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Complex preparation for regulating lipid and preventing and curing heart cerebrovascular diseases and preparation method thereof

A dosage form and composition technology, applied in the field of health care or pharmaceutical compound preparations and its preparation, can solve problems such as skin erythema, heat sensation, itching, blood viscosity dilation of blood vessels, obvious side effects, etc., and achieve simple and easy preparation process and visceral function Harmonized, broad application prospect effect

Inactive Publication Date: 2009-12-30
湖南福湘生物技术有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the drugs used to regulate blood lipids mainly include: 1. Phenoxyaromatic acids, whose main function is to lower triglyceride and cholesterol, but often have adverse reactions such as nausea, abdominal distension, diarrhea, and leukopenia; Cholesterol-based, strong lipid-lowering effect, quick onset, but headache, insomnia, nausea and other adverse reactions; 3. Niacin, which has a strong effect on lowering serum triglycerides, but is prone to skin erythema, heat, and itching ; 4. Unsaturated fatty acids and phospholipids have mild blood lipid-lowering effects, and a small number of patients have mild adverse reactions such as dry mouth and nausea; 5. Pantethine can significantly improve lipid metabolism and have a certain lipid-lowering effect, but it can Cause diarrhea and loss of appetite; 6. Sodium alginate has the effect of reducing blood viscosity, dilating blood vessels, and lowering blood lipids. Adverse reactions include upper abdominal discomfort, dizziness, and palpitations; 7. Hormones, the main function is to lower cholesterol, but more pronounced side effects
[0005] Judging from the current situation, there is no lipid-lowering product that meets the physiological requirements. The mechanism of action of traditional Chinese medicine for lipid-lowering is mainly to achieve the purpose of prevention and treatment by reducing the content of cholesterol or triglyceride in the body, with few side effects and high safety. , is the advantage of natural plants

Method used

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  • Complex preparation for regulating lipid and preventing and curing heart cerebrovascular diseases and preparation method thereof

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preparation example Construction

[0059] In the preparation method of the present invention, the turmeric extract, kudzu root extract and salvia miltiorrhiza extract are obtained by extracting with ethanol as an extractant, concentrating and drying.

[0060] The invention also provides an application of the traditional Chinese medicine composition in regulating blood pressure and preventing and treating cardiovascular and cerebrovascular diseases.

[0061] At present, the main clinical lipid detection indicators are: TC (total cholesterol), TG (triglyceride), HDL-C (high-density lipoprotein-cholesterol), LDL-C (low-density lipoprotein-cholesterol). 50 outpatients or inpatients from the Veteran Cadre Medical Department of Xiangya Hospital, Central South University, excluding family history of hypertension, diabetes and hyperlipidemia, aged 50.5±10.2 years old, did not use any other drugs during taking this product. Medication method: The patient takes the capsule of this product twice a day, 1 capsule each time...

Embodiment 1

[0066] Embodiment 1: Oral preparations and preparation methods for regulating blood lipids and preventing and treating cardiovascular and cerebrovascular diseases of traditional Chinese medicine prescriptions

[0067] 500 parts of turmeric; 100 parts of kudzu root; 100 parts of salvia

[0068] Preparation method: Take the above medicinal materials in the prescription amount, heat and reflux three times with 70% ethanol, the first time is 3 hours, the second time and the third time are 1.5 hours each, filter, combine the filtrates, recover ethanol, concentrate under reduced pressure to a relative density of 1.35 (55°C) thick paste. The thick paste is taken, dried, pulverized, an appropriate amount of dextrin is added, and an appropriate amount of 95% ethanol is used for granulation to make granules, hard capsules, tablets and the like.

Embodiment 2

[0069] Embodiment 2: Oral preparations and preparation methods for regulating blood lipids and preventing and treating cardiovascular and cerebrovascular diseases of traditional Chinese medicine prescriptions

[0070] 450 parts of turmeric; 150 parts of kudzu root; 100 parts of salvia

[0071] Preparation method: Take the above medicinal materials in the prescription amount, heat and reflux three times with 80% ethanol, the first time for 2 hours, the second time and the third time for 1 hour each, filter, combine the filtrates, recover ethanol, concentrate under reduced pressure to a relative density of 1.40 (55°C) thick paste. Take the thick paste, dry, pulverize, add appropriate amount of auxiliary materials microcrystalline cellulose and magnesium stearate, make soft material with PVP solution, and make granules, tablets or hard capsules according to the general method.

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Abstract

The invention provides a Chinese medicinal composition, which is characterized by comprising turmeric or turmeric extract, kudzu-vine root or kudzu-vine root extract, and salvia miltiorrhiza bunge or salvia miltiorrhiza bunge extract. The invention also provides a preparation method and use of the Chinese medicinal composition and a preparation having the Chinese medicinal composition or extract. The composition comprises 30 to 600 weight portions of turmeric, 10 to 400 weight portions of kudzu-vine root and 10 to 400 weight portions of salvia miltiorrhiza bunge. Or the composition comprises 30 to 600 weight portions of turmeric extract, 10 to 300 portions of kudzu-vine root extract and 10 to 300 portions of salvia miltiorrhiza bunge extract. The Chinese medicinal composition of the invention and the preparation having the Chinese medicinal composition or extract can be used for regulating lipid and preventing heart cerebrovascular diseases and the like.

Description

technical field [0001] The invention relates to a health care or medicinal compound preparation capable of regulating blood fat and preventing and treating cardiovascular and cerebrovascular diseases and a preparation method thereof. Background technique [0002] Modern clinical medical research believes that hyperlipidemia is the main cause of cerebral thrombosis, cerebral infarction, stroke, angina pectoris, myocardial infarction, coronary heart disease, sudden death and other diseases. Excessive intake of cholesterol in food causes hyperlipidemia, which can lead to several types of arteriosclerosis. Among them, aortic atherosclerosis can lead to aortic aneurysm; coronary atherosclerosis can lead to coronary heart disease, angina pectoris, myocardial infarction, and sudden death; cerebral atherosclerosis can lead to cerebral thrombosis, cerebral hemorrhage, brain atrophy, and dementia; Atherosclerosis can lead to refractory hypertension; atherosclerosis of the extremities...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61P3/06A61P9/00
Inventor 谭高辉张锦锋
Owner 湖南福湘生物技术有限公司
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