A preparation method of monodisperse high-performance quantum dot fluorescent microspheres

A fluorescent microsphere and quantum dot technology, applied in chemical instruments and methods, luminescent materials, nano-optics, etc., can solve the problems of the influence of surface properties and fluorescent characteristics, the limited luminous ability of a single quantum dot, and the instability of long-term storage. Avoid non-uniformity, uniform size, good uniformity

Active Publication Date: 2021-05-07
SUZHOU WEIDU BIOTECH CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the small size of a single quantum dot, the luminous ability of a single quantum dot is limited, and because of its large specific surface area, long-term storage is unstable, and its surface properties and fluorescence characteristics will also be affected.

Method used

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  • A preparation method of monodisperse high-performance quantum dot fluorescent microspheres
  • A preparation method of monodisperse high-performance quantum dot fluorescent microspheres
  • A preparation method of monodisperse high-performance quantum dot fluorescent microspheres

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preparation example Construction

[0036] A method for preparing monodisperse high-performance quantum dot fluorescent microspheres, comprising the following steps:

[0037] 1) Polystyrene seed microspheres are synthesized by free radical polymerization; prepared by free radical polymerization, including emulsion polymerization, soap-free emulsion polymerization or dispersion polymerization, by adjusting system parameters, such as monomer dosage, initiator dosage, emulsifier / Dispersant type, reaction medium, etc., control the size of the microspheres at 0.5-3um;

[0038] Specifically: in a water bath at 60-75°C, add monomer styrene into the reaction medium dissolved with emulsifier / dispersant, mechanically stir (100-300rpm), add 0.1-2% initiator of total monomer mass Dissolving and polymerizing for 7-24 hours to obtain polystyrene seed microspheres. Among them, the emulsifier / dispersant is sodium lauryl sulfate, sodium dodecylbenzenesulfonate, polyvinylpyrrolidone, polyvinyl alcohol, and the like. The react...

Embodiment 1

[0048] Weigh 0.4g of anhydrous sodium carbonate and 0.4g of potassium persulfate and ultrasonically dissolve them in 500g of deionized water. After the dissolution is complete, add them to a four-neck flask, add 30g of styrene monomer to it, stir mechanically at 200rpm, and place them in a constant temperature water bath at 70°C Reaction 10h. The polystyrene seed microspheres were obtained by centrifuging with ethanol and deionized water successively.

[0049] Weigh 10 g of the polystyrene seed microspheres prepared above, ultrasonically disperse them in 1500 g of 0.5% polyvinyl alcohol solution by mass dispersion, add them into a four-neck flask, keep the constant temperature water bath at 35° C., and mechanically stir at 120 rpm. Weigh 56g of styrene, 7g of aminostyrene, 7g of divinylbenzene, 10g of toluene, and 1.4g of azobisisobutyronitrile in a beaker. After ultrasonic dissolution, add 600g of dodecylsulfuric acid containing 0.2% by mass Sodium and polyvinyl alcohol aque...

Embodiment 2

[0054] Weigh 2 g of polyvinylpyrrolidone and ultrasonically dissolve it in 180 g of absolute ethanol, add it to a four-neck flask, add 20 g of styrene monomer, stir mechanically at 200 rpm, and react in a constant temperature water bath at 70°C for 24 hours. The polystyrene seed microspheres were obtained by centrifuging with ethanol and deionized water successively.

[0055] Weigh 10 g of the polystyrene seed microspheres prepared above, ultrasonically disperse them in 1500 g of 0.5% polyvinyl alcohol solution by mass dispersion, add them into a four-neck flask, keep the constant temperature water bath at 35° C., and mechanically stir at 120 rpm. Weigh 56g of styrene, 7g of aminostyrene, 7g of divinylbenzene, 20g of dibutyl phthalate, and 1.4g of azobisisobutyronitrile in a beaker. After ultrasonically dissolving, add it to 600g of sodium lauryl sulfate and polyvinyl alcohol aqueous solution with a mass fraction of 0.2%, and emulsified under high-pressure homogenization to ob...

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Abstract

The invention relates to a method for preparing monodisperse high-performance quantum dot fluorescent microspheres. First, polystyrene seed microspheres are synthesized by free radical polymerization; then, monodisperse surface functionalized porous is prepared by one-step seed swelling polymerization. Polymer microspheres; then the prepared monodisperse surface-functionalized porous polymer microspheres and quantum dots undergo amide condensation reaction to obtain quantum dot fluorescent microspheres; finally, surface polymer modification of quantum dot fluorescent microspheres , encapsulating quantum dots in polymers. The prepared monodisperse quantum dot fluorescent microspheres have uniform size, uniform fluorescence distribution, high fluorescence intensity and good stability, and improve the stability of the quantum dots while improving the hydrophilicity of the quantum dot fluorescent microspheres and endowing them with functionality.

Description

technical field [0001] The invention relates to a method for preparing monodisperse high-performance quantum dot fluorescent microspheres, and belongs to the technical field of polymer microsphere synthesis. Background technique [0002] At present, quantum dots refer to semiconductor materials composed of II-VI or III-V elements at the nanometer scale, because they have a wider excitation spectrum and narrower emission spectrum than conventional fluorescent dyes, and in chemical fluorescence This field has received extensive attention and research. [0003] The preparation process of quantum dots mainly includes organic phase synthesis and aqueous phase synthesis. Quantum dots synthesized in the organic phase have the advantages of narrow size distribution range, high fluorescence quantum yield, and good stability, but because their surface is oil-soluble, they cannot be directly applied to biological systems, so they need to be modified with ligands. Transferred to the a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C09K11/02C09K11/88B82Y20/00B82Y30/00C08F212/08C08F212/14C08F212/36
CPCB82Y20/00B82Y30/00C08F212/08C09K11/025C09K11/883C08F212/14C08F212/36
Inventor 康英杰宋孟杰杨永喆
Owner SUZHOU WEIDU BIOTECH CO LTD
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