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Nano-drug carrier capable of near-infrared light afterglow imaging tracing and preparation thereof

A nano-drug carrier and near-infrared light technology are applied in the field of nano-drug carriers and their preparation to achieve the effects of small size, uniform particle size and good curative effect

Active Publication Date: 2020-02-07
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

These methods have their own advantages and disadvantages, and it is still challenging to find mesoporous carbon nanomaterials with high dispersion, uniform size and shape, tunable pore size and hydrophobicity.

Method used

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  • Nano-drug carrier capable of near-infrared light afterglow imaging tracing and preparation thereof
  • Nano-drug carrier capable of near-infrared light afterglow imaging tracing and preparation thereof
  • Nano-drug carrier capable of near-infrared light afterglow imaging tracing and preparation thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0051] A method for preparing a nano drug carrier capable of near-infrared afterglow imaging and tracking, comprising the following steps:

[0052] 1) Preparation of PLNPs:

[0053] Sodium hydroxide (0.3g), water (4mL), ethanol (9mL) and oleic acid (3mL) were mixed uniformly to obtain a clear and transparent mixed solution, and zinc nitrate aqueous solution, gallium nitrate aqueous solution, chromium nitrate aqueous solution and 28% concentrated ammonia water is slowly added dropwise to dissolve germanium oxide. The total volume of ammonia solution is 3.115mL, and the molar ratio of divalent zinc, trivalent gallium, trivalent chromium and tetravalent germanium metal ions is 1.1:1.8:0.005:0.01 , added to the above mixture, stirred at room temperature for 1 h, the mixture was put into a polytetrafluoroethylene reactor and transferred to an oven, reacted at 220 ° C for 16 h, cooled to room temperature, centrifuged to remove the supernatant, washed with ethanol three times, Cyclo...

Embodiment 2

[0070] A method for preparing a nano drug carrier capable of near-infrared afterglow imaging and tracking, comprising the following steps:

[0071] 1) Preparation of near-infrared luminescent long-lasting nanoparticles:

[0072] Sodium hydroxide (0.3 grams), water (4 milliliters), ethanol (9 milliliters) and oleic acid (3 milliliters) are mixed homogeneously to obtain clear and transparent mixed solution, zinc nitrate aqueous solution, gallium nitrate aqueous solution, chromium nitrate aqueous solution, nitric acid Europium aqueous solution and concentrated ammonia water with a mass fraction of 28% are slowly added dropwise to dissolve germanium oxide. The total volume of the ammonia solution is 3.205 ml, and the molar ratio of metal ions is 1.1:1.8:0.005:0.005:0.01, and added to the above mixed solution , stirred at room temperature for 1 hour, the mixture was put into a polytetrafluoroethylene reactor and transferred to an oven, reacted at 220°C for 16 hours, cooled to room ...

Embodiment 3

[0078] A method for preparing a nano drug carrier capable of near-infrared afterglow imaging and tracking, comprising the following steps:

[0079] 1) Preparation of near-infrared luminescent long-lasting nanoparticles:

[0080]Sodium hydroxide (0.3 grams), water (4 milliliters), ethanol (9 milliliters) and oleic acid (3 milliliters) are mixed homogeneously to obtain clear and transparent mixed solution, zinc nitrate aqueous solution, gallium nitrate aqueous solution, chromium nitrate aqueous solution, nitric acid Praseodymium aqueous solution and concentrated ammonia water with a mass fraction of 28% are slowly added dropwise to dissolve germanium oxide. The total volume of the ammonia solution is 3.205 ml, and the molar ratio of metal ions is 1.1:1.8:0.005:0.005:0.01, and added to the above mixed solution , stirred at room temperature for 1 hour, put the mixed solution into a polytetrafluoroethylene reactor and transferred it to an oven, reacted at 220°C for 16 hours, cooled...

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Abstract

The invention discloses a nano-drug carrier capable of near-infrared light afterglow imaging tracing and preparation thereof, and belongs to the technical field of nano-drug carriers. The preparationof the nano-drug carrier comprises the following steps: preparing carboxylic acid modified near-infrared luminescece long-afterglow nano-particles (PLNPs); dissolving metal salt and organic ligand into an organic solvent to obtain a mixture, then adding the mixture into dispersion liquid of the PLNPs, and completely performing hydrothermal reaction to obtain a PLNPs@MOFs core-shell material; putting the PLNPs@MOFs into a muffle furnace and carrying out calcination; selecting different calcination temperatures and time to obtain a mesoporous carbon nano-cage material which is controlled in specific surface area, is adjustable in pore sizes, can emit near-infrared afterglow light, and is higher in affinity in hydrophobic drugs. According to the nano-drug carrier has an afterglow signal tracing function disclosed by the invention, an in vivo circulation route of the drug carrier capable of in-site-free stimulated near-infrared light afterglow imaging real-time tracing, and storage and slow release of drugs are realized, and the nano-drug carrier has good application prospects.

Description

technical field [0001] The invention relates to a nano-medicine carrier capable of imaging and tracing with near-infrared light afterglow and its preparation, belonging to the technical field of nano-medicine carrier. Background technique [0002] Nano-drug carriers can overcome the limitations of pharmacokinetics brought about by traditional drug molecule preparations, prolong the half-life of drug molecules circulating in the body, and reduce potential side effects caused by direct contact of drugs with organs or cells, thereby increasing drug efficacy and safety. . Due to the characteristics of large specific surface area, large pore volume and large and regular pore size, mesoporous materials have become promising materials in the field of drug delivery. Currently, the most studied nano-drug carriers are mesoporous silicon materials, which are biocompatible and hydrophilic, but have poor affinity for hydrophobic drugs. However, approximately 40% of anticancer drugs are...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/02A61K49/00A61K47/69A61K31/337A61P35/00
CPCA61K31/337A61K47/02A61K47/6923A61K49/0093A61P35/00
Inventor 陈丽建严秀平
Owner JIANGNAN UNIV
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