Hydroxyapatite bone-like material and preparation method thereof

Abstract

The invention discloses a hydroxyapatite bone-like material and a preparation method thereof. The bone-like material comprises hydroxyapatite ceramic particles, a solvent and a dispersing agent, wherein the particle size range of the hydroxyapatite ceramic particles is 0.1-10 microns, and the solid phase content range of the hydroxyapatite ceramic particles is 30-66vol%; the dispersing agent is citrate, polyacrylic acid, ammonium polyacrylate or polyacetylimine; the content of the dispersing agent is 0.1-3% of the mass of hydroxyapatite ceramic particle dry powder; and the bone-like material also comprises trace element substances or medicinal raw materials. The hydroxyapatite bone-like material can be used for preparing a complex and fine micro-scale three-dimensional structure, and does not collapse or break in the forming process; the obtained material can be used for preparing various ceramic special-shaped parts and structural parts and customized products, including medical implants and tissue engineering scaffolds; and the obtained drug-loaded bone-like material can play double roles in repairing bone defects and drug carriers.

Description

technical field [0001] The invention relates to a hydroxyapatite bone imitation material and a preparation method thereof, belonging to the field of preparation and molding of biomedical materials. Background technique [0002] Natural bone is a complex biocomposite material with a precise hierarchical structure. It is jointly constructed by organic and inorganic components. The organic component is mainly Type I collagen, which endows bone tissue with elasticity and toughness. Its inorganic composition is mainly composed of hydroxyapatite, which imparts sufficient rigidity and strength to bone tissue. At the same time, the trace elements contained in natural bone also have an important influence and effect on promoting the growth and function maintenance of bone tissue. [0003] An ideal bone tissue "repair" or "replacement" strategy needs to meet the requirement that the material composition of the implant be equal or close to that of the damaged tissue, the structure of ...

AI Technical Summary

Problems solved by technology

Commonly used antibacterial agents are: antibacterial drugs, such as rifampicin, gentamicin, ciprofloxacin, vancomycin, etc., which can be directly mixed with carrier materials to prepare copolymers; inorganic antibacterial agents, such as silver ions, divalent copper ions, zinc ions, etc., the inhibitory concentration of inorganic antibacterial agents is small, and it is not easy to produce drug resistance, but the preparation process of drug loading is more complicated than that of antibacterial drugs

There are mainly direct deposition method, which directly forms a thin layer of antibacterial material on the surface of the graft, but the antibacterial layer is easy to peel off, and the effect is not long-lasting; ion adsorption method, which uses the principle of positive and negative charge adsorption to adsorb the antibacterial material on the surface of the graft, and the combination is relatively firm. However, the obtained antibacterial materials are difficult to control release; the trap method, which limits the antibacterial agent to the polymer matrix on the surface of the material, can release high concentrations of antibacterial drugs in a short period of time, but the composition of the polymer matrix is ​​complex and the drug loading capacity is limited. , the action time is not long-lasting

It can be seen that the anti-infection modification of the surface of the implant cannot solve the problem of secondary infection of the implant well.

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