Long-acting superhydrophobic anticoagulation biovalve and preparation method therefor

A biological valve and super-hydrophobic technology, which is applied in the fields of pharmaceutical formulation, tissue regeneration, drug delivery, etc., can solve the problems of thrombus formation, impact on valve durability, and increased risk of stroke, etc., and achieve resistance to thrombosis and stable super-hydrophobic performance , The effect achieved by adsorption

Active Publication Date: 2021-04-13
JILIN VENUS HAOYUE MEDICAL LTD
View PDF6 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the implantation of biological valves in interventional therapy will lead to thrombosis, and the detachment of thrombus on the surface of the va

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Long-acting superhydrophobic anticoagulation biovalve and preparation method therefor
  • Long-acting superhydrophobic anticoagulation biovalve and preparation method therefor
  • Long-acting superhydrophobic anticoagulation biovalve and preparation method therefor

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0031] Example 1

[0032] A preparation method of a long-acting superhydrophobic anticoagulation biological valve, comprising the following steps:

[0033] (1) Pretreatment of the porcine pericardial valve material after glutaraldehyde cross-linking;

[0034] (2) The porcine pericardial valve material treated in step (1) is immersed in a solution containing tannic acid and Cu in a molar mass ratio of 1:0.1 2+ In the ionic buffer solution, the buffer solution is acetic acid-sodium acetate, and its pH is 4. Then, sodium periodate oxidant with a concentration of 20 μM is added to the solution, and the reaction is carried out at 25 ° C for 40 min, so that the tannic acid undergoes an oxidative polymerization reaction at the same time with the tannic acid. Cu 2+ Ion chelation to generate Cu-containing materials on the surface of biological valve materials 2+ of polyphenol nanoparticles;

[0035] (3) The surface contains Cu 2+ The polyphenol nanoparticle porcine pericardial val...

Example Embodiment

[0036] Example 2

[0037] A preparation method of a long-acting superhydrophobic anticoagulation biological valve, comprising the following steps:

[0038] (1) Pretreatment of the porcine pericardial valve material after glutaraldehyde cross-linking;

[0039] (2) immersing the porcine pericardial valve material treated in step (1) in a molar mass ratio of 1:0.05 containing epigallocatechin gallate and Ag + In the ionic buffer, the buffer is glycine-hydrochloric acid buffer, its pH is 4, and then a concentrated nitric acid oxidant with a concentration of 80 μM is added to the solution, and the reaction is carried out at 25 ° C for 60 min to oxidize the epigallocatechin gallate. The polymerization reaction simultaneously with Ag + Ion chelation to generate Ag-containing materials on the surface of biological valve materials + of polyphenol nanoparticles;

[0040] (3) The surface contains Ag + The polyphenol nanoparticle porcine pericardial valve material was soaked in perfl...

Example Embodiment

[0041] Example 3

[0042] A preparation method of a long-acting superhydrophobic anticoagulation biological valve, comprising the following steps:

[0043] (1) Pretreatment of bovine pericardial valve material after glutaraldehyde cross-linking;

[0044] (2) immersing the porcine pericardial valve material treated in step (1) in a molar mass ratio of 1:0.2 containing epicatechin and Ag + In the ionic buffer, the buffer is disodium hydrogen phosphate-citric acid buffer, its pH is 4, then add potassium permanganate oxidant with a concentration of 0.05mM to the solution, and react at 20 ° C for 40 minutes to make epicatechus. The oxidative polymerization of the element occurs simultaneously with Ag + Ion chelation to generate Ag-containing materials on the surface of biological valve materials + of polyphenol nanoparticles;

[0045] (3) The surface contains Ag + The polyphenol nanoparticle bovine pericardial valve material was soaked in octadecanoyl chloride with a molar con...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a long-acting superhydrophobic anticoagulation biovalve and a preparation method therefor. The method comprises the following steps: (1) treating a biovalve material with glutaraldehyde for 48 to 96 hours; (2) embedding nanoparticles, which are polymerized from polyphenol compounds and metal ions and contain double-bond groups, in the surface of the biovalve material; and (3) grafting surfaces of the nanoparticles with a hydrophobic substance, so as to form a hydrophobic coating. According to the long-acting superhydrophobic anticoagulation biovalve and the preparation method therefor, the superhydrophobic coating with a long-acting high water contact angle and a low roll angle is prepared on the surface of the biovalve through a simple and stable operating process without affecting properties of a valve body in accordance with moderate self-polymerization reaction conditions of polyphenols and elicitation of a reaction mechanism of the metal ions, double bonds and mercapto groups, and the requirements on long-acting anticoagulation are met through impeding adsorption of plasma proteins.

Description

technical field [0001] The invention belongs to the technical field of valve material preparation, and in particular relates to a long-acting superhydrophobic anticoagulant biological valve and a preparation method thereof. Background technique [0002] As my country's social population structure enters the aging stage, the number of patients with severe valvular stenosis and regurgitation has increased significantly compared with before. The overall incidence rate of people over 75 years old is relatively high. Once patients have symptoms and have not received treatment, they will die within 2 to 3 years. Closer to 50%. Minimally invasive interventional valve surgery is becoming an important treatment measure accepted by more and more patients because of its small surgical trauma, low risk and good effect. Many corresponding questions. Among them, the implantation of biological valves in interventional therapy will lead to thrombosis, and the detachment of thrombus on the ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61L27/28A61L27/34A61L27/36A61L27/50C08G65/44
CPCA61L27/3625A61L27/3687A61L27/28A61L27/34A61L27/50C08G65/44A61L2400/18A61L2420/04A61L2430/20C08L71/08C08L71/00
Inventor 杨立王云兵罗日方
Owner JILIN VENUS HAOYUE MEDICAL LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap