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Preparation method of terbinafine hydrochloride liniment

A technology for terbinafine hydrochloride and naphthene liniment is applied in the field of preparation of terbinafine hydrochloride liniment, which can solve the problems of non-moisturizing, demulsification and layering, and difficulty in application of the paste, and achieves less skin irritation and less paste. The effect of small change in body consistency and convenient medication

Inactive Publication Date: 2020-04-28
安徽汇喻科技服务有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing terbinafine hydrochloride cream is unstable and loses water, resulting in a non-moisturizing cream, difficult to apply, slow absorption, and demulsification and layering

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A kind of preparation method of terbinafine hydrochloride liniment, preparation method comprises the following steps:

[0019] Step 1: Prepare materials according to the following formula in parts by weight: 6 parts of terbinafine hydrochloride, 5 parts of benzoic acid, 4 parts of azone, 7 parts of powdered sugar, 5 parts of sodium carboxymethyl starch, 4 parts of Coptidis rhizome, 5 parts of propylene glycol 5 parts of paraffin, 2 parts of Moutan bark extract, 2 parts of sodium lauryl sulfate, 4 parts of glyceryl monostearate, 6 parts of stearyl alcohol, 3 parts of ethyl paraben, 6 parts of seaweed, 5 servings, 3 servings of amomum, 4 servings of cicada slough, 5 servings of water hyacinth fruit, 3 servings of polyoxyethylene fatty acid ester, 5 servings of field onion, 3 servings of Baba flower, 8 servings of white crane ganoderma, 4 servings of Phellodendron chinensis, polysorbate 6 parts of alcohol, 2 parts of sodium ethylenediaminetetramethylene phosphonate, 2 part...

Embodiment 2

[0026] A kind of preparation method of terbinafine hydrochloride liniment, preparation method comprises the following steps:

[0027] Step 1: Prepare materials according to the following formula in parts by weight: 4 parts of terbinafine hydrochloride, 2 parts of benzoic acid, 1 part of azone, 5 parts of powdered sugar, 1 part of sodium carboxymethyl starch, 2 parts of Coptis rhizome, 3 parts of propylene glycol 1 part, 4 parts of paraffin, 1 part of Moutan bark extract, 1 part of sodium lauryl sulfate, 2 parts of glyceryl monostearate, 4 parts of stearyl alcohol, 1 part of ethyl paraben, 5 parts of seaweed, incense 3 servings, 2 servings of amomum, 3 servings of cicada slough, 3 servings of water hyacinth fruit, 1 serving of polyoxyethylene fatty acid ester, 4 servings of field onion, 2 servings of Baba flower, 6 servings of white crane ganoderma, 2 servings of Phellodendron chinensis, polysorbate 5 parts of alcohol, 1 part of sodium ethylenediaminetetramethylene phosphonate,...

Embodiment 3

[0034] A kind of preparation method of terbinafine hydrochloride liniment, preparation method comprises the following steps:

[0035] Step 1: Prepare materials according to the following formula in parts by weight: 9 parts of terbinafine hydrochloride, 8 parts of benzoic acid, 3 parts of azone, 8 parts of powdered sugar, 3 parts of sodium carboxymethyl starch, 5 parts of Coptis rhizome, 6 parts of propylene glycol 4 parts, 7 parts of paraffin, 3 parts of Moutan bark extract, 3 parts of sodium lauryl sulfate, 6 parts of glyceryl monostearate, 8 parts of stearyl alcohol, 4 parts of ethyl paraben, 7 parts of seaweed, incense 7 servings, 4 servings of amomum, 5 servings of cicada slough, 6 servings of water hyacinth fruit, 6 servings of polyoxyethylene fatty acid ester, 7 servings of field onion, 4 servings of Baba flower, 10 servings of white crane ganoderma, 5 servings of Phellodendron chinensis, polysorbate 7 parts of alcohol, 3 parts of sodium ethylenediaminetetramethylene pho...

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PUM

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Abstract

The invention discloses a preparation method of a terbinafine hydrochloride liniment. The preparation method comprises steps as follows: materials are prepared in parts by weight according to a formula in the following; after all materials in the formula are uniformly crushed, the crushed materials are put in a stirrer, 30-40 parts of distilled water are added, and the mixture is mixed and stirredat the stirring speed of 2,500 r / min; after the mixture is uniformly stirred, the mixture is heated to 90-100 DEG C for 30-50 min and then sieved by a sieve of 150 meshes and a filtrate is retained;after the filtrate is concentrated in a vacuum manner to be sticky, and a mixed sticky drug with the relative density being 1.1-1.3 is obtained; the pH value is adjusted to be 3-6, and the drug is stirred uniformly and cooled to the room temperature; the drug is emulsified for 30-50 min until uniformly mixed colloid is obtained, that is, the terbinafine hydrochloride liniment is obtained. The liniment has good glossiness and coating property, paste has small consistence changes with changes of environment temperature and is stable, the drug release speed is high, the transdermal absorption property is good, and compared with a conventional preparation technology, the preparation method has the advantages that the preparation method is simple and easy to operate, quality control is easy, medication is convenient, and the drug has small irritation to skin, good in treatment effect and stable in quality.

Description

technical field [0001] The invention belongs to the field of pharmacy, in particular to a preparation method of terbinafine hydrochloride liniment. Background technique [0002] Terbinafine hydrochloride, its chemical name is (E)-N-(6,6-dimethyl-2-hepten-4-ynyl)-N-methyl-1-carboxamide naphthalene hydrochloric acid. It is an allylamine drug with broad-spectrum antifungal activity. It can specifically interfere with the early biosynthesis of fungal sterols, highly selectively inhibit fungal squalene epoxidase, and hinder the epoxidation reaction of squalene in the process of fungal cell membrane formation, thereby achieving the effect of killing or inhibiting fungi . Applicable to: 1. Consisting of Trichophyton (Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton verrucous, Trichophyton cleavus and Trichophyton violaceum, etc.), Microsporum canis and Epidermophyton flocculus, etc. Infections of the skin, hair and nails. 2. Various tinea diseases (tinea corporis,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/137A61K9/06A61K36/9064A61K47/26A61K47/36A61K47/06A61P31/10A61K35/64
CPCA61K36/718A61K36/71A61K36/65A61K36/02A61K36/8905A61K36/9064A61K35/64A61K36/185A61K36/88A61K36/19A61K36/756A61K36/484A61K36/328A61K36/284A61K36/37A61K31/137A61K9/06A61K9/0014A61K47/26A61K47/36A61K47/06A61P31/10A61K2300/00
Inventor 孔超刘杰欧阳佳龙
Owner 安徽汇喻科技服务有限公司
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