Graphene oxide modified by polyethylene glycol, and application of graphene oxide

A polyethylene glycol and graphene technology, applied in biochemical equipment and methods, enzymes, enzyme stabilization, etc., can solve problems such as failure to meet trypsin, trypsin stabilizer not found, etc., and achieve enhanced activity and stability. , improve the activity, the effect of simple synthesis
CN102432865AInactive Publication Date: 2012-05-02SUZHOU UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SUZHOU UNIV
Publication Date
2012-05-02
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to graphene oxide modified by polyethylene glycol. The graphene oxide can be used as trypsin activator. The graphene oxide modified by the polyethylene glycol comprises graphene oxide and polyethylene glycol; one end of the polyethylene glycol is an amino group, and other end of the polyethylene glycol is an imino group, and nitrogen atoms of the imino group and carbon atomsin carbonyl of the graphene oxide are connected with each other to form an amido bond; the height of the graphene oxide is 1 to 2nm, and the size of the graphene oxide is 10 to 30nm; the polyethyleneglycol is a liner-chain polyethylene glycol of which the molecular weight is 1,800 to 2,200; and the graphene oxide comprises 25 to 35 weight percent of the polyethylene glycol. The graphene oxide modified by the polyethylene glycol is easy to synthesize, and can specifically improve the activity and the thermal stability of trypsin; and the activity and stability of the trypsin are improved to meet biomedical demand of the trypsin.
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Description

technical field

[0001] The invention relates to a polyethylene glycol-modified graphene oxide that can be used as a trypsin activator. Background technique

[0002] Trypsin is a kind of serine protease, which is an important digestive enzyme in higher animals and human body. Trypsin is synthesized in the form of zymogen in the pancreas, secreted as a component of pancreatic juice, and then decomposed by enterokinase or trypsin to become biologically active trypsin. It is an endopeptidase that selectively hydrolyzes peptide chains formed by carboxyl groups of lysine or arginine in proteins (polypeptide chains).

[0003] In the body, trypsin not only acts as a digestive enzyme, but also acts on the precursors of other enzymes (such as chymotrypsinogen, carboxypeptidase, phospholipase, etc.) and activates them. Clinically, trypsin is often used to treat local edema, hematoma and abscess caused by empyema, hemothorax, ulcer, wound inflammation, traumatic injury, fistula, etc. ...

Claims

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