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Molecular sieve antibacterial coating with pure titanium or titanium alloy surface and preparation method thereof

A technology of antibacterial coating and molecular sieve, which is used in coating, medical science, prosthesis, etc. to prevent aseptic loosening, tight bonding, and stable coating.

Inactive Publication Date: 2010-08-04
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] At present, there is no report on the direct growth of molecular sieve coating and loading antibacterial ions on the surface of pure titanium or titanium alloy.

Method used

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  • Molecular sieve antibacterial coating with pure titanium or titanium alloy surface and preparation method thereof
  • Molecular sieve antibacterial coating with pure titanium or titanium alloy surface and preparation method thereof
  • Molecular sieve antibacterial coating with pure titanium or titanium alloy surface and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] With NaA molecular sieve as the surface coating, the silver ion content accounts for about 41% of the molecular sieve coating mass:

[0056] The size of the titanium sheet used is 8mm in diameter and 1mm in thickness.

[0057] Surface pretreatment of titanium sheets: Put the titanium sheets in deionized water containing 2% (v / v) white cat household detergent, soak at 80°C for 1h, then ultrasonically clean with deionized water, dry, Then irradiated with ultraviolet light for 18h;

[0058] Dissolve sodium metaaluminate in sodium hydroxide solution and stir until clear liquid to make aluminum source solution; dissolve sodium silicate nonahydrate in water and stir until clear to make silicon source solution, then slowly add aluminum source solution to silicon source solution , stirred for 30min, and the ratio was 43Na 2 O: 1Al 2 o 3 : 4.4SiO2 2 :840H 2 The sol of O was then left to stand for 1 hour to obtain the NaA molecular sieve synthesis solution; then the titaniu...

Embodiment 2

[0060] With NaA molecular sieve as the surface coating, the silver ion content accounts for 18% of the mass of the molecular sieve coating:

[0061] The surface pretreatment of the titanium sheet is the same as in Example 1.

[0062] Dissolve sodium metaaluminate in sodium hydroxide solution and stir until the clear liquid is made into aluminum source, dissolve sodium silicate nonahydrate in water and stir until clarified to make silicon source, slowly add aluminum source into silicon source, stir for 30min, then Stand for 1h to make a ratio of 45Na 2 O: 1Al 2 o 3 : 4.4SiO2 2 :900H 2 O sol to obtain NaA molecular sieve synthetic liquid. Suspend the cleaned titanium sheet vertically in the synthesis liquid, and put it in an oven at 80°C for 4 hours to react. Then take it out and let it cool naturally. The prepared molecular sieve membrane composite titanium sheet is cleaned with ultrapure water to avoid affecting ion exchange, and the molecular sieve composite titanium s...

Embodiment 3

[0064] With NaA molecular sieve as the surface coating, the silver ion content accounts for 9% of the mass of the molecular sieve coating:

[0065] The surface pretreatment of the titanium sheet is the same as in Example 1. The preparation process of the molecular sieve coating is the same as in Example 1.

[0066] Prepare silver nitrate aqueous solution (pH about 7) with a concentration of 0.001mol / L, measure 6.51mL and pour it into a centrifuge tube, put 5 molecular sieve composite titanium sheets, and perform ion exchange on a biological shaker at 180r / min at 50°C 20min, the exchange process must be protected from light. Take out the titanium sheet, and repeatedly wash it with ultrapure water ultrasonically until no white precipitate is formed in the cleaned solution with dilute HCl, and dry it with compressed air. That is, the molecular sieve antibacterial ion composite coating is obtained on the titanium sheet. Electron spectroscopy (EDS) test results show that the sil...

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Abstract

The invention relates to a surface antibacterial coating and a preparation method thereof, in particular to a molecular sieve antibacterial coating capable of being applied to surfaces of pure titanium or titanium alloy inner fixed plates, outer fixed plates, artificial joint prosthesis for clinical practices in an orthopedics department and a preparation method thereof. The preparation method of the coating comprises the following steps of: firstly growing a molecular sieve film on a pure titanium or titanium alloy surface, and then loading a definite amount of inorganic antibacterial ions on a molecular sieve layer by using an ion exchange technology to obtain a surface coating with antibacterial performance. The coating has favorable biocompatibility and biomechanical property, can release the inorganic antibacterial ions slowly, effectively restrict the bacteria growth at the periphery and on the surface of materials and can play a long-acting antibacterial role. The load capacity of the inorganic antibacterial ions can be regulated and controlled by simply changing ion exchange concentration, time, temperature and other conditions. The invention has the advantages of simple process, low cost, and the like, can be applied to pure titanium or titanium alloy apparatuses with any shapes and surface roughness degrees and is convenient for large-scale production.

Description

technical field [0001] The invention relates to a surface antibacterial coating and a preparation method thereof, in particular to a molecular sieve antibacterial coating on the surface of a pure titanium or titanium alloy internal fixation plate and an artificial joint prosthesis that can be used in clinical orthopedics and a preparation method thereof. technical background [0002] Pure titanium and titanium alloys have good biocompatibility, biomechanical properties and corrosion resistance, and have been widely used in the preparation of orthopedic implant materials. However, any non-biological implants, including pure titanium and titanium alloys, often carry the risk of postoperative infection. Postoperative infections caused by implanted materials generally cannot be cured by conventional systemic antibiotic therapy, because the biofilm formed by bacterial growth on the surface of the material can tolerate higher concentrations of antibiotics, and systemic administrat...

Claims

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Application Information

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IPC IPC(8): A61L27/30A61L27/06A61L31/08A61L31/02
Inventor 王金成王卓鹏郭嵩张净宇宋旸李激扬于吉红
Owner JILIN UNIV
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