a tris(hydroxymethyl)aminomethane hydrochloride aqueous solution with a pH value of 8.5 and a concentration of 1.2g / L for oscillation 9h, after washing with water and drying, the dopamine-modified PVDF basement membrane was obtained;

[0074] S2. SiO 2 Preparation of modified PVDF hydrophilic membrane:

[0075] First prepare a mixed solution of 30mL ethanol and 5mL water, then add 1mL tetraethyl silicate, then add three pieces of dopamine-modified PVDF basement membrane prepared by S1, shake for 5min, then add 0.5mL ammonia w...

Embodiment 3

[0088] S1. Preparation of dopamine-modified PVDF basement membrane:

[0089] Dissolve 5g of PVDF powder and 0.1g of polyvinylpyrrolidone in 25mL of organic solvent N,N-dimethylacetamide, stir at 100°C for 36h to obtain a casting solution, let it stand for 28h, and scrape off 0.05mm of Put the PVDF blank membrane into the dopamine hydrochloride aqueous solution with a concentration of 2g / L for phase inversion for 30h, take it out and put it into a tris(hydroxymethyl)aminomethane hydrochloride aqueous solution with a pH value of 9 and a concentration of 1.4g / L for oscillation 12h, after washing with water and drying, the dopamine-modified PVDF basement membrane was obtained;

[0090] S2. SiO 2 Preparation of modified PVDF hydrophilic membrane:

[0091] First prepare a mixed solution of 30mL ethanol and 5mL water, then add 1mL tetraethyl silicate, then add three pieces of dopamine-modified PVDF basement membrane prepared by S1, shake for 10min, then add 0.5mL ammonia water, sha...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
wavelengthaaaaaaaaaa
adsorption capacityaaaaaaaaaa
adsorption capacityaaaaaaaaaa
Login to view more

Abstract

The invention belongs to the technical field of functional material preparation, and particularly relates to a preparation method and application of a cloxacillin molecular composite membrane based onclick chemistry imprinting. The preparation method comprises the following step: by taking dopamine as a bionic modified material, cloxacillin as a template molecule, alpha-methacrylic acid as a functional monomer, pentaerythritol tetra(3-mercaptopropionate) as a cross-linking agent and dipentaerythritol penta- / hexa-acrylate as an assistant cross-linking agent, preparing the cloxacillin molecularly imprinted composite membrane based on a ''click chemistry'' polymerization method. The prepared cloxacillin molecularly imprinted composite membrane effectively overcomes the defects that a conventional cloxacillin molecularly imprinted polymer is difficult to recycle, secondary pollution is prone to being generated and the like, and in addition has a good specific recognition capability and anadsorption separation capability on the cloxacillin.

Description

technical field [0001] The invention belongs to the technical field of preparation of functional materials, and specifically relates to a preparation method and application background technology of a click chemical imprinted cloxacillin molecular composite film Background technique [0002] O-cloxacillin is a β-lactam antibiotic with the characteristics of acid resistance and penicillinase resistance. It has antibacterial activity against Gram-positive cocci and Neisseria. Coccus) enzyme-producing strains have stronger antibacterial activity than oxacillin, and are often used to prevent infection of animal diseases and as growth promoters to improve feed utilization. But the illicit use of ortho-cloxacillin in food animals may pose a potential threat to human health. Many departments such as the World Health Organization, the US Food and Drug Administration and the Ministry of Agriculture of China have banned the abuse of cloxacillin in animal husbandry and aquaculture. The...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): B01D69/12B01D71/34B01D67/00
CPCB01D67/0079B01D69/12B01D71/34
Inventor 孙畅卢健吴易霖董泽清于超秦莹莹孟敏佳李春香闫永胜
Owner JIANGSU UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap