The invention discloses an intelligent comprehensive examination management system. The system includes a server, a database, multiple teacher terminals, examination affair terminals, multiple examination paper printing and bookbinding terminals, multiple barcode printers, an examination paper reading and appraising unit, grade input units, a grade statistics unit and system management units. Theteacher terminals are installed in PC sides respectively and are in communication with the server separately, and each teacher terminal consists of an examination question submitting unit, an answer sheet making unit and a reference answer submitting unit; the examination affair terminals are installed in the PC sides and are in communication with the teacher terminals through the server; the examination paper printing and bookbinding terminals are in communication with the examination affair terminals; the barcode printers are in communication with the examination affair terminals respectively; the examination paper reading and appraising unit consists of an objective item automatic paper inspection module, a subjective item intelligent paper inspection module and a subjective item manualonline paper inspection module; the grade input units are arranged in the teacher terminals; the grad statistics unit is arranged in the server; the system management units are arranged in the examination affair terminals. The system can provide convenience for teachers to remotely submit examination paper, reduce the error rate of manual work and alleviate the paper inspection load of teachers and is high in automation degree.