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Antibacterial gel material for dental restoration, and preparation method thereof

A gel material and oral restoration technology, which is applied in the field of medical materials, can solve problems such as lack, and achieve the effects of preventing gel loss, improving acid resistance, and strong acid resistance

Active Publication Date: 2020-12-04
YANTAI BOHAO INFORMATION TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] In summary, although the prior art discloses a variety of oral gels, they are usually used as carriers of drugs or bioactive factors in the oral mucosa, and there are problems such as gel biocompatibility, mechanical strength, and degradability when used as filling materials.
[0014] In addition, in the bone socket or tooth socket after tooth extraction in dental surgery, there is currently no filling gel material on the market that has bactericidal and antibacterial effects, promotes wound healing and antibacterial, so as to inhibit the infection of the affected area when a large number of microorganisms gather in the oral cavity , to promote oral restoration

Method used

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  • Antibacterial gel material for dental restoration, and preparation method thereof
  • Antibacterial gel material for dental restoration, and preparation method thereof
  • Antibacterial gel material for dental restoration, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] Preparation of hydroxypropyl chitosan

[0065] Add 20g chitosan in the three-neck flask, 50mL mass fraction is 15% NaOH solution and Virahol 200mL, stir and alkalize at room temperature for 1h, then add 45mL mass fraction as 10% tetramethylammonium hydroxide solution and 200mL of propylene oxide, stirred at room temperature for 30min, heated to 60°C, refluxed and stirred for 8h, neutralized with hydrochloric acid aqueous solution with a volume ratio of 1:1 to pH = 7, precipitated the product with acetone, and obtained the crude product by suction filtration . The obtained crude product is purified by repeated dissolution and precipitation. Firstly, the obtained crude product is dissolved in deionized water, and then excessive ethanol is poured into it to precipitate the product, filtered, and the purification steps are repeated 2 to 3 times, and dried to obtain hydroxyl Propyl chitosan.

Embodiment 2

[0067] Preparation of Carboxymethylated Hydroxypropyl Chitosan

[0068] Weigh 10g of the hydroxypropyl chitosan prepared in Example 1 and dissolve it in an appropriate amount of distilled water. After stirring at room temperature for 0.5h, add 2 times the molar amount of NaOH solution with a mass fraction of 35%. After stirring for 2h to alkalize, add 150ml of iso After propanol is fully stirred, slowly add chloroacetic acid aqueous solution in batches or dropwise. The molar mass of chloroacetic acid aqueous solution is 4 times that of hydroxypropyl chitosan. , cooled to room temperature, poured out the reaction solution, and removed small molecule impurities by dialysis with a dialysis membrane with a molecular weight of 3Kda, then adjusted the pH to neutral, precipitated and purified the product with acetone, and obtained carboxymethylated hydroxypropyl chitosan sugar.

Embodiment 3

[0070] Preparation of polyethylene glycol-poly-L-lysine

[0071] React 1g of L-lysine and 20% excess triphosgene in 20mL of tetrahydrofuran solvent at 50°C until clear and then react for 1h to transform into the structure of L-lysine-N-carboxy-anhydride. The obtained L-lysine-N-carboxy-anhydride monomer crude product was recrystallized and purified three times from tetrahydrofuran and n-hexane to obtain the final product for use.

[0072] 2g of monomethoxy polyethylene glycol primary amine (Mn=2000g mol -1) in a Schlenk bottle at 50°C in an oil bath for about 6 hours, and then cooled to room temperature; the prepared L-lysine-N-carboxy-cyclic anhydride was dissolved in dry dimethylformamide, and then extracted with a syringe Transfer to Schlenk bottle and react under nitrogen protection and room temperature; Utilize infrared spectrometer to confirm that after reaction is finished, get a small amount of sample and be mixed with 5mg / mL and carry out SEC / LLS (size exclusion chro...

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Abstract

The invention discloses a preparation method of a gel material for dental restoration. The preparation method comprises the following steps of: (1) preparing a double-gel network component; (2) preparing a collagen-based antibacterial gel material component; (3) preparing an auxiliary antibacterial component; (4) preparing a premixed solution; and (5) performing gel forming. The gel material has astrong antibacterial effect; in addition, polyethylene glycol-poly-L-lysine and mineral ions are added in the gel curing process; therefore, the gel has strong acid resistance and good stability in an oral cavity environment; due to the fact that the mineral ions and lone pair electrons on carboxyl and nitrogen atoms in gel molecules form coordination bonds, the solidification time of the gel solution is relatively short; the mechanical strength is good; and meanwhile, the degradation time of the gel is slowed down.

Description

technical field [0001] The invention belongs to the field of medical materials, and in particular relates to an antibacterial gel material used for oral restoration or depression filling and a preparation method thereof. Background technique [0002] In my country, due to the problems of living habits and traditional concepts, people do not pay much attention to oral health care, which leads to oral inflammation and ulceration. In addition, patients who need tooth extraction and implantation are gradually becoming younger. After tooth extraction, inflammation often occurs at the tooth defect and the surrounding gums. After hemostasis and anti-inflammation, it will take several weeks or months for dental implants to stabilize. During this period, a large number of germs and other microorganisms will gather at the tooth defect. Slows down wound healing time. In addition, after the extraction of some teeth such as wisdom teeth, the healing time of the gingival defect in the o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/04A61L31/12A61L31/14A61L31/16
CPCA61L31/148A61L31/145A61L31/16A61L31/047A61L31/123A61L2300/604A61L2300/412A61L2300/41
Inventor 孙文斐
Owner YANTAI BOHAO INFORMATION TECH CO LTD
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