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Preparation method of PEG-coated porous rare earth phosphate fluorescent nano material

A technology of fluorescent nanomaterials and rare earth phosphates, applied in the field of nanomaterials, can solve the problems of low saturation magnetization, poor MRI imaging effect, poor water solubility, etc., and achieve the effects of mild preparation conditions, excellent fluorescent performance, and enhanced fluorescent performance

Active Publication Date: 2020-04-03
INNER MONGOLIA UNIV OF SCI & TECH
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Problems solved by technology

[0005] There are also many PEG-coated related technologies, such as Chinese Patent Invention Publication No.: (CN109847095A, Application No.: 201811620520.7), which discloses a PEG-coated photosensitizer Preparation method of IR780 modified calcium phosphate bone cement; Chinese patent invention publication number: (CN101903290A, application number: 200880114641.2), which discloses a PEG-coated core-shell silica nanoparticle and its preparation method; Chinese patent Invention publication number: (CN108671233A, application number: 201810545666.3), which discloses the preparation of a polyethylene glycol-polycaprolactone-polyethylene glycol-coated silica / polypyrrole / mesoporous silica drug-loading material ; Chinese patent invention authorization number: (CN103705932B, application number: 201310747523.8), discloses a preparation method of polylactic acid-polyethylene glycol-coated florfenicol nanofibers, which successfully solves the problem of drug loading and solves the problem of Burst release of drugs, short action time and poor water solubility are problems; Chinese patent invention publication number: (CN106983874A, application number: 201710233210.9), discloses a gold nanorod / polyethylene glycol / carbon dot nano-hybrid imaging contrast material and its preparation method
Chinese patent invention authorization number: (CN103405790B, application number: 201310302421.5), which discloses a preparation method of superparamagnetic particles modified in situ by polymers, which successfully solves the problem of low crystallinity and low saturation magnetization of existing commercial contrast agents , the problem of poor MRI imaging effect; Chinese patent invention publication number: (CN11001629A, application number: 20190301352.3), which discloses an antibacterial polishing liquid based on stone polishing and its preparation method; Chinese patent invention publication number: (CN107723833A, application number : 201710962010.7), discloses a preparation method of polyester fiber modified by α-nanometer alumina
[0006] At present, there is no report about PEG-coated porous rare earth-doped phosphate fluorescent nanoparticles with stable and good fluorescent properties

Method used

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  • Preparation method of PEG-coated porous rare earth phosphate fluorescent nano material
  • Preparation method of PEG-coated porous rare earth phosphate fluorescent nano material
  • Preparation method of PEG-coated porous rare earth phosphate fluorescent nano material

Examples

Experimental program
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Effect test

Embodiment 1

[0033] Step 1: Preparation of porous rare earth-doped phosphate fluorescent nanoparticles by hydrothermal method;

[0034] (1) will Sm 2 o 3 , Y 2 o 3 Dissolve in nitric acid with a molar concentration of 3.6mol / L to obtain Sm(NO with a molar concentration of 0.05mol / L 3 ) 3 Solution A and 0.5mol / L Y(NO 3 ) 3 Solution B;

[0035] (2) Sm(NO 3 ) 3 Solutions A and Y (NO 3 ) 3 Solution B is mixed at a volume ratio of 2:9.8 to obtain solution C; add 3mol / L H to solution C 3 PO 4 Obtain reaction system D, make the mol ratio of cation / anion in reaction system D be 1:3;

[0036] (3) Use NaOH solution to adjust the pH value of the reaction system D to 1, and vigorously stir for 30 minutes, and then ultrasonically for 30 minutes to make it fully mixed to obtain the reaction system E;

[0037] (4) Transfer the reaction system E into a reaction kettle with polytetrafluoroethylene, seal it, put it in a dry box, and react for 12 hours in the temperature range of 200 ° C; natur...

