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Compound enrofloxacin pellets and preparation method thereof

A technology of enrofloxacin pellets and compound enrofloxacin, which can be applied to pharmaceutical formulations, medical preparations containing active ingredients, organic active ingredients, etc., and can solve the problems of increasing the number of medication, causing stress, poor palatability, etc. problems, to achieve the effect of reducing the dosage of medication, easy to achieve, and convenient to use

Inactive Publication Date: 2012-07-04
GUANGDONG WENS DAHUANONG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Clinically, enrofloxacin and amoxicillin are commonly used alone. In order to achieve the therapeutic effect, it is necessary to increase the dose or prolong the use time of the single drug, so that drug resistance and drug residues are likely to occur, and the single drug is time-consuming and laborious. If the injection is more labor-intensive and stressful
In addition, enrofloxacin has a bitter taste and poor palatability, which affects animal feed intake, and the rapid excretion of amoxicillin needs to increase the number of medications

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A compound enrofloxacin pellet, comprising a coating and a drug-loaded core, the drug-loaded core is a microparticle with a size not greater than 30 mesh, wherein the drug-loaded core contains the following components by weight percentage:

[0039] Amoxicillin 20%;

[0040] Enrofloxacin 10%;

[0041] Starch 37%;

[0042] Microcrystalline Cellulose 20%;

[0043] Sodium carboxymethyl starch 8%;

[0044] Granulation binder 5%;

[0045] Wherein, the granulation binder is polyvinylpyrrolidone.

[0046] The weight of the coating is 5% of the total weight of the compound enrofloxacin pellets, wherein the coating comprises the following components in percentage by weight:

[0047] Hydroxypropyl Methyl Cellulose 7%;

[0048] Talc 4%.

[0049] The preparation method of described compound enrofloxacin pellets comprises the following specific steps:

[0050] Step 1) Weigh 5g of polyvinylpyrrolidone and dissolve in ethanol or hot water to obtain the granulation binder;

[0...

Embodiment 2

[0055] A compound enrofloxacin pellet, comprising a coating and a drug-loaded core, the drug-loaded core is a microparticle with a size not greater than 30 mesh, wherein the drug-loaded core contains the following components by weight percentage:

[0056] Amoxicillin 30%;

[0057] Enrofloxacin 15%;

[0058] Starch 30%;

[0059] Microcrystalline Cellulose 15%;

[0060] Sodium carboxymethyl starch 5%;

[0061] Granulation binder 5%;

[0062] Wherein, the granulation binder is sodium carboxymethylcellulose.

[0063] The weight of the coating is 5% of the total weight of the compound enrofloxacin pellets, wherein the coating comprises the following components in percentage by weight:

[0064] Hydroxypropyl Methyl Cellulose 10%;

[0065] Talc 2%.

[0066] The preparation method of described compound enrofloxacin pellets comprises the following specific steps:

[0067] Step 1) Weigh 5 g of sodium carboxymethylcellulose and dissolve in hot water to obtain the granulation binder...

Embodiment 3

[0072] A compound enrofloxacin pellet, comprising a coating and a drug-loaded core, the drug-loaded core is a microparticle with a size not greater than 30 mesh, wherein the drug-loaded core contains the following components by weight percentage:

[0073] Amoxicillin 10%;

[0074] Enrofloxacin 5%;

[0075] Starch 43%;

[0076] Microcrystalline Cellulose 25%;

[0077] Sodium Carboxymethyl Starch 10%;

[0078] Granulation binder 7%;

[0079] Wherein, the granulation binder is starch.

[0080] The weight of the coating is 2% of the total weight of the compound enrofloxacin pellets, wherein the coating comprises the following components in percentage by weight:

[0081] Hydroxypropyl methylcellulose 2%;

[0082] Talc 6%.

[0083] The preparation method of described compound enrofloxacin pellets comprises the following specific steps:

[0084] Step 1) Dissolve in hot water after weighing 7g of starch to obtain the granulation binder;

[0085] Step 2) Weigh the following co...

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Abstract

The invention relates to compound enrofloxacin pellets and a preparation method of the compound enrofloxacin pellets, wherein the enrofloxacin pellets comprise coatings and medicine-carrying pill cores; the coatings wrap the medicine-carrying pill cores; the medicine-carrying pill cores are prepared by the following steps that: amoxicillin and enrofloxacin are mixed with starch, microcrystalline cellulose, carboxymethyl starch and the like uniformly; an appropriate amount of pelleting adhesive is added in the mixture to prepare the soft material, the soft material is added into an extrusion pelleter to be extruded out, the extruded material is placed in a shot blasting machine to prepare the medicine-carrying pill cores. Then, the pill cores are placed into a fluidized bed to be dried andthen sieved; finally the sieved pill cores are placed into the fluidized bed, coating liquid is injected for coating, fluidized drying is then carried out after the coating, and then the finished product is obtained. According to the invention, both the amoxicillin and enrofloxacin are used, so that double effects are achieved, the medicine administration frequency and dose are reduced, and the pellets are easy to take only by stirring, and feed intake of animals is not influenced. In addition, the preparation method of the compound enrofloxacin pellets has simple process steps and low energyconsumption, is safe to produce and easy to implement, and the prepared pellets have uniform granularity.

Description

technical field [0001] The invention belongs to the field of veterinary drug preparations, in particular to compound enrofloxacin pellets and a preparation method thereof. Background technique [0002] Enrofloxacin is the first fluoroquinolone (Fluroquinolones) drug specially used for livestock and poultry. It has a broad-spectrum bactericidal effect and is effective against bacteria in the stationary phase and growth phase. It has strong bactericidal activity and wide distribution in the body. It is compatible with other antibacterial drugs. No cross-resistance and other characteristics, it has good antibacterial effect on a variety of Gram-negative bacilli and cocci, including Pseudomonas aeruginosa, Klebsiella, Escherichia coli, Enterobacter, Shigella, and Salmonella , Aeromonas, Haemophilus, Vibrio, Proteus, etc., against Brucella, Pasteurella, Erysipelothrix, Staphylococcus, etc., and also effective against Mycoplasma and Chlamydia ; It has good effects on synergistic ...

Claims

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Application Information

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IPC IPC(8): A61K31/496A61K9/16A61P31/04A61K31/43
Inventor 刘小艳方炳虎陈瑞爱
Owner GUANGDONG WENS DAHUANONG BIOTECH
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