30 results about "Ce antigen" patented technology

The present invention provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for the membrane-anchored, 4O.kDa mesothelin polypeptide, which is overexpressed in several tumors, such as pancreatic and ovarian tumors, mesothelioma and lung cancer cells. These antibodies, accordingly, can be used to treat these and other disorders and conditions. Antibodies of the invention also can be used in the diagnostics field, as well as for further investigating the role of mesothelin in the progression of disorders associated with cancer. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use.

The invention discloses an amino acid sequence for detecting a tumor marker P16 antigenic epitope and application of the amino acid sequence, and belongs to the technical field of immunology. The invention provides an antigenic amino acid sequence of a tumor anti-cancer gene P16. The P16 polypeptide antigen is used for detecting corresponding specific antigenic epitope in the blood of a patient with lung cancer and esophagus cancer; the antigenic epitope can be used as a tumor marker for estimating the degree of risk for occurring the lung cancer and the esophagus cancer. And the antigenic polypeptide and an antibody thereof can be used for preparing tumor early-diagnosis reagent and developing a targeted drug for treating the tumors.

The present invention provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for human and Macaca fascicularis CEACAM6 (Carcinoembryonic antigen-related cell adhesion molecule 6, CD66c, Non-specific crossreacting antigen, NCA, NCA-50 / 90), and which do not significantly cross-react with the closely related human CEACAM1, human CEACAM3, and human CEACAM5. The invention further provides methods to generate this kind of antibodies. The antibodies, accordingly, can be used to treat cancer and other disorders and conditions associated with expression of the CEACAM6. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use.

The present invention provides antigen-binding polypeptides (e.g., bi-specific antigen-binding polypeptides) that specifically bind to a first and a second target antigen with high affinity. The present invention also provides novel antigen-binding polypeptides that specifically bind to HER2 and antagonize HER2 activation. The invention also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen binding polypeptides. Methods of using antigen-binding polypeptide of the invention to treat disease (e.g., cancer) are also encompassed by the invention.

The invention provides a triple antigen and antibody complex for preventing and controlling porcine viral diarrhea and a preparation method of the triple antigen and antibody complex. The triple antigen and antibody complex comprises an antigen and an antibody, wherein the antigen is a triple virus liquid obtained by mixing porcine transmissible gastroenteritis viruses, porcine epidemic diarrhea viruses and porcine rotavirus, and the antibody is a triple egg yolk antibody prepared on the basis of the antigen. The triple antigen and antibody complex for preventing and controlling porcine viral diarrhea is convenient and quick to use and capable of safely and effectively preventing and controlling the porcine viral diarrhea. The triple antigen and antibody complex can effectively reduce the body immunological stress response, increases the protection production speed, rapidly increases the body antibody titer and is prevented from the virus diffusion risk in production and use processes.

The present invention provides an antigen binding polypeptide which specifically targets the synovial microvasculature of arthritis patients and comprises one or more complementarity determining regions (CDRs) selected from the group consisting of SEQ ID NOs 1 to 4. The present invention also relates to the use of such antigen binding polypeptides and conjugates thereof for use in the diagnosis and treatment of arthritis.

The epitope amino acid sequence for detecting liver cancer marker IMP1 and an application thereof belong to the technical field of immunology. The invention provides an epitope amino acid sequence of liver cancer related gene IMP1. An IMP1 polypeptide antigen is applied to detect corresponding specific autoantibodies in the blood of a patient with liver cancer, and the autoantibody can be used as a liver cancer marker to assess risks of liver cancer and prognostic effect. The antigenic polypeptide and antibody thereof can be used to prepare reagents for early diagnosis of liver cancer and prognosis and to develop a targeted drug for liver cancer treatment.

The invention discloses an epitode amino acid sequence of TFG-beta1 (transforming growth factor beta-1) as a breast cancer detecting marker and application of the epitode amino acid sequence, belongs to the technical field of immunology, and provides the antigen amino acid sequence of a breast cancer-related gene TFG-beta1. The TFG-beta1 polypeptide antigen can be applied to detection of the corresponding specific autoantibody in the blood of a breast cancer patient, the autoantibody can be used as the breast cancer marker for evaluating the degree of risk of breast cancer occurrence, and the antigenic polypeptide and the antibody thereof can be used for preparing a reagent for early diagnosis of breast cancer and developing a target medicine for treating breast cancer.

The invention discloses a tumor marker FOXP3 auto-antibody and an application thereof, belonging to the technical field of immunology. The invention provides an antigen amino acid sequence of an immune response regulating gene FOXP3. An FOXP3 peptide antigen is used for detecting corresponding specific auto-antibodies in blood of patients suffering from lung cancer and esophageal cancer, and the auto-antibodies can be taken as tumor markers for evaluating the occurrence risks of lung cancer and esophageal cancer. An antigen polypeptide and an antigen thereof can be used for preparing tumor early diagnosis reagents and developing a targeting medicament for treating tumors.