The invention discloses traditional Chinese medicine and western medicine combined atomization administration equipment which structurally comprises an operation box, a control button, a respirator and a closing cover, the closing cover is installed on the operation box, the operation box is in clearance fit with the closing cover, the control button is installed on the operation box, the operation box is movably connected with the control button, the respirator is installed on the operation box, and the control button is movably connected with the control button. The two liquid cavities are formed in the device, when a patient needs to replace liquid medicine for atomization, the closed blocks are adjusted, circulation holes of the liquid cavities are opened, atomization of the replaced liquid medicine can be achieved, it is not needed to replace another atomization medicine feeding device for liquid medicine replacement, the replacement pipe can be detached and installed, and the replacement pipe is convenient to use. After a patient finishes using the disposable disposable replacement tube, the replacement tube can be detached and replaced with a brand new tube body, the disposable use of the replacement tube is achieved, and the situation that due to the fact that the hole diameter of the tube body of the replacement tube is small, the replacement tube is difficult to clean thoroughly, liquid medicine remains in the tube body, and liquid medicine cross contamination is caused is avoided.