One-step preparation process of aseptic ceftriaxone sodium for injection

A technology for ceftriaxone sodium and a preparation process, which is applied in the field of compound preparation, can solve the problems of large solvent usage, high production cost, high labor intensity and the like, and achieves less solvent usage, low production cost and low labor intensity. Effect

CN1765902AActive Publication Date: 2006-05-03REYOUNG PHARMA

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Patent Information

Authority / Receiving Office: CN · China
Current Assignee / Owner: REYOUNG PHARMA
Publication Date: 2006-05-03

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Abstract

The invention relates to an improved preparation technique for Ceftriaxone Sodium, which comprises: with nitrogen protection, in solvent, reacting between 7-ACT and AE-active ester with amine as intermediate; adding benzothiazole as assisting solvent and sodium salt agent, separating and crystallizing to obtain the product. Wherein, the reaction solvent comprises halogenated hydrocarbon of alkane, acetic ester or acetone and alcohol and water; stirring the 7-ACT and AE-active ester till clear, adding assisting solvent of benzothiazole and salt agent; extracting, degerming, filtering, adding insoluble solvent for Ceftriaxone Sodium; when liquid shows turbid, feeding crystal; separating the crystal by insoluble solvent to cefotaxime sodium; cleaning, drying treatment to obtain the product for injection. This invention needs just one-step operation, has good crystallization and short production period, improves product yield, and decreases solvent harm to operation crews.

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Description

technical field

[0001] The invention relates to an improved preparation process of ceftriaxone sodium, which belongs to the technical field of compound preparation. Background technique

[0002] Ceftriaxone sodium is the third-generation broad-spectrum cephalosporin, which is widely used in respiratory tract infections and urinary system infections sensitive to this product, including pyelonephritis and gonorrhea, sepsis, meningitis, burn infection, postoperative infection, bone and joint, Soft tissue, skin and wound infection, abdominal infection (peritonitis, bile duct and gastrointestinal tract infection), etc., and infection prevention during surgery. The existing ceftriaxone sodium preparation process is operated in two steps, protected by nitrogen, in a single solvent of dichloromethane, reacted by 7-ACT and AE-active ester under the effect of triethylamine intermediate reactant, adding benzene And thiazole co-solvent, and then add salt-forming agent to obtain crystal...

Claims

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