Polyamideimide-polyethylene glycol copolymer derived from L-phenylalanine and preparation method of polyamideimide-polyethylene glycol copolymer
A technology of polyamide-imide and phenylalanine, applied in tissue regeneration, medical science, prosthesis, etc., can solve problems such as degradation, limited biological activity, and low cytotoxicity, and achieve good mechanical properties and biocompatibility Good performance and mild reaction conditions
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Embodiment 1
[0030] A kind of polyamideimide-polyethylene glycol copolymer derived from L-phenylalanine, its preparation method step is as follows:
[0031] 1) 5.8844 grams (0.02mol) of BPDA and 6.6741 grams (0.0404mol) of L-phenylalanine were uniformly dispersed in 75ml of glacial acetic acid to form a homogeneous solution, stirred and reacted at room temperature (25° C.) for 12 hours, and then Heat up to 118°C in an oil bath, and reflux for 5 hours; after the reaction, carry out vacuum distillation to remove the reaction solvent, the distillation temperature is 63°C, and the flow rate is 1-2 drops / second; finally wash the reaction with 5% hydrochloric acid aqueous solution The product was suction filtered three times, and the filter cake was vacuum-dried at 30° C. for 12 hours to obtain an imide diacid monomer based on L-phenylalanine;
[0032] 2) 1.8 g (9.0 mmol) of ODA and 2 g (1 mmol) of polyoxyethylene diamine (Mn=2000), 5.97 g (10 mmol) of the L-phenylalanine-based imide diamine pre...
Embodiment 2
[0065] A kind of polyamideimide-polyethylene glycol copolymer derived from L-phenylalanine, its preparation method step is as follows:
[0066] 1) 5.8844 grams (0.02mol) of BPDA and 6.5750 grams (0.0398mol) of L-phenylalanine were uniformly dispersed in 75ml of glacial acetic acid to form a homogeneous solution, stirred at room temperature (25° C.) for 10 hours, and then Heat up to 125°C in an oil bath, and reflux for 4 hours; after the reaction, carry out vacuum distillation to distill off the reaction solvent at a distillation temperature of 63°C, and finally wash the reaction product 3 times with 5% aqueous hydrochloric acid, and filter it with suction for 30 ℃ vacuum drying for 12 hours to obtain the imide diacid monomer based on L-phenylalanine;
[0067] 2) 1.748 g (9.5 mmol) of BD and 2 g (0.5 mmol) of polyoxyethylene diamine (Mn=4000), 5.97 g (10 mmol) of the L-phenylalanine-based imide prepared in step 1) Diacid monomers in N 2 Add it to 32.2370 g (0.10 mol) of molte...
Embodiment 3
[0076] A kind of polyamideimide-polyethylene glycol copolymer derived from L-phenylalanine, its preparation method step is as follows:
[0077] 1) 5.8844 grams (0.02mol) of BPDA and 6.6113 grams (0.04mol) of L-phenylalanine were uniformly dispersed in 75ml of glacial acetic acid to form a homogeneous solution, stirred and reacted at room temperature (25°C) for 12 hours, and then Heat up to 125°C in an oil bath, and reflux for 4 hours; after the reaction, carry out vacuum distillation to remove the reaction solvent, and the distillation temperature is 63°C; finally wash the reaction product 3 times with 5% aqueous hydrochloric acid, and filter it with suction for 30 ℃ vacuum drying for 12 hours to obtain the imide diacid monomer based on L-phenylalanine;
[0078]2) 2.014 grams (9.5 mmol) of DMMDA and 1 gram (0.5 mmol) of polyoxyethylene diamine (Mn=2000), 5.97 grams (10 mmol) of the imide based on L-phenylalanine prepared in step 1) Diacid monomers in N 2 Add it to 32.2370 g ...
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