Suture thread containing bioactive components and preparation method thereof

A bioactive ingredient and suture technology, applied in the field of medical sutures and their preparation, can solve problems such as difficult controlled release of drugs, and achieve the effect of avoiding wound infection and reducing infection

Inactive Publication Date: 2009-04-15
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The commonly used method is to directly coat the drug on the surface of the suture. Although it has a certa

Method used

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  • Suture thread containing bioactive components and preparation method thereof
  • Suture thread containing bioactive components and preparation method thereof
  • Suture thread containing bioactive components and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Example 1: Preparation of sutures with releasable antibiotics that promote coagulation

[0043] (1) Preparation of raw material solution

[0044] Shell layer: The biodegradable material is L-polylactic acid (PLLA), and the solvent is trifluoroethanol. A certain mass of L-lactic acid is weighed, dissolved in a solvent to form a shell spinning solution with a concentration of 8wt%, and ultrasonically Medium shaking for 4-5 hours to obtain a transparent and uniform shell spinning solution;

[0045] Core layer: the bioactive ingredient is cefotaxime sodium, and the solvent is deionized water. Different qualities of cefotaxime sodium are weighed and dissolved in solvents respectively to make core materials with concentrations of 10wt%, 20wt%, and 30wt% for spinning solution;

[0046] Coating: biodegradable material chitosan (deacetylation degree 80%, molecular weight about 100,000), solvent is 1% acetic acid solution, chitosan is dissolved in the solvent to form a concentr...

Embodiment 2

[0058] Example 2: Preparation of sutures with the effect of releasing anticancer drugs

[0059] (1) Preparation of raw material solution

[0060] Shell layer: the biodegradable material is polycaprolactone (PCL), the solvent is chloroform: acetone with a volume fraction of 2:1, polycaprolactone is dissolved in the solvent, and the solution is placed in a water bath constant temperature tank, It can be dissolved in a water bath at 60°C for 2 hours, and the PCL concentration is kept at 7wt% to obtain a shell spinning solution;

[0061] Core material: the bioactive component is resveratrol (RT), and the solvent is absolute ethanol. Resveratrol (RT) is dissolved in the solvent, dissolved under magnetic stirring, and the control concentration is 10wt%, and the core material is obtained spinning solution;

[0062] Coating: The solute of the coating is lactic acid / glycolic acid copolymer (PGLA910), and the solvent is acetone. The solute is dissolved in the solvent to prepare a solu...

Embodiment 3

[0072] Example 3: Preparation of medical sutures that can release growth factors

[0073] Fibroblast culture, subculture and identification:

[0074] Wash the bloodstained fresh skin after surgery, remove the epidermis and subcutaneous tissue, and cut it into 0.15-1mm under sterile conditions 3 Tissue pieces attached to the bottom of the culture flask, at 37°C, 5% CO 2 Culture the cells in a static incubator for 4 hours, add DMEM culture solution containing 20% ​​FBS, 100mg / L penicillin, and 100mg / L streptomycin, continue to cultivate, and change the medium once every 4 to 6 days with DMEM containing 20% ​​FBS , subcultured after 3-4 weeks of culture. Fibroblasts were identified by cell morphology.

[0075] (1) Preparation of raw material solution

[0076]Shell layer: The biodegradable material is lactic acid-polyglycolic acid copolymer (PLGA910), the solvent is 3:1 tetrahydrofuran and N,N-dimethylformamide, and the shell layer spinning concentration is 0.2g / ml. Shake the...

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Abstract

The invention relates to a suture line containing bioactive ingredients and a preparation method thereof. The suture line is prepared by a plurality of superfine fibers with biocompatibility through the coaxial cospinning technology and after-treatment, and the plurality of the superfine fibers are biodegradable materials, wherein at least one superfine fiber is a composite superfine fiber with acore-shell structure; a core comprises the bioactive ingredients; and a shell is a biodegradable material. The suture line containing the bioactive ingredients has the advantages that the suture linecontaining the bioactive ingredients aims to realize wound suture and avoid wound infection caused by secondary operation; the biodegradable materials are taken as substrate materials and as shell layer materials of the coaxial cospinning composite superfine fibers, and different bioactive ingredients are packaged into core layers; and the diameter, the structure and the mechanical property of the suture line and the release property of a medicine and so on are controlled by adjustment of the processing parameters, so that the prepared suture line meets the suture requirements of various different tissues, not only can suture the wound but also can reduce infection, and has the function of treatment.

Description

technical field [0001] The present invention relates to a medical suture and a preparation method thereof, more specifically to a suture with a core-shell composite microfiber structure constructed by coaxial co-spinning technology and releasable bioactive components and a preparation method thereof . Background technique [0002] Medical suture is a kind of sterile thread used for wound suturing, tissue ligation and fixation, and plays a role in reducing tension and abutting tissues during wound healing. After surgical sutures enter the body, the sutures will be regarded as "foreign objects" by the immune system and cause immune rejection by the human body. As a substance implanted into the body from the outside, it often causes different degrees of inflammatory reactions in the body, which can easily cause wound infection. The implantation of sutures makes it possible for bacteria to take advantage of them. In addition, the knots of the sutures also provide convenience f...

Claims

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Application Information

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IPC IPC(8): A61L17/12A61L17/10A61L17/00
Inventor 黄争鸣胡雯
Owner TONGJI UNIV
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