Embodiment 2

[0049] Step 1: Preparation of porous rare earth-doped phosphate fluorescent nanoparticles by hydrothermal method;

[0050] (1) the Eu 2 o 3 , Y 2 o 3 Dissolved in nitric acid with a molar concentration of 3.6mol / L to obtain Eu(NO 3 ) 3 Solution A and 0.5mol / L Y(NO 3 ) 3 Solution B;

[0051] (2) Eu(NO 3 ) 3 Solutions A and Y (NO 3 ) 3 Solution B is mixed at a volume ratio of 8:9.2 to obtain a mixed solution C; add 3mol / L of H to the mixed solution C 3 PO 4 Obtain reaction system D, make the mol ratio of cation / anion in reaction system D be 1:3;

[0052] (3) Use NaOH solution to adjust the pH of the reaction system D to 1, and vigorously stir for 30 minutes, and then ultrasonically for 30 minutes to make it fully mixed to obtain the reaction system E;

[0053] (4) Transfer the reaction system E into a reaction kettle with polytetrafluoroethylene, seal it, put it in a dry box, and react for 12 hours in the temperature range of 200 ° C; naturally cool to room tempera...

Embodiment 3

[0060] Step 1: Preparation of porous rare earth-doped phosphate fluorescent nanoparticles by hydrothermal method;

[0061] (1) will Sm 2 o 3 , Y 2 o3 Dissolve in nitric acid with a molar concentration of 3.0mol / L to obtain Sm(NO with a molar concentration of 0.05mol / L 3 ) 3 Solution A and 0.5mol / L Y(NO 3 ) 3 Solution B;

[0062] (2) Sm(NO 3 ) 3 Solutions A and Y (NO 3 ) 3 Solution B is mixed at a volume ratio of 2:9.8 to obtain a mixed solution C; add 3mol / L of H to the mixed solution C 3 PO 4 Obtain reaction system D, make the mol ratio of cation / anion in reaction system D be 1:3;

[0063] (3) Adjust the pH of the reaction system D to 2 with NaOH solution, and vigorously stir for 30 minutes, and then ultrasonically for 30 minutes to make it fully mixed to obtain the reaction system E;

[0064] (4) Transfer the reaction system E into a reaction kettle with polytetrafluoroethylene, seal it, put it in a dry box, and react for 12 hours in the temperature range of 200...

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Abstract

The invention discloses a preparation method of a PEG-coated porous rare earth phosphate fluorescent nano material and belongs to the technical field of nano materials. According to the method, PEG with the average molecular weight of 1000 to 3000 is adopted, and surfaces of porous rare earth phosphate nanoparticles are coated with PEG to prepare the fluorescent nano composite material with a core-shell structure. The material has excellent luminescence property, water solubility and biocompatibility at the same time, the bottleneck problem for the application of a rare earth fluorescent nanomaterial in the aspects of biology, medicine and the like is solved, and the method has the advantages that the preparation method is mild in condition and simple in process and a special environmentis not needed. The prepared water-soluble core-shell structure fluorescent nano material has potential application prospects in the aspects of fluorescence labeling, photothermal therapy, drug carriers, immunoassay, biochips, the detection of germs and microorganisms in food and environment, photobiological imaging and the like.

Description

technical field [0001] The invention relates to a method for coating porous nanoparticles, in particular to a method for preparing a PEG-coated porous rare-earth phosphate fluorescent nanomaterial with good fluorescent performance; it belongs to the technical field of nanomaterials. Background technique [0002] Rare earth elements have unique 4 f Sublayer electronic structure, large atomic magnetic moment, strong spin-orbit coupling, variable coordination number and crystal structure, with rich optical, electrical and magnetic properties; rare earth Sm 3+ Ions have rich and strong light absorption properties in the near-ultraviolet-blue light range, and can excite orange-red fluorescence, which can achieve richer red light emission, and its light absorption range matches the near-ultraviolet light emitted by InGaN chips In recent years, rare earth nanoparticles doped with lanthanide metal ions, which have developed rapidly in recent years, have overcome the defects of orga...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/02C09K11/81A61K41/00A61K47/10A61K47/02G01N21/64
CPCC09K11/02C09K11/7777A61K41/0052A61K47/10A61K47/02G01N21/6428G01N21/6456G01N2021/6439
Inventor 吴锦绣贾恒俊李梅贾慧灵柳召刚胡艳宏
Owner INNER MONGOLIA UNIV OF SCI & TECH
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