Method for preparing intra-operative hemostatic material by cross emulsification of plant starch

A technology of plant starch and hemostatic material, applied in medical science, absorbent pads, bandages, etc., can solve the problems of unsatisfactory hemostatic effect, unsatisfactory active bleeding effect, rebleeding, etc. The effect of changing physical and chemical properties and promoting tissue healing

Active Publication Date: 2011-08-03
杜宝堂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the preparation process, epichlorohydrin was used as a cross-linking agent, which is a colorless oily liquid, toxic and narcotic, and potentially harmful to the human body; from the perspective of hemostatic effect, the water absorption rate is low and the water absorption speed is low. slow, and the hemostatic effect is not ideal, especially for active bleeding; the gel formed after absorbing water has poor viscosity and cannot effectively block damaged tissues and blood vessels. In active bleeding, hemostatic powder is difficult Attached to the bleeding site, it is easy to be washed away by the blood flow. If the auxiliary material is pressed on the hemostatic powder, the auxiliary material is easily adhered by the blood clot, and it is easy to cause re-bleeding when the auxiliary material is uncovered. Therefore, the effect on active bleeding is not ideal. and expensive
[0008] CN1947800A discloses a hemostatic microparticle and its preparation method. The hemostatic microparticle is made of potato starch,

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0035] Example 1

[0036] A method for preparing intraoperative hemostatic material by cross-emulsification of plant starch, comprising the following steps:

[0037] (1) Gelatinization: Dissolve raw potato starch in distilled water to prepare a wet starch solution with a weight percentage of 12%, then add it into the extrusion machine, and the starch is rubbed and extruded by the screw shaft to generate heat and then gelatinize , at 120 ℃ through high-pressure extrusion through the small hole of 3mm diameter on the extruder, after entering the atmosphere, the material expands and dries, and then is crushed and sieved to obtain gelatinized starch;

[0038] (2) Enzymatic hydrolysis: the gelatinized starch that has undergone the gelatinization pretreatment described in step (1) is prepared into an emulsion with a weight percentage of 25%, and then an enzyme solution prepared with a buffer is added thereto, Among them, the mass ratio of enzyme to starch was 0.05:1, the temperatur...

Example Embodiment

[0044] Example 2

[0045] A method for preparing intraoperative hemostatic material by cross-emulsification of plant starch, comprising the following steps:

[0046] (1) Gelatinization: Dissolve the raw sweet potato starch in distilled water to prepare a wet starch solution with a weight percentage of 20%, then add it into the extruder, and the starch is rubbed and extruded by the screw shaft to generate heat and then gelatinize , at 160 ℃ through high-pressure extrusion through the small hole of 8mm diameter on the extrusion extruder, after entering the atmosphere, the material expands and dries, and then is crushed and screened to obtain gelatinized starch;

[0047] (2) Enzymatic hydrolysis: the gelatinized starch that has undergone the gelatinization pretreatment described in step (1) is prepared into an emulsion with a weight percentage of 40%, and then an enzyme solution prepared with a buffer is added thereto, Among them, the mass ratio of enzyme to starch was 0.1:1, t...

Example Embodiment

[0053] Example 3

[0054] A method for preparing intraoperative hemostatic material by cross-emulsification of plant starch, comprising the following steps:

[0055] (1) Gelatinization: Dissolve raw tapioca starch in distilled water to prepare a wet starch solution with a weight percentage of 16%, then add it into the extrusion machine, and the starch is rubbed and extruded by the screw shaft to generate heat and then gelatinize , extruded at 140°C through a small hole with a diameter of 7 mm on the extruder, and the material expanded and dried after entering the atmosphere, and then the gelatinized starch was obtained by crushing and screening;

[0056] (2) Enzymatic hydrolysis: the gelatinized starch that has undergone the gelatinization pretreatment described in step (1) is prepared into an emulsion with a weight percentage of 30%, and then an enzyme solution prepared with a buffer is added thereto, Among them, the mass ratio of enzyme to starch was 0.06:1, the temperatu...

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Abstract

The invention discloses a method for preparing an intra-operative hemostatic material by cross emulsification of plant starch. The method comprises the following steps of: taking plant starch as a raw material; gelatinizing; carrying out enzymolysis; emulsifying and cross-linking; carrying out solvent extraction; washing; spray-drying; sieving; sterilizing; and packaging to obtain the hemostatic material. The hemostatic material prepared by adopting the method disclosed by the invention has excellent biological barrier properties and tissue compatibility, can directly act on a hemorrhagic wound surface, and is especially convenient for organs and tissues with complex shapes. The selected material is plant starch which has the advantages of no toxicity, no irritation, rich sources, low price, simple and feasible production processes, high water absorption speed, short hemostatic time, good using effect and wide clinical application prospect.

Description

technical field [0001] The invention relates to a method for preparing a microporous polysaccharide hemostatic material, in particular to a method for preparing a microporous polysaccharide hemostatic material through cross-emulsification using plant starch, and belongs to the technical field of hemostatic materials. Background technique [0002] Both surgical operations and trauma will form blood wounds, and a large amount of blood will be lost during the period. Good hemostasis technology is the key to ensure the success of the operation and the healing of the trauma. According to statistics, more than 10% of the wounded who died in the first aid of wounds in battlefields and peacetimes died due to excessive blood loss. The use of biocompatible absorbable hemostatic materials to act on bloody wounds is a common method of hemostasis at present, and there is an urgent need in medical aspects such as surgical hemostasis, trauma, and first aid hemostasis. To provide a safe and...

Claims

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Application Information

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IPC IPC(8): A61L15/28C08J3/24
Inventor 杜宝堂
Owner 杜宝堂
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