Preparation method of oxygenation membrane with anticoagulant coating, catheter and intubation tube

A coating and oxygenation technology, applied in catheters, coatings, anticoagulant treatment, etc., can solve the problems of difficult to build a coating with high blood compatibility, and achieve the prolongation of thromboplastin time, firm adhesion, and reaction Simple process effect

Pending Publication Date: 2022-05-13
TIANJIN POLYTECHNIC UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing oxygenated membrane materials mainly include polymethylpentene and polypropylene. Both membrane materials have a common problem: due to the chemical inertness of the surface of the membrane material, it is difficult to construct a high blood pressure on the membrane surface by chemical grafting reaction. Compatible Coating

Method used

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  • Preparation method of oxygenation membrane with anticoagulant coating, catheter and intubation tube
  • Preparation method of oxygenation membrane with anticoagulant coating, catheter and intubation tube
  • Preparation method of oxygenation membrane with anticoagulant coating, catheter and intubation tube

Examples

Experimental program
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Effect test

Embodiment 1

[0053] Step 1, put 11wt% polyvinyl chloride resin, 10wt% polyethylene glycol (molecular weight 4000) and 79wt% solvent dimethylacetamide into the spinning kettle, stir at 60°C for 10 hours to dissolve evenly, and let it stand for defoaming After 4 hours, it was extruded together with the core liquid (aqueous solution of 70 wt% dimethylacetamide) through an inserted tubular spinning nozzle, and entered into a coagulation bath water tank. At a spinning and drafting speed of 50 m / min, polyvinyl chloride hollow fiber membranes were spun, washed with water, and dried at room temperature directly to obtain polyvinyl chloride oxygenated membrane substrates. The inner diameter of the polyvinyl chloride oxygenated membrane substrate is 200 μm, the wall thickness is 40 μm, and the gas permeation rate is 35 mL / min cm 2 ·bar, the water penetration pressure is 0.52MPa, the maximum pore size measured by ethanol bubble point method is 0.05μm, and the porosity is 83%.

[0054] Step 2: On the...

Embodiment 2

[0062] Step 1. Put 21wt% polyvinylidene fluoride-chlorotrifluoroethylene resin, 10wt% polyethylene glycol (molecular weight 400) and 69wt% solvent N-methylpyrrolidone into the spinning kettle, stir at 90°C for 6 hours to dissolve After standing for 4 hours for defoaming, it is extruded together with the core liquid (70wt% N-methylpyrrolidone aqueous solution) through the inserted tubular spinning nozzle and enters the coagulation bath water tank. At a spinning and drawing speed of 45 m / min, polyvinylidene fluoride-chlorotrifluoroethylene hollow fiber membranes were spun, washed with water and dried at room temperature directly to obtain polyvinylidene fluoride-chlorotrifluoroethylene oxygenated membrane bases material. The inner diameter of the polyvinylidene fluoride-chlorotrifluoroethylene oxygenated membrane substrate is 200 μm, the wall thickness is 40 μm, and the gas permeation rate is 100 mL / min cm 2 ·bar, the water penetration pressure is 0.32MPa, the maximum pore size...

Embodiment 3

[0069] On the inner surface of the polyvinyl chloride catheter or cannula prepared by the conventional plastic extrusion method, a solution of tetraethylenepentamine solution with a concentration of 2mol / L is passed through, and the temperature is 60°C, and the reaction time is kept for 8 hours, and then deionized Rinse the inner surface of the catheter or cannula with water, then pass through a citric acid aqueous solution with a concentration of 0.8 mol / L, and keep the reaction time at room temperature for 8 hours.

[0070] The bovine serum albumin adsorption rate of the catheter or cannula is less than 0.5%, and the hemolysis rate is less than 0.3%. After citric acid graft modification, the APTT value was 2.9 times that of the blank control group.

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Abstract

The invention relates to a preparation method of an oxygenation membrane with an anti-coagulation coating, a catheter and an intubation tube, the oxygenation membrane is a hollow fiber hydrophobic membrane with the inner diameter of 200 mu m, the wall thickness of 30-60 mu m, the gas permeation rate of 20-200 mL / min.cm < 2 >. Bar and the water permeation pressure of 0.30-0.80 MPa, and polyvinyl chloride resin or polyvinylidene fluoride-trifluorochlor oethylene copolymer resin is used as a base material of the membrane to prepare the hollow fiber hydrophobic membrane with the inner diameter of 200 mu m, the wall thickness of 30-60 mu m, the gas permeation rate of 20-200 mL / min.cm < 2 >. Bar and the water permeation pressure of 0.30-0.80 MPa. The base material of the catheter or the cannula is medical polyvinyl chloride resin. The method comprises the following steps: introducing an aqueous solution of a polyamine small molecule compound with the concentration of 1-10mol / L into the inner surfaces of substrates of an oxygenation membrane, a catheter and an intubation tube, and keeping the reaction for 4-10 hours at the temperature of 60-90 DEG C; washing the inner surface of the base material with deionized water; and finally, introducing an aqueous solution of a polycarboxylic small molecular compound with the concentration of 0.1-1 mol / L, and reacting at room temperature for 4-48 hours. According to the oxygenation membrane, the catheter or the cannula, the bovine serum albumin adsorption rate is reduced, the hemolysis rate is reduced, the time for activating partial thromboplastin is prolonged by three times, and the blood compatibility of the catheter, the cannula and the oxygenation membrane is effectively improved.

Description

technical field [0001] The invention belongs to the field of medical materials, and in particular relates to a preparation method of an oxygenated membrane, a catheter and an intubation tube. Background technique [0002] Oxygenated membranes, catheters and cannulas, as materials in direct contact with blood, have high requirements for their blood compatibility. Due to the insufficient anticoagulant properties of these materials in clinical treatment at present, it is usually necessary to artificially inject anticoagulants to maintain the normal flow of blood in extracorporeal circulation circuits and blood purification devices. Therefore, improving the anticoagulant performance of biomaterials is a demand in the field of biomedicine in practical applications. The hemocompatibility of biocontact materials can be improved by constructing coatings on the surface of biomaterials. [0003] The current anticoagulation coating materials mainly include: heparinized coating materia...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L29/04A61L29/08A61L29/14A61L33/04A61M1/16A61M1/36
CPCA61L29/041A61L29/085A61L29/14A61L33/0088A61L33/04A61M1/3666A61M1/1621A61M1/1698A61M1/3621A61M1/3659A61M2202/0413A61M2202/0021C08L27/12C08L27/06
Inventor 吕晓龙杨可荣新雨龙婷婷
Owner TIANJIN POLYTECHNIC UNIV
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