Method for preparing medical porous metal implant material

A technology for implant materials and porous metal, which is applied in the field of preparation of medical metal implant materials, can solve the problems affecting the processing of porous tantalum materials, mechanical properties such as ductility, compressive strength, and insufficient bending strength, so as to improve biocompatibility And biological safety, good uniformity of finished product pore size, good effect of biocompatibility

Active Publication Date: 2012-11-28
CHONGQING RUNZE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, porous tantalum, which is used as a medical implant material for compact bone tissue such as dental bone, has obvious deficiencies in mechanical properties such as ductility, compressive strength, and bending strength, and will affect subsequent research on porous tantalum. Processing of the material itself, such as cutting of molded parts, etc.

Method used

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  • Method for preparing medical porous metal implant material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1: Take paraffin wax, tantalum powder and ethyl cellulose with an average particle size less than 43 microns and an oxygen content of less than 0.1% and mix them uniformly to form a mixed powder, wherein paraffin wax accounts for 8%, ethyl cellulose accounts for 27%, tantalum powder accounts for 65%, all in volume percentage. Granulation: The mixed powder is granulated into round particles with a particle diameter of 10-13 μm at a working temperature of 510-520° C. and a working pressure of 12-13 MPa. Injection molding: the temperature for injecting the round particles into the mold is 465-490° C. and the pressure is 83-85 MPa. Demolding time: 6~7S. Degreasing treatment: vacuum degree 10 -4 Pa, rise from room temperature to 400°C at a rate of 1-3°C / min, hold for 60-120 minutes, rise from 400°C to 600-800°C at a rate of 1.5-2.5°C / min, and hold for 180-240 minutes. Vacuum sintering: sintering in a vacuum furnace, the sintering temperature is 2000°C, the heat...

Embodiment 2

[0024] Embodiment 2: Weigh polyvinyl alcohol, tantalum powder with an average particle size less than 43 microns and an oxygen content of less than 0.1%, and sodium bicarbonate and mix them uniformly to form a mixed powder, wherein polyvinyl alcohol accounts for 6%, sodium bicarbonate accounts for 29%, tantalum Powder accounted for 65%, all in volume percentage. Granulation: The mixed powder was granulated into round particles with a particle diameter of 20 μm at a working temperature of 450° C. and a working pressure of 15 MPa. Injection molding: the temperature of injecting the round particles into the mold is 540° C. and the pressure is 90 MPa. Demolding time: 9S. Degreasing treatment: vacuum degree 10 -4 Pa, raise the temperature from room temperature to 400°C at a heating rate of 1°C / min, and hold for 60 minutes; then raise the temperature from 400°C to 800°C at a heating rate of 2.5°C / min, and hold for 180 minutes. Vacuum sintering: sintering in a vacuum furnace, the ...

Embodiment 3

[0026] Embodiment 3: take by weighing zinc stearate, average particle diameter less than 43 micron oxygen content less than 0.1% tantalum powder and methyl cellulose and mix uniformly into mixed powder, wherein zinc stearate accounts for 10%, methyl cellulose accounts for 10%. 23%, tantalum powder accounted for 67%, both by volume percentage. Granulation: The mixed powder was granulated into circular particles with a particle diameter of 10 μm at a working temperature of 650° C. and a working pressure of 12 MPa. Injection molding: the temperature of injecting the round particles into the mold is 380° C. and the pressure is 72 MPa. Demolding time: 6S. Degreasing treatment: vacuum degree 10 -4 Pa, from room temperature to 400°C at a heating rate of 3°C / min and hold for 120 minutes; then at a heating rate of 1.5°C / min from 400°C to 750°C for 240 minutes. Vacuum sintering: sintering in a vacuum furnace, the sintering temperature is 2200°C, the heat preservation is 2.5 hours, an...

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Abstract

The invention discloses a method for preparing a medical porous metal implant material. The method comprises the following steps of: mixing tantalum powder, a pore forming agent and a forming agent to obtain mixed power, wherein the pore forming agent is one or more of sodium bicarbonate, urea, sodium chloride, methylcellulose and ethylcellulose, and the forming agent is one or more of polyvinyl alcohol, stearic acid, zinc stearate, paraffin wax and synthetic rubber; pelletizing; injecting into a mould and forming; demoulding; degreasing, namely gradually raising temperature to 400 to 800 DEG C at the speed of 0.5 to 3 DEG C/min, introducing argon to form protective atmosphere and preserving heat for 60 to 240 minutes; sintering; and performing thermal treatment, namely raising temperature to 800 to 900 DGE C at the speed of 10 to 20 DEG C/min under the vacuum degree of 10<-4> to 10<-3> Pa, preserving heat for 240 to 480 minutes, cooling to 400 DEG C at the speed of 2 to 5 DEG C/min, preserving heat for 120 to 300 minutes, and cooling to room temperature along with a furnace, and finally, the medical porous metal implant material for replacing dentale tissues can be obtained. Through tests, the prepared porous tantalum material is very suitable to be used as the medical implant material for replacing dentale tissues.

Description

technical field [0001] The invention relates to a preparation method of a medical metal implant material, in particular to a preparation method of a medical porous metal implant material. Background technique [0002] Porous medical metal implant materials have important and special uses in the treatment of bone tissue trauma, femoral tissue necrosis, and replacement of dense bone tissue such as dental bone. The common materials of this type include porous metal stainless steel and porous metal titanium. As a porous implant material used in the treatment of bone tissue trauma and femoral tissue necrosis, its porosity should reach 30-80%, and the pores should be all connected and evenly distributed, or it should be consistent with the growth of human bone tissue as needed. , and reduce the weight of the material itself, so that it is suitable for human implantation. [0003] As for the refractory metal tantalum, due to its excellent biocompatibility, its porous material is e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C22C1/08C22C27/02A61L27/04A61L27/56
CPCA61L2430/02B22F2998/10A61L2430/12A61L27/047A61L2400/08A61L27/04A61L27/56B22F3/1121C22C1/08C22C27/02B22F1/10B22F3/225B22F3/10
Inventor 叶雷
Owner CHONGQING RUNZE PHARM CO LTD
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