The invention belongs to the field of voice noise reduction, and discloses a single-track voice noise reduction method, system and device, and a readable storage medium, and the method comprises the steps: obtaining to-be-denoised single-track voice; constructing an initial noise reduction model based on an LSTM neural network; obtaining a preset number of enhanced training samples, and training the initial noise reduction model by adopting the preset number of enhanced training samples to obtain a noise reduction model; and denoising the to-be-denoised single-track voice through the noise reduction model, so that a human voice audio can be obtained. The noise reduction process is not limited by double channels, noise reduction processing of any single-track voice can be realized, model training is performed on the basis of the LSTM neural network on the basis of the characteristic that the noise types of the whole time sequence in the same voice are approximately the same, the noise law of the whole time sequence is convenient to learn, and therefore, a good noise reduction effect is achieved. Meanwhile, based on the complexity of the noise influence factors, the initial noise reduction model is trained again by the enhanced training samples, and the noise reduction effect of the noise reduction model is further improved.