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Preparation technology of porous calcium gluconate tantalite/nono-funicular hydroxylapatite bioactive coating

A technology of hydroxyapatite and nanofibers, which is applied in the coating process of metal materials, coating, superimposed layer plating, etc., can solve the problems of far apart crystal forms and low ability of new bone formation, and achieve the promotion of Adhesion and growth, simple composition, stable process effect

Inactive Publication Date: 2014-08-06
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing technologies such as plasma spraying, laser cladding, ion beam enhanced deposition, magnetron sputtering, and micro-arc oxidation can obtain hydroxyapatite on the surface of dense metal substrates, but the obtained hydroxyapatite is not in the form of nanofibers. Very far from the crystalline form of the inorganic mineral apatite in bone, resulting in a lower ability to promote new bone formation

Method used

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  • Preparation technology of porous calcium gluconate tantalite/nono-funicular hydroxylapatite bioactive coating
  • Preparation technology of porous calcium gluconate tantalite/nono-funicular hydroxylapatite bioactive coating
  • Preparation technology of porous calcium gluconate tantalite/nono-funicular hydroxylapatite bioactive coating

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Embodiment 1

[0022] Will contain 0.2M (CH 3 COO) 2 Ca with 0.02M β-C 3 h 7 Na 2 o 6 An aqueous solution of P serves as the electrolyte. Using metal tantalum sheet as anode and stainless steel as cathode, using DC pulse power supply, under the conditions of positive voltage 470 volts, negative voltage 100 volts, frequency 100 Hz, and duty cycle 26%, the tantalum sheet was subjected to micro-arc oxidation treatment for 5 minutes. , the calcium tantalate-based multiphase layer containing calcium and phosphorus was obtained, and the SEM photos of the surface and cross-section microscopic morphology were respectively referred to figure 1 (a) and (b). Then the calcium tantalate-based multiphase layer / tantalum sheet sample obtained after micro-arc oxidation treatment was suspended in a hydrothermal reaction kettle with a concentration of 0.01M β-C 3 h 7 Na 2 o 6 Above the P aqueous solution, the filling degree of the solution is 15%, and it is hydrothermally treated at 140°C for 3 hours...

Embodiment 2

[0024] Will contain 0.2M (CH 3 COO) 2 Ca with 0.02M β-C 3 h 7 Na 2 o 6 An aqueous solution of P serves as the electrolyte. Using metal tantalum sheet as anode and stainless steel as cathode, using DC pulse power supply, under the conditions of positive voltage 470 volts, negative voltage 100 volts, frequency 100 Hz, and duty cycle 26%, the tantalum sheet was subjected to micro-arc oxidation treatment for 5 minutes. , to obtain a calcium tantalate-based multiphase layer containing calcium and phosphorus. Then the calcium tantalate-based multiphase layer / tantalum sheet sample obtained after micro-arc oxidation treatment was suspended in a hydrothermal reaction kettle with a concentration of 0.01M β-C 3 h 7 Na 2 o 6 Above the P aqueous solution, the filling degree of the solution is 15%, and it is hydrothermally treated at 140°C for 24 hours, and the fibers that are closely arranged and parallel to the calcium tantalate-based multiphase layer can be obtained, and the fib...

Embodiment 3

[0026] Will contain 0.2M (CH 3 COO) 2 Ca with 0.02M β-C 3 h 7 Na 2 o 6 An aqueous solution of P serves as the electrolyte. Using metal tantalum sheet as anode and stainless steel as cathode, using DC pulse power supply, under the conditions of positive voltage 470 volts, negative voltage 100 volts, frequency 100 Hz, and duty cycle 26%, the tantalum sheet was subjected to micro-arc oxidation treatment for 5 minutes. , to obtain a calcium tantalate-based multiphase layer containing calcium and phosphorus, and then soak the calcium tantalate-based multiphase layer / tantalum sheet sample obtained after micro-arc oxidation treatment into a hydrothermal reaction kettle with a concentration of 0.01M β-C 3 h 7 Na 2 o 6 In the P aqueous solution, the filling degree of the solution is 15%, and it is hydrothermally treated at 140°C for 3 hours, and the fibers that are closely arranged and parallel to the calcium tantalate-based multiphase layer can be obtained, and the fiber diame...

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Abstract

The invention discloses a preparation technology of porous calcium gluconate tantalite / nono-funicular hydroxylapatite bioactive coating. The preparation technology comprises the following step of firstly preparing calcium and phosphorus-containing gluconate tantalite-based complex phase layer on the surface of tantalite by a micro arc oxidation technology, i.e. taking calcium and phosphorus-containing water solution as electrolyte, carrying out the micro arc oxidation treatment on the tantalum under high voltage by using a pulse power source, and carrying out the hydro-thermal treatment on the calcium and phosphorus-containing gluconate tantalite-based complex phase layer under a special hydro-thermal environment condition. The obtained coating with a double-layer structure has the following structure and performance characteristics: an inner layer (which is adjacent to a base body) is a gluconate tantalite-based complex phase layer which consists of gluconate tantalite, and a trace amount of antalum pentoxide and tantalum monoxide and is of a microporous structure in shape; and a surface layer is nono-funicular hydroxylapatite, which is inclined to or in parallel with the gluconate tantalite-based complex phase layer. No incontinuous interface exists between the coating with the double-layer structure and the base body, so that the coating is high in combining strength, and the osteolith can be quickly formed in the pseudo body fluid environment in an inducing way, so that the coating is good in biological activity.

Description

technical field [0001] The invention belongs to the technical field of bioactivation modification of medical metal surfaces, and relates to a preparation technology of a tantalum-based medical implant surface bioactive coating, in particular to a porous calcium tantalate and nanofibrous hydroxyapatite double-layer structure coating. Micro-arc oxidation and hydrothermal preparation technology of layers to construct human hard tissue repair and replacement devices with good mechanical and biological properties. Background technique [0002] Tantalum has good biocompatibility and has important application potential in artificial bone, hip or knee joint head prosthesis, orthopedic surgery, etc. However, tantalum is a biologically inert material, which cannot be chemically combined with bone formation in the early stage of implantation, nor has the ability to promote new bone formation, and takes a long time to heal, so it needs to be modified by surface bioactivation. Hydroxyap...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C23C28/04
Inventor 憨勇王翠翠
Owner XI AN JIAOTONG UNIV
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