Titanium monoxide nano-material and preparation method and application thereof

A technology of titanium monoxide and nanomaterials, applied in the field of nanomaterial preparation and biomedicine, can solve the problems of poor controllability of component distribution, unsatisfactory treatment effect, complex synthesis method, etc., and achieve excellent biocompatibility and dispersion properties, regular shape, and high quantum yield

Active Publication Date: 2020-03-17
JE & NA BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although in the prior art there is TiO 2 Nanomaterials are combined or doped with nanoparticles of noble metals, graphene, and other transition metal oxides to form composite nanomaterials, but the therapeutic effect is still unsatisfactory, and the synthesis method is complicated and the controllability of the component ratio is poor. Many problems such as unstable performance need to be improved

Method used

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  • Titanium monoxide nano-material and preparation method and application thereof
  • Titanium monoxide nano-material and preparation method and application thereof
  • Titanium monoxide nano-material and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment A1

[0041] The preparation of embodiment A1, TiO nanometer material

[0042] (1) 110 microliters of TiCl 4 Add to 20mL oleylamine and 10mL octadecene, heat to 140°C for 30min, the purpose is to remove the moisture and oxygen inside;

[0043] (2) Heat the above mixture to 320°C, keep it for 1 hour and then cool it to room temperature;

[0044] (3) The obtained product is precipitated by adding excess ethanol, and then repeatedly washed and centrifuged with dichloromethane to obtain hydrophobic TiO nanomaterials.

[0045] Such as figure 1 It is the X-ray diffraction pattern of the TiO nanomaterial obtained in Example 1, corresponding to the JCPDS standard card 23-1078, which proves that the synthesized product is TiO.

[0046] figure 2It is a transmission electron microscope image of the TiO nanomaterial obtained in Example A1. It can be seen from the image that the sample has a uniform appearance, and the appearance is a uniform rod shape with a size of 1-50 nm.

Embodiment A2

[0047] The preparation of embodiment A2, TiO nanometer material

[0048] (1) 110 microliters of TiCl 4 Add it to 30mL of diaminodiphenylmethane, heat to 140°C for 30min, the purpose is to remove the moisture and oxygen inside;

[0049] (2) Heat the above mixture to 220°C, keep it for 1 hour and then cool it to room temperature;

[0050] (3) The obtained product is precipitated by adding excess ethanol, and then repeatedly washed and centrifuged with dichloromethane to obtain hydrophobic TiO nanomaterials.

Embodiment B1

[0051] Example B1, the surface of TiO nanomaterials is modified with polyethylene glycol

[0052] Take a chloroform solution containing 5 mg of TiO nanomaterial synthesized in A1, then add a chloroform solution containing 25 mg of polyethylene glycol-grafted polymaleic anhydride-1-octadecene (C18PMH-PEG), and ultrasonically mix it completely for 30 minutes; Then perform vacuum rotary evaporation to remove the organic solvent inside to form a thin film; then add ultrapure water and ultrasonically disperse to obtain its aqueous solution; remove the excess polyethylene glycol molecules inside by centrifugal ultrafiltration to obtain polyethylene glycol-modified Aqueous solution of TiO(PEG-TiO) nanomaterials.

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Abstract

The invention discloses a titanium monoxide nano-material and a preparation method thereof. A hydrophobic titanium monoxide nano-material is prepared by a high temperature pyrolysis method; and then amphiphilic molecules are used for modification, so that a titanium monoxide nano-material aqueous solution with good dispersibility is obtained. The obtained titanium monoxide nano material can generate a large amount of active oxygen under an ultrasonic condition and can be effectively used for sonodynamic therapy of tumors; and the sonodynamic therapy effect is obviously superior to that of theexisting commercial nano material. In addition, the invention discloses application of a titanium monoxide nano material in an anti-tumor preparation.

Description

technical field [0001] The invention belongs to the fields of nanomaterial preparation and biomedicine, and in particular relates to a titanium monoxide nanomaterial and its preparation method and application. Background technique [0002] Cancer is still one of the most serious diseases threatening human health, and has become one of the global problems that need to be overcome urgently. Photodynamic therapy (PDT), as a non-invasive treatment method, has achieved good results in the past few decades. However, due to the limited tissue penetration depth of light, PDT is often used to treat relatively small superficial tumors. In addition, severe skin phototoxicity after systemic administration of photosensitizers is another problem facing the clinical application of PDT. [0003] As an alternative to PDT, sonodynamic therapy (SDT) uses ultrasound to trigger the generation of reactive oxygen species from sonosensitizers to kill cancer cells with minimal damage to healthy ti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K33/24A61K47/60A61P35/00B82Y5/00B82Y20/00B82Y40/00
CPCA61K47/60B82Y5/00B82Y20/00B82Y40/00A61P35/00A61K41/0033A61K33/24A61K2300/00
Inventor 刘庄王咸文程亮仲晓燕赵琪
Owner JE & NA BIOTECH CO LTD
